Kyle J. Norton
Green tea showed to inhibit or exhibited kidney function in toxin elimination in deteriorated renal function in patients with chronic renal disease, studies proposed.
Renal Disease is an impaired function in toxin elimination for more than a specific time as a result of kidney damage or injury.
Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will be helpful to solve the problem.
In mice fed with a powdered diet containing green tea polyphenolic extract (0.1%) starting 3 days prior to CsA treatment (25 mg/kg, i.g. daily for 3 weeks).showed a decreased renal nuclear DNA-encoded oxidative phosphorylation (OXPHOS) protein ATP synthase-β (AS-β)by 42%, mitochondrial DNA (mtDNA)-encoded OXPHOS protein NADH dehydrogenase-3 (ND3) involved oxidize nutrients for energy conversion by 87%.
Flavanols (polyphenols) are rich phytochemicals isolated from green tea, particularly in the expression in the form of the most bioactive flavanol EGCG.
Oxidative phosphorylation (OXPHOS) protein ATP synthase-β (AS-β) plays a key role in energy production and regulated the generation of free radicals, and apoptosis through the respiratory chain.
Mitochondrial DNA (mtDNA)-encoded OXPHOS protein NADH dehydrogenase-3 (ND3) in reduced risk of gene mutation through oxidative phosphorylation (OXPHOS).
Dr. Rehman H, the lead author said," Green tea polyphenols markedly attenuated CsA-induced renal injury and improved renal function. Together, these results demonstrate that green tea polyphenols attenuate CsA-induced kidney injury, at least in part, through the stimulation of MB".
In support of the efficacy of green tea for the treatment of renal disease, the study of F40 rats was randomly divided into 4 groups. Group 1 acted as control; group 2 received contrast medium (intravenous iodixanol, 10 mL/kg, as a single dose); group 3 received contrast medium and then green tea extract for 3 days (10 mg/kg/d, intraperitoneal); and group 4 first received green tea and then contrast medium, researchers showed that group treated with green tea had significantly higher overall scores than the control group.
The treatment group also expressed a significant improvement in the progression of renal degeneration caused by nephrotoxicity of contrast media.
Unfortunately, according to the joint study led by the China Medical University, inhibited the elimination of indoxyl sulfate (IS) and p-cresyl sulfate (PCS), highly protein-bound nephron-cardiovascular toxins in CRF rats.
Catechin is another major chemical constituent isolated from Green tea (GT) and a popular beverage in China.
Indoxyl sulfate(IS), a circulating uremic toxin has been found to be associated with the development of glomerular sclerosis and interstitial fibrosis.
P-Cresyl sulfate (pCS) is also a uremic toxin generated by intestinal bacteria
which has an implication to worsen outcomes of patients with chronic kidney disease and increased cardiovascular burden.
Furthermore, green tea injection of catechin. in the experiment mice also showed significantly increased levels of serum creatinine (Cr) and blood urea nitrogen (BUN), an indication of further kidney damage after ingestion of green tea catechin.
Dr. Peng YH, the lead author said, "GT inhibited the elimination of nephron-cardiovascular toxins such as IS and PCS, and deteriorated the renal function in CRF rats".
Taking together, the conflict results of green tea in the expression of chronic renal disease may be due to study design, the group sample, the subject selection doses administration,........., therefore patients with renal disease should consult with specialists before taking.
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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Green tea inhibited the elimination of nephron-cardiovascular toxins and deteriorated the renal function in rats with renal failure by Peng YH1, Sweet DH2, Lin SP1, Yu CP1, Lee Chao PD1, Hou YC1,3,4.(PubMed)
(2) Green tea polyphenols stimulate mitochondrial biogenesis and improve renalfunction after chronic cyclosporin a treatment in rats by Rehman H1, Krishnasamy Y, Haque K, Thurman RG, Lemasters JJ, Schnellmann RG, Zhong Z.(PubMed)
(3) Ameliorative effect of green tea against contrast-induced renal tubular cell injury by Nasri H, Hajian S, Ahmadi A, Baradaran A, Kohi G, Nasri P, Rafieian-Kopaei M1.(PubMed)
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