Bile duct, the tube-like structure carries bile to the intestine for food digestion secreted by the liver.
In other words, bile acid plays a critical for digestion and absorption of fats and fat-soluble vitamins in the small intestine.
More importantly, many waste products, such as bilirubin, are eliminated from the body by secretion into bile and elimination in feces.
Cholangiocarcinoma, also known as bile duct cancer, is a medical condition that originated from the irregular cell growth in the bile ducts.
Most cases of cholangiocarcinoma are caused by the alternation of cell DNA in the cell on the surface of the inner lining of the bile duct.
At the advanced stage, cancer cells in the bile duct may travel a distance away to infect other healthy tissues and organs through the circulation of blood and fluids.
The primary bile duct cancer has been found to spread to the regional lymph nodes and adjacent organs.
According to statistics, cholangiocarcinoma is rare cancer that occurred approximately 2500 Americans each year compared to 5000 cases of gallbladder cancer and 15,000 cases of hepatocellular cancer.
Believe it or not, the 5-year survival rate diagnosed at early-stage extrahepatic bile duct cancer is only 30%.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the
omega-3 fatty acid effects on human cholangiocarcinoma cells (CCA).
According to the final results of the experiment,
* n-3 PUFA-based fish oil suppresses CCA cell growth, potentially by blocking the cell cycle at G2/M phase,
* n-3 PUFA also inhibited the migration and invasion potential with coincident downregulation of migration-related genes.
* Furthermore, zebrafish endogenous n-3 PUFAs appear to suppress CCA metastasis by inhibiting the expression of twist, a key regulator of tumor metastasis.
Most importantly, only long-chain n-3 PUFAs could inhibit the expression of twist in CCA cells.
Cholangiocarcinoma, also known as bile duct cancer, is a medical condition that originated from the irregular cell growth in the bile ducts.
Most cases of cholangiocarcinoma are caused by the alternation of cell DNA in the cell on the surface of the inner lining of the bile duct.
At the advanced stage, cancer cells in the bile duct may travel a distance away to infect other healthy tissues and organs through the circulation of blood and fluids.
The primary bile duct cancer has been found to spread to the regional lymph nodes and adjacent organs.
According to statistics, cholangiocarcinoma is rare cancer that occurred approximately 2500 Americans each year compared to 5000 cases of gallbladder cancer and 15,000 cases of hepatocellular cancer.
Believe it or not, the 5-year survival rate diagnosed at early-stage extrahepatic bile duct cancer is only 30%.
On finding a potential phytochemical for the treatment of chronic diseases, researchers examined the
omega-3 fatty acid effects on human cholangiocarcinoma cells (CCA).
According to the final results of the experiment,
* n-3 PUFA-based fish oil suppresses CCA cell growth, potentially by blocking the cell cycle at G2/M phase,
* n-3 PUFA also inhibited the migration and invasion potential with coincident downregulation of migration-related genes.
Based on the findings, researchers said, " n-3 PUFAs, especially DHA, may inhibit proliferation and metastasis of CCA cells by inhibiting the expression of a twist".
Taken altogether, long-chain omega-3 fatty acids may be considered a functional food for the prevention and treatment of cholangiocarcinoma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Omega-3 polyunsaturated fatty acids suppress metastatic features of human cholangiocarcinoma cells by suppressing twist by Lin CR1, Chu TM2, Luo A2, Huang SJ2, Chou HY3, Lu MW3, Wu JL. (PubMed)
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Omega-3 polyunsaturated fatty acids suppress metastatic features of human cholangiocarcinoma cells by suppressing twist by Lin CR1, Chu TM2, Luo A2, Huang SJ2, Chou HY3, Lu MW3, Wu JL. (PubMed)
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