Kyle J. Norton
Compared to herbal medicine; food therapy may even take longer to ease symptoms, depending on the stage of the treatment which directly addresses the cause of the disease.
Adding a portion of beet to your daily diet may have a significant effect on improved blood circulation through anti-platelet aggregation and anti-hypertension activities, a recent and renowned study suggested.
Platelet aggregation is the natural reaction of the wound healing process of blood clotting in damage and injury of our body, to prevent infection and inflammation.
Beet, best known as the beetroot or garden beet and belongings to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the Barts & the London School of Medicine and Dentistry, dietary rich in nitrate vegetables or fruit, such as beet showed to exhibit vascular function in the promotion of blood vessel and blood circulation function, thus reducing the risk of CVD.
In healthy volunteers, ingestion of a dietary nitrate load (beetroot juice 500 mL), approximately 3 hours after, correlated with peak increases in plasma nitrite concentration showed a significant effect in attenuated platelet aggregation in response to collagen and adenosine diphosphate (ADP), in cell energy metabolism. And decreased plasma nitrite may block the decrease in blood pressure and abolished the inhibitory effects on platelet aggregation.
These findings suggested that regular drinking of dietary nitrate from food sources is necessary for the maintenance of a healthy heart through decreased platelet aggregation and reduced blood pressure.
In 2 randomized crossover studies each in 24 (12 of each sex) healthy subjects with orally administrated dietary nitrate (250 ml beetroot juice) or potassium nitrate capsules (KNO3, 8 mmol) vs placebo control on platelet reactivity, researchers found that the group treated with nitrate component shows a strong inhibition of platelet aggregation.
The study also demonstrated that inorganic nitrate ingestion, whether via diet or through supplementation, may have a gender preference in decreased platelet reactivity in healthy males but not females counterparts.
Dr. Velmurugan S, the lead author said, "Dietary nitrate (maybe a benefit) as an adjunct to current antiplatelet therapies to prevent atherothrombotic complications".
Furthermore, according to the review of the National Heart and Lung Institute, in vitro and in vivo, dietary nitrite exhibited cGMP in mediating the levels of platelet aggregation through an expression of nitric oxide actions,
And, in a model of thromboembolic radiolabeled platelet aggregation, injection of dietary nitrate or supplement showed a significantly inhibited platelet function in eNOS(-/-) mice.
Cyclic guanosine monophosphate (cGMP), a cyclic nucleotide plays both a stimulatory and an inhibitory role in platelet activation depending on concentration and timing.
NO also are best known for its function in regulating blood pressure and impaired NO bioactivity is an important component of hypertension
Collectively, beet with a high amount of dietary nitrate may be used as functional food combined with conventional treatment in reducing the risk of platelet aggregation and hypertension in the induction of CVD.
People who are taking anti-platelet aggregation medicine should consult with their doctors before applying large amounts of beet juice or juice with high concentrations of nitrate.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299
Sources
(1) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite by Webb AJ1, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A.(PubMed)
(2) Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex by Velmurugan S1, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A, Ahluwalia A.(PubMed)
(3) Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo by Apostoli GL1, Solomon A, Smallwood MJ, Winyard PG, Emerson M.(PubMed)
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