Monday 31 May 2021

Omega 3 Fatty Acids, the Natural Cholesterol Lowering Remedy, Scientists Say

By Kyle J. Norton

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.

High blood cholesterol is the most common cause of hyperlipidemia.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, produces vitamin D and steroid hormones.

The healthy ratio of low-density lipoprotein (LDL)/high-density lipoprotein (HDL) is ant numbers that are less than 4.

People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances form plague, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to the parts of the body.

According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

About half of the U.S. adults (55%, or 43 million) are currently taking medicine associated with lower blood cholesterol.

There are many risk factors that cause the onset of hyperlipidemia, such as people with diabetes, being overweight gain, physical activity, and smoking.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the Omega 3 fatty acid activity on blood lipid and lipoprotein profiles in patients with dyslipidemia receiving hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins).

According to phase 4, randomized, open-label study, included 50 patients with dyslipidemia receiving statins randomized 1:1 to Omega-3 treatment (oral Omega-3 2 g twice daily) or Control (no Omega-3),
* LDL particle size in Omega-3 treatment group showed a significant effect at week 8, compared to control.

* Furthermore, the differences in least squares mean change in concentration from baseline to week 8 between Omega-3 and Control groups were significant for total cholesterol (p = 0.0009), LDL-C (p = 0.0442), non-high-density lipoprotein cholesterol (p = 0.0009), and remnant lipoprotein-cholesterol (p = 0.0396).

* Moreover, the differences were significant for all apolipoproteins that that bind lipid (fat and cholesterol) to form lipoproteins. but not apolipoprotein E.

In other words, Omega 3 showed strong activity against the overexpression of cholesterol in the induction of hyperlipidemia.

Based on the results, researchers said, "Significant increases in LDL particle sizes and significant decreases in blood lipid, lipoprotein and apolipoprotein concentrations were observed with Omega-3 compared with Control. Omega-3 may improve blood lipid profile and increase LDL particle size, resulting in an anti-atherogenic profile:.

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of dyslipidemia and hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 fatty acid ethyl esters improve low-density lipoprotein subclasses without increasing low-density lipoprotein-cholesterol levels: A phase 4, randomized study by Masuda D1, Miyata Y2, Matsui S2, Yamashita S. (PubMed)

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