Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.
In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a potential phytochemical for the treatment of diabetes, researchers examined the effect of α-tocopherol on bone marrow mesenchymal cells derived (BMMCs) from type II diabetes mellitus rats.
According to the experimental results of BMMCs either untreated or exposed to α-tocopherol at concentrations of 1.0, 10, and 100 μM, at the concentration of 100 μM, α-tocopherol showed no effect on cell proliferation, but the significantly increased H2O2 activity against the tested cells.
At 10 μM, α-tocopherol increased the gene expression of pro-inflammatory cytokines such as IL-1β and TNF-α.
According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
The most common forms of Diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutations and viruses.
* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body's metabolized glucose. In other words, most cases of type 2 diabetes are the result of insulin receptors clogged up by fat and cholesterol, leading to resisting the effects of the hormone insulin that regulates the movement of sugar into your cells.
About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.
The most common forms of Diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutations and viruses.
* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body's metabolized glucose. In other words, most cases of type 2 diabetes are the result of insulin receptors clogged up by fat and cholesterol, leading to resisting the effects of the hormone insulin that regulates the movement of sugar into your cells.
* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.
Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.
Oxidative stress is a condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes.
Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.
Oxidative stress is a condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes.
type 2
In some cases, oxidative stress can also be caused by the long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.On finding a potential phytochemical for the treatment of diabetes, researchers examined the effect of α-tocopherol on bone marrow mesenchymal cells derived (BMMCs) from type II diabetes mellitus rats.
According to the experimental results of BMMCs either untreated or exposed to α-tocopherol at concentrations of 1.0, 10, and 100 μM, at the concentration of 100 μM, α-tocopherol showed no effect on cell proliferation, but the significantly increased H2O2 activity against the tested cells.
Based on the findings, researchers said, "At a low concentration, α-tocopherol exerted good antioxidant and anti-inflammatory effects on BMMCs" and
"Maintaining α-tocopherol at a low concentration might promote the recovery of BMMCs from oxidative stress".
Taken altogether, tocopherols may be considered a functional food for the prevention and treatment of type 2 diabetes induced by oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of α-tocopherol on bone marrow mesenchymal cells derived from type II diabetes mellitus rats by Noguchi M1, Yamawaki I1, Takahashi S1, Taguchi Y1, Umeda M. (PubMed)
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