Kyle J. Norton
Extracts of green tea may have a therapeutic and positive effect in protection against the development of all forms of acne, some scientists suggested.
Green tea is a precious drink with a number of health benefits known to almost everyone in Asia and the Western world.
Acne is a condition of skin disease characterized by the occurrence of inflamed or infected sebaceous glands in the skin.
Serious types of acne such as nodules and cysts burst and damage nearby skin can lead to forming of scarring.
In the examined the effects of EGCG, the bioactive major polyphenol of green tea on human SEB-1 sebocytes with function in secreted sebum in patients with acne, researchers found that EGCG exerted a significant antioxidant activity in reduced sebum secretion by modulating the AMPK -SREBP-1 signaling pathway through AMPK expression.
SEB-1 sebocytes is a human sebocyte culture model used intensively in studying sebaceous gland activity and regulating and treating acne.
The AMPK pathways played an essential role in the regulation of sebum production and secretion of sebaceous glands.
Application of green tea EGCG also demonstrated a strong effect in reduced sebum in the induction of inflammation of sebaceous glands, by suppressing
* The NF-κB in the induced transcription of proinflammatory genes in the cellular response to stress and pathogens and
* The AP-1 pathway, a transcription factor with function in regulated gene expression of inflammation factors in response to a variety of stimuli, including bacterial and viral infections.
Furthermore, administration of EGCG was also found to facilitate a huge effect in targeting almost all the pathogenic features of acne through exhibiting significant cytotoxicity of SEB-1 sebocytes in the induction of viability of cutibacterium (propionibacterium) acnes.
Dr. Yoon JY, the lead author at the Seoul National University Hospital, after taking into account all findings said, " EGCG significantly improved acne in an 8-week randomized, split-face, clinical trial, and was well tolerated".
Amazingly, the randomized, double-blind, placebo-controlled clinical trial conducted from May 2012 through October 2013, of a total of 64 of 80 women, from 25 to 45 years of age with moderate-to-severe acne randomly assigned to receive either 1500 mg of decaffeinated GTE or placebo (cellulose) daily for 4 weeks, there were statistically significant differences in inflammatory lesion counts found on the nose, periodically and on the chin between the two groups but no significant differences of total lesion counts.
Within the group, green tea application displayed significant reductions in inflammatory lesions distributed on the forehead and cheek with no difference in total lesion counts.
Moreover, the green tea group also significantly reduced total cholesterol levels compared to the cellulose group.
However, due to the limitation of the small sample and short time period, researchers postulated that more research is required to determine whether a decaffeinated GTE standardized for EGCG content will provide clinical benefits in women with post-adolescent acne.
Additionally, in selected 59 studies eight met the inclusion criteria to evaluate the effect of tea polyphenols in reduced sebum production in the skin and for treatment of acne vulgaris by reviewing the literature published on PubMed, researchers suggested that the application of tea polyphenols topically may have a beneficial effect in reduced sebum secretion and in treatment of acne through inhibited lipid synthesis by the sebaceous glands.
Truly, according to the University of Miami, in the examination, 12 patients with mild-to-moderate acne vulgaris received green tea application twice daily for a period of 6 weeks, topical injection of 2% green tea lotion was found to be effective in treatment with statistically significant in mean total lesion count (TLC) decreased from 24 measured at the baseline to 10 after 6 weeks treatment, a reduction of 58.33%.
The mean severity index (SI) from all patients also decreased from 2.05 before treatment to 1.25 after 6 weeks of treatment, a decrease of 39.02%.
Dr. Elsaie ML, the lead scientist said, "Topical 2% green tea lotion is an effective, cost-effective treatment for mild-to-moderate acne vulgaris".
Taking all together, green tea and its bioactive major polyphenol may be used safely in reduced risk, progression, and treatment of all forms of acne pending a large sample size and multi-center clinical trial.
Oral administration of green tea extract should be taken with exceptional care as some cases of acute liver toxicity were reported liter naturally.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea and Other Tea Polyphenols: Effects on Sebum Production and Acne Vulgaris by Saric S1, Notay M2, Sivamani RK(PubMed)
(2) Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial by Lu PH1, Hsu CH2.(PubMed)
(3) Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes by Yoon JY1, Kwon HH, Min SU, Thiboutot DM, Suh DH. (PubMed)
(4) The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris by Elsaie ML1, Abdelhamid MF, Elsaaiee LT, Emam HM. (PubMed)
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