Type II diabetes is an acquired chronic and medical condition caused by insufficiency of insulin entering the bloodstream, leading to abnormally high blood glucose.
In other words, type II diabetes is due to the pancreas not producing enough insulin caused by the loss of beta cells or the body not properly using the insulin it makes as a result of insulin receptor sites clogged up by fat or cholesterol.
Although type II diabetes is a disease associated with adult-onset, today, the condition has been diagnosed in children at an alarming rate due to childhood obesity.
The most common symptoms of type II diabetes are increased thirst, frequent urination, unintended weight loss, and fatigue.
In severe cases, patients with type II diabetes also experience symptoms of slow-healing sores, frequent infections, and blurred vision.
Untreated type II diabetes may induce complications of diabetic retinopathy, kidney disease (nephropathy), diabetic neuropathy, and macrovascular problems.
As of today, there is no single cause and cure for type 2 diabetes. However, researchers suggested overweight, family history, aging, race, and medical conditions of prediabetes and gestational diabetes are some prevalent factors associated with the increased risk of the disease.c
Some researchers suggested that type 2 diabetes may be correlated to the promotion of the Western diet over the past few decades.
Dr. David Hefner in the article "Western Diet Linked to Type 2 Diabetes", wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains, and desserts-may increase your chances for Type 2 diabetes".
And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
In other words, if you are following a high-fat diet, you are at a higher risk of type II diabetes. is
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetes, researchers examined the effect of Curcumin (CUR; diferuloylmethane) in the increased oxidative stress and the proinflammatory state that contributes to the development and progression of the disease.
Oxidative stress is an imbalance between the production of reactive oxygen species (ROS) and their clearance by antioxidant defense mechanisms.
Curcumin improved the function of hepatic glucose and lipid metabolism which was dysfunctioned in patients with T2DM.
In vitro, curcumin was found to induce the liver protective effect in the regulation of glucose and lipid metabolism.
Furthermore, curcumin exerted antidiabetic potential by ameliorating skeletal muscle insulin resistance in rodents with diet-induced insulin resistance via an increase in the uptake and oxidation of fatty acids.
Moreover, curcumin was also found to improve insulin sensitivity in muscle tissue of insulin-resistant rodents by increasing cellular glucose uptake by enhancing the GLUT4 translocation.
In adipose tissue analysis, curcumin protected the adipose tissue function, by protecting the normal adipokine production, and FFA release, and preventing inflammation, that is associated with the pathogenesis of T2DM.
In pancreatic β-cells differentiation, curcumin enhanced the pancreatic β-cell function under diabetic conditions.
On metabolic dysfunction, curcumin improved the glycemic status and insulin sensitivity demonstrated in high-fat-diet- (HFD-) fed C57BL/6J mice and C57BL/6J ob/ob mice.
More recently, curcumin exerted a positive effect of CUR on metabolic abnormalities associated with T2DM which has been confirmed in high-fructose-fed Wistar rats by attenuating insulin resistance and glucose intolerance through its antioxidative and anti-inflammatory actions
Taken together, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention and treatment of type II diabetes, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Natural Products for the Treatment of Type 2 Diabetes Mellitus by Ríos JL1, Francini F2, Schinella GR. (PubMed)
(2) Molecular Mechanisms Underlying Curcumin-Mediated Therapeutic Effects in Type 2 Diabetes and Cancer by Wojcik M1, Krawczyk M1, Wojcik P2, Cypryk K3, Wozniak LA. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
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