Tocopherols Inhibits the Onset of Liver Cancer in Vitro

By Kyle J. Norton


The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage of injury.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells' DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to the overexpression of the overweight and obese population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

There is a number of risk factors other than those mentioned above associated with the onset of liver cancer such as male, ethnicity, hepatitis viral carriers.

However, most people with some of the above risk factors have never developed liver cancer.

According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.

In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.

Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31%, and 43% of people with liver cancer are diagnosed at stages 0 and 1.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the prevention and treatment of cancers, researchers examined the effect of poly(lactide-co-glycolide)/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles to accomplish the simultaneous delivery of an optimized ratio of doxorubicin (DOX) and elacridar (ELC) to target both LCSCs and liver cancer cells.

According to the analysis, in vitro
* DOX/ELC molar ratio of 1:1 works synergistically to exhibit significantly increased cytotoxic effects against both HepG2 and HepG2-TS
* DOX/ELC showed a stronger anti-cancer activity, compared with DOX-loaded nanoparticles (NDs) or ELC-loaded nanoparticles (NEs).

* Furthermore, the nanoparticles exhibited better tumor targeting, with NDE showing the strongest antitumor activity with lower systemic toxicity.

Based on the findings, researchers said, "These results suggested that NDE represented a promising combination therapy against liver cancer by targeting both liver cancer cells and CSCs".

Taken altogether, tocopherols may be considered a supplement for reducing the risk of liver cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles by Chen D1,2,3, Pan X4, Xie F5, Lu Y2, Zou H2, Yin C6, Zhang Y7, Gao J. (PubMed)

Beta-Sitosterol, the Potential Treatment of Atopic Dermatitis

By Kyle J. Norton

Skin, a large organ that forms the out layers of our body has serval layers of ectodermal tissue to protect the underlying muscles, bones, ligaments, and internal organs against foreign pathogenic invasion.

Dermatitis or eczema is a group of diseases characterized by the inflammation of the skin.

There is no single cause of eczema, anything that we face every day can trigger a dermatitis flare, including stress, irritants, climate change, and sweating. However, infection and allergens. are considered the most common causes of the disease.

Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.

Most cases of atopic dermatitis are found in children. However, adults may also get it too.

The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environmental conditions may involve in the development of the disease.

Epidemiological studies suggested that most patients with chronic atopic dermatitis also have asthma and hay fever, particularly allergies.

Atopic dermatitis has been found to associate with exposure to allergens such as pollen, pet dander, or peanuts, or by stress, dry skin, and infection.

Some atopic dermatitis may also be triggered by skin irritants such as some fabrics, soaps, and household cleaners.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of skin diseases, researchers examined the effect of β-sitosterol (BS) on atopic dermatitis (AD).

In NC/Nga mice induced AD-like skin lesions in NC/Nga by 2,4-dinitrofluorobenzene (DNFB), BS reduced the total clinical severity of AD.

The application of BS inhibited the Infiltration of inflammatory cells and the number of scratching, compared to the DNFB-treated group.

In other words, BS significantly reduced the levels of inflammation-related mRNA and protein and tumor necrosis factor-α from the stimulated splenocytes in the AD skin lesions.

Furthermore, BS significantly also reduced the levels of histamine, IgE, and interleukin-4 associated with skin inflammation n the serum of DNFB-treated NC/Nga mice

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of atopic dermatitis, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP by Han NR1, Kim HM, Jeong HJ. (PubMed)

Healthy Food Turmeric Inhibits the Brain Cell Damage Against the Onset of Memory Deficits

By Kyle J. Norton

Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.

Memory loss frequently is an early sign of memory deficit. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.

Some memory changes can be resolved on their own or cured by medical treatment if the underlining cause is found. However, loss or gradual loss of neurons capacity cannot be revered such as dementia.

According to statistics, in the US, approximately 5.7 million people are living with dementia. The most common form of dementia is Alzheimer's disease, affecting 5.5 million people of all ages.


The most common risk factor associated with memory deficit is increasing age, smoking the genetic preposition of APOE-e4, also linked to Alzheimer's disease, obesity, and medical conditions such as diabetes, high blood pressure and depression, and physical inactivity.

Out of many risk factors, aging may be one of the major culprits that cause memory deficit in large numbers of older adults, leading to irreversible memory impairment such as AD and PD.

Dr. Gary W Small, said, "Memory changes cause concern to many patients as they grow older.". However, there are some factors that can decrease the progression of the condition, including stress reduction, physical and mental activity, a healthy diet, and lifestyle choices.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound that processes anti-neuro-degeneration, researchers examined the effects of curcumin on the early stage amnesia of AD related to memory retrieval deficit.


Selected Male NMRI mice (20-25 g body weight) included in the study were treated with 50 or 100 mg/kg/po curcumin or its vehicle for 10 days. During the experiment, the animals were trained in passive avoidance apparatus ar days 10 and 30 min. before the retention test that performs after 24 hours of curcumin or its vehicle application, scopolamine (1 mg/kg/i.p.) or its vehicle was administrated.

According to the tested analysis, curcumin treatment at 50 and 100 mg/kg doses not only inhibited the activity of scopolamine in the induction of memory retrieval deficit but also restored Akt and GSK dephosphorylation associated with neuroprotection against scopolamine.


In other words, curcumin at the tested concentration effectively protect the Akt and GSK pathways which play are a critical role in enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis caused by scopolamine in the brain.

After taking others into account, Dr. Lv KJ, wrote in the final report, "pre-test scopolamine administration disrupts memory retrieval along with with with with the diminished Akt and GSK-3β phosphorylation in the hippocampus while curcumin administration prevented those changes."

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of memory retrieval deficit, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats by Yuliani S1, Mustofa2, Partadiredja G. (PubMed)
(2) Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3β by SoukhakLari R1, Moezi L2, Pirsalami F3, Ashjazadeh N4, Moosavi M. (PubMed)
(3) What we need to know about age related memory loss by Gary W Small, Parlow-Solomon professor on aging. (PMC)

Pungent Spice Onion May Process Anti Asthmatic Property

By Kyle J. Norton

Respiratory disease is a class of medical conditions that affect the breathing organ and tissues. The most common respiratory diseases are inflammatory lung disease, obstructive lung diseases, restrictive lung diseases, and respiratory tract infections.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

The medical condition affects people of all ages, and mostly starts during childhood.

In the US, approximately, 25 million people are living with asthma, including 7 million children.


The most common risk factors associated with the onset of asthma, according to epidemiological studies are
* Wheezing rhinovirus illnesses
Virus-induced wheezing episodes in infancy often precede the development of asthma.

*Airflow obstruction
Asthma and family history of allergic rhinitis are important risk factors associated with airflow. according to the Department of Pediatrics, Lerdsin General Hospitalobstruction.

* Gender
If you are a woman, you are at increased risk to develop asthma. Asthma, after childhood, is more severe in females than in males and is under-diagnosed and under-treated in female adolescents.

* Stress
Stress, whether at the individual (i.e. epigenetics, perceived stress), family (i.e. prenatal maternal stress, early-life exposure, or intimate partner violence), or community (i.e. neighborhood violence; neighborhood disadvantage) level, influence asthma and asthma morbidity.

* Genes
GSTP1, INSIG2, and IL4Ra may influence lifetime asthma susceptibility through gene-gene interactions in schoolchildren.

* Airway inflammation and hyperreactivity
People with airway hyperreactivity are at increased risk to develop asthma as a result of the immune system over-response to allergens.

5. Atopy and viral infection
Atopy – such as eczema, allergic rhinitis, allergic conjunctivitis, and viral infection are associated with a higher risk of asthma development.

* Family history
Family history of asthma in one or more first-degree relatives was consistently identified as a risk factor for asthma.

* Smoke during Pregnancy
Smoking and severe asthma exacerbations in pregnancy are risk factors for low birth weight babies.
During pregnancy, asthma exacerbations are more common and more severe in current smokers than never smokers. The risk of the effects of maternal asthma on the fetus may be greater among smokers.

* Low birth weight
In the 1988 national birth cohort, an estimated 4000 excess asthma cases were attributable to birth weight less than 2500 g.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of asthma researchers investigated the effect of Allium cepa L. extract (AcE) and its quercetin (Qt) on cytokine and on smooth muscle contraction associated with asthma in vitro and Vivo.

According to the tested analysis, * In vitro, AcE 10, 100 or 1000 μg/ml or Qt 35, 7.5, 15 μg/ml, showed a significant effect in inhibition of the production of pro-inflammatory cytokines.

* With the same concentrations, AcE also expressed the ability to relax tracheal smooth muscle from A/J mice.

* Furthermore, with the concentrations of 100, 1000 mg/kg or 30 mg/kg Qt in Blomia tropicalis (BT)-sensitized A/J mice treated, AcE also decreased the total number of cells of bronchoalveolar lavage (BAL), and eosinophil peroxidase (EPO) in lungs, the markers found in patients with asthma.

Based on the results, researchers wrote, "AcE and Qt have potential as antiasthmatic drugs, as they possess both immunomodulatory and bronchodilatory properties".

Taken altogether, onion may be considered a remedy for the prevention and treatment of asthma, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma by Oliveira TT1, Campos KM2, Cerqueira-Lima AT3, Cana Brasil Carneiro T4, da Silva Velozo E5, Ribeiro Melo IC6, Figueiredo EA7, de Jesus Oliveira E8, de Vasconcelos DF9, Pontes-de-Carvalho LC10, Alcântara-Neves NM11, Figueiredo CA. (PubMed)
(2) Onions, myths, beliefs, fashion and reality in asthma by Martínez-Gimeno A. (PubMed)
(3)
Asthma (Respiratory Disease) – The Risk factors by Kyle J. Norton

Phytochemical Tocopherols Prevent the Risk of Type 2 Diabetes Induced by Oxidative Stress

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

The most common forms of Diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutations and viruses.

* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body's metabolized glucose. In other words, most cases of type 2 diabetes are the result of insulin receptors clogged up by fat and cholesterol, leading to resisting the effects of the hormone insulin that regulates the movement of sugar into your cells.

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

Oxidative stress is a condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes.

type 2 

In some cases, oxidative stress can also be caused by the long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of diabetes, researchers examined the effect of α-tocopherol on bone marrow mesenchymal cells derived (BMMCs) from type II diabetes mellitus rats.

According to the experimental results of BMMCs either untreated or exposed to α-tocopherol at concentrations of 1.0, 10, and 100 μM, at the concentration of 100 μM, α-tocopherol showed no effect on cell proliferation, but the significantly increased H2O2 activity against the tested cells.

At 10 μM, α-tocopherol increased the gene expression of pro-inflammatory cytokines such as IL-1β and TNF-α.

Furthermore, the concentration of 100 μM α-tocopherol exerted a lower expression of free radical catalase compared to the other concentrations.

Based on the findings, researchers said, "At a low concentration, α-tocopherol exerted good antioxidant and anti-inflammatory effects on BMMCs" and

"Maintaining α-tocopherol at a low concentration might promote the recovery of BMMCs from oxidative stress".

Taken altogether, tocopherols may be considered a functional food for the prevention and treatment of type 2 diabetes induced by oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of α-tocopherol on bone marrow mesenchymal cells derived from type II diabetes mellitus rats by Noguchi M1, Yamawaki I1, Takahashi S1, Taguchi Y1, Umeda M. (PubMed)

Dandelion (Taraxacum officinale) in the Management and Treatment of Type 2 Diabetes

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

The most common forms of Diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin.

The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

As of today, there is no cure for type 1 diabetes. Treatment is focusing on managing blood sugar levels with insulin injection, diet, and lifestyle change.

* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body's metabolized glucose. In other words, most cases of type 2 diabetes are the result of insulin receptors clogged up by fat and cholesterol, leading to resisting the effects of the hormone insulin that regulates the movement of sugar into your cells.

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

* Latent autoimmune diabetes in adults (LADA), similar to type 1 diabetes, is a slow-progressing form of autoimmune diabetes. The disease is caused by the pancreas' inability to produce enough insulin, because of slowly die-off of insulin-producing cells in the pancreas.

LADA is also known as type 1.5 diabetes because the disease has characteristics of both type 1 (autoimmune in nature) and type 2 diabetes.

Therefore, LADA shares the same risk factors and symptoms similar to those types 1 and 2 diabetes.

Unlike type 2 diabetes, patients with LADA do not respond well to seems to lifestyle and medication as in type-2 diabetes in the long term. Medicine used for the treatment of type 2 diabetes does not halt or slow the progression of loss of pancreas beta cells.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of chronic low-grade inflammatory diseases, scientists examined the dandelion anti-type 2 diabetes (T2D) activity.

According to test differentiation, the root of dandelion contains inulin, including fructooligosaccharides (FOS), a complex carbohydrate that normalizes blood sugar levels.

Other compounds chlorogenic and chicoric acid found in dandelion not only prevent obesity and inflammation but also have a strong impact on insulin secretion and sensitivity.

Other active compounds isolated from dandelion such as sesquiterpene lactones, triterpenes/phytosterols (taraxasterol), phenols, flavonoids, and phenolic acids also have demonstrated a series of anti-diabetic effects, due to the pharmacological actions of components.

In hyperglycemia, a hallmark in T2D fructooligosaccharides (FOS) exerted a significant activity that affects glucose homeostasis in oxidative stress, leading to auto-oxidation and protein glycation and increasing the production of lipid peroxide which in turn decreases the anti-oxidative defense induce β-cell dysfunction.

Furthermore, dandelion also manifests its anti-diabetic properties, through the inhibited renal glucose reabsorption and potassium channel flow, reduced the activity of carbohydrate enzymes (α-amylase with β-galactosidase and α-glucosidase), and reduced dietary blood sugar (which stimulates hepatic glycolysis and glycogenesis).

Based on the findings, researchers said, "Dandelion has been considered a key anti-diabetic plant because of its anti-hyperglycemic, anti-oxidative, and anti-inflammatory properties [44]. This is due to the various bioactive components present in dandelion, including polyphenolics, sesquiterpenes, triterpenes, and phytosterols".

Taken altogether, dandelion may be considered a remedy for the management and treatment of type 2 diabetes, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes by Wirngo FE1, Lambert MN1, Jeppesen PB. (PubMed)

Antioxidant Omega3 Fatty Acids Are Effective Against Psoriasis, Studies Suggest

By Kyle J. Norton

Psoriasis is a skin condition characterized by the speed-up of the life cycle of skin cells, leading to cells building up rapidly on the surface of the skin.

Symptoms of psoriasis caused by the extra skin cells from scales and red patches can be itchy and painful.

Epidemiologically, psoriasis patches can range from a few spots or large areas. The most common form of psoriasis is plaque psoriasis, a condition that induces dry, raised, red skin lesions (plaques) covered with silvery scales.

The causes of psoriasis are not identified, however, researchers believed that genetic proposition exacerbated by certain factors such as weather, injury, illness, or stress are some of the most causative factors that induce the onset of the condition.

Certain risk factors such as family history, viral and bacterial infections, weakened immune systems, persistent stress, are associated with the risk of psoriasis.

Other risk factors associated with psoriasis may include skin injury that did not heal properly, people who are obese and side effects of long-term use of certain medicines such as oral steroids.

Some researchers suggested smoking that has a strong impact on the immune system may also be one of the major causes of psoriasis in smokers.

Conventionally, topical corticosteroids are the most commonly prescribed medication for the treatment of the condition, particularly in patients with mild to moderate psoriasis.


According to the joint study led by the University of Trieste, the increased incidence of a large number of diseases that share an inflammatory origin is probably due to the pro-inflammatory cytokine spillover from active psoriatic lesions, leading to a large inflammation on distant tissues(95).

Additionally, the Brigham and Women's Hospital, and Harvard Medical School, Boston joint study suggested, individuals with psoriasis have increased blood levels of uric acid. In the documented 2217 incident cases of gout during follow-up. Psoriasis was associated with an increased risk of subsequent gout with a multivariate HR of 1.71

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of skin diseases, researchers examined the efficacy and mechanism of action of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on psoriasis.


The Cochrane Central Register of Controlled Trials that searches the databases of the PubMed/MEDLINE and EMBASE all randomized controlled trials and prospective observational studies compared the 3 PUFAs effects versus control in adult patients with psoriasis.

Out of 12 articles identified in a total of 732 articles that were searched, some studies found that n-3 PUFAs were associated with improvements in the PASI score, erythema, scaling, itching, an area involved, and infiltration.

However, some studies did not find a reduction in scaling, erythema, area involved or thickness in the treatment group.

Based on the findings researchers said, "It is still inconclusive whether the use of n-3 PUFAs in patients with psoriasis is associated with improvements in the severity of psoriasis and other outcomes".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of psoriasis, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of omega-3 fatty acids on disease severity in patients with psoriasis: A systematic review by Upala S1,2, Yong WC1, Theparee T3, Sanguankeo A. (PubMed)
(2) Efficacy of ω-3 supplementation in patients with psoriasis: a meta-analysis of randomized controlled trials by Clark CCT1, Taghizadeh M2, Nahavandi M2, Jafarnejad S. (PubMed)
(3) Increased airway inflammation in patients with psoriasis by Damiani G1, Radaeli A2, Olivini A2, Calvara-Pinton P3, Malerba M2. (PubMed)(4) Psoriasis, psoriatic arthritis and risk of gout in US men and women by Merola JF1, Wu S2, Han J3, Choi HK4, Qureshi AA5.(PubMed)

Chaste Tree Berry May be a Valuable Remedy For theTreatment of Cancers, Researchers Suggest

By Kyle J. Norton

Chaste tree berry is found to exhibit a significant anti-cancer activity, a recent study by renowned study advised.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Cancer is a class of diseases characterized by cells growing and multiplying disordered and uncontrollable ways in our body. In the late stage, the cancer cells may travel away from the originated site to infect other tissues and organs.

According to the Tianjin Institute for Biomedicinal Research, in the evaluated the apoptosis-inducing effect of chaste tree berry, using observation under a light microscope, flow cytometric analysis, and agarose gel electrophoresis, Vitexicarpin, a flavonoid found in chaste tree berry significantly inhibited proliferation of human cancer cells lines A2780(human ovarian carcinoma), HCT-15(human, colon, colorectal adenocarcinoma), HT-1080(fibrosarcoma cell line) and K562(Human chronic myeloid leukemia cells), depending to the concentration.

Dr. Wang HY the lead researcher in the study said, "Vitexicarpin induces apoptosis.... via mitochondria(in regulated cell metabolism)-controlled apoptotic pathway".

In support of the above analysis, the crude extract prepared with ethanol from dried ripened Vitex agnus-castus fruits exerted strong cytotoxic effects against cancer cell lines of human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.

The inhibition of the extract is attributed to the effect on cell death through apoptosis and increased intracellular oxidation in the tumor cells.

Other researchers suggested that the cytotoxic effects of Chaste tree berry may be involved various aspects, including the JNK (apoptosis) pathway. as indicated in the new native lignan VB6 study.

Taking together, there is no doubt, that chaste tree berry may be considered as a valuable chemotherapeutic agent for the treatment of various types of cancer, depending on further evaluation.



Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months



Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway].[Article in Chinese] by Wang HY1, Cai B, Cui CB, Zhang DY, Yang BF.(PubMed)
(2) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(3) Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway by Zhou J1, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y.(PubMed)

Yoga May Process Anti-Alcoholism Activity

By Kyle J. Norton

Scientists may have found an integrated form of exercise used combined with standard treatment in alcoholism, a joint study led by the Section of Epidemiology and Public Health Intervention Research (EPHIR), postulated.

Yoga, the ancient technique practice for harmonized external and internal body well being, through breath control, meditation, bodily movement, and gesture..... has been well known for people in the Western world and some parts in Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a study to examine 18 alcohol-dependent patients randomized received either treatment as usual or treatment as usual plus yoga has taken at baseline with six months follow-up for testing the effect of yoga therapy in reduced alcohol dependence, researchers filed the following results, after 10 weeks

1. Yoga was found to be a feasible and well-accepted adjunct treatment for alcohol dependence.

2. Yoga + conventional treatment showed a reduction in alcohol consumption from 6.32 to 3.36 drinks per day in comparison to other groups.

After taking into account other risk factors, researchers said, "Larger studies are needed to adequately assess the efficacy and long-term effectiveness of yoga as an adjunct treatment for alcohol dependence".

Other, in the study to evaluate the effect of a yoga intervention on alcohol and drug abuse behaviors in women with posttraumatic stress disorder (PTSD) through analyzed data from a pilot randomized controlled trial in comparing a 12-session yoga intervention and control of women age 18 to 65 years with PTSD, researchers found that
1. Yoga intervention at the end of the period expressed a significantly lower mean score of Alcohol Use Disorder Identification Test (AUDIT) in comparison to control
2. Yoga group also demonstrated a reduction in symptoms and improved symptom management. in most participants
3. Yoga participants expressed interest in psychological treatment

The findings suggested that yoga may play a role in attenuating the symptoms of PTSD, reducing the risk of alcohol dependence, and promoting interest in evidence-based psychotherapy.

More importantly, in the reviews, the philosophical origins, current scientific evidence, and clinical promise of yoga and mindfulness as complementary therapies for addiction, researchers at the joint study led by the Manipal University, said, " theoretical models suggest that the skills, insights, and self-awareness learned through yoga and mindfulness practice can target multiple psychological, neural, physiological, and behavioral processes implicated in addiction and relapse".

Further analysis, researchers concerned, "the clinical effectiveness and hypothesized mechanisms of action underlying mindfulness-based interventions for treating addiction" and "..very few studies have been conducted on the specific role of yoga in treating or preventing addiction".


Taking all together, yoga intervention may play an important role used in conjunction with standard therapy in treating alcoholism.


For More information on yoga lessons tailored to a complete well being for women, please visit: YOGA BURN


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Sources

Sources
(1)Yoga as an adjunct treatment for alcohol dependence: a pilot study by Hallgren M1, Romberg K2, Bakshi AS3, Andréasson S4.(PubMed)
(2) The effect of a yoga intervention on alcohol and drug abuse risk in veteran and civilian women with posttraumatic stress disorder by Reddy S1, Dick AM, Gerber MR, Mitchell K.(PubMed)
(3) A narrative review of yoga and mindfulness as complementary therapies for addiction by Khanna S1, Greeson JM.(PubMed)