Friday, 21 May 2021

Omega -3 Fatty Acids showed No Effects on Prostate Tissues in a Short Duration

By Kyle J. Norton

Prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder.

The prostate gland is a gland that makes and stores semen located below the bladder that carries urine out of your body.

Prostate enlargement is the condition that the prostate gland has grown bigger. The condition has been found in almost all aging males.

More precisely, by the age of 40, the levels of testosterone of men start to decrease resulting in the increase of the by-product prolactin of testosterone that stimulates the production of the enzyme 5-alpha reductase induce-the conversion of testosterone to dihydro-testosterones DHT that trigger prostate enlargement and prostate cancer. 

Excess estrogen seems to be the culprit in the prostate enlargement that leads to the pathology and favors the development of prostate cancer.

Cancer is a class of diseases in which a group of abnormal growth of cells has become progressively worse as it intrudes upon and destroys adjacent tissues, sometimes spreads to other organs in the body via lymph or blood and results in the death of the host.

Most cases of prostate cancer begin in the cells on the surface of the inner lining of the prostate tissue before penetrating into deeper layers to induce colonization.

At the advanced stage, the prostate cancer cells can spread to the distant parts of the body, leading to secondary metastasis.

According to the statistics, prostate cancer is the most common cancer among men particularly in older over 65, after skin cancer. in 2019, approximately 174,650 men in the US will be diagnosed with prostate cancer.

The average age of diagnosis is 66.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of prostate diseases, researchers evaluated the independent and joint effects of fish oil (FO) and green tea supplement (epigallocatechin-3-gallate, EGCG) on FAS and Ki-67 levels in prostate tissue.

A double-blinded, randomized controlled trial with 2 × 2 factorial design included a total of 89 men scheduled for repeat prostate biopsy following an initial negative prostate biopsy randomized into either FO alone (1.9 g DHA + EPA/day), EGCG alone (600 mg/day), a combination of FO and EGCG, or placebo.

According to the tested analysis, there were no significant differences among treatment groups in pre-to-post-intervention changes of FAS associated with the production of a pro-inflammatory family tumor necrosis factor.

Furthermore, compared to the placebo group, treatment groups did not show a significant difference in FAS or Ki-67 changes involved in worse outcomes of the tumor.

Based on the findings, researchers said, "FO or EGCG supplementation for a short duration may not be sufficient to produce biologically meaningful changes in FAS or Ki-67 levels in prostate tissue".

Taken altogether, Omega-3 fatty acids in a short during found abundantly in fish oil and plant oil have no effects on the prostate tissues, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of ω-3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial by Zhang Z1, Garzotto M2, Beer TM3, Thuillier P1,3,4, Lieberman S5, Mori M1,3, Stoller WA1, Farris PE1, Shannon J. (PubMed)
(2) Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer by Christensen JH1, Fabrin K, Borup K, Barber N, Poulsen J. (PubMed)

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