Saturday 8 May 2021

Tocopherols, the Anti Cardiovascular Diseases (CVD) Antioxidants

By Kyle J. Norton

The heart formed part of the circulatory system is a muscular organ that pumps blood through the blood vessels to nourish the body tissues and organs.

Most cases of heart dysfunction are associated with the reduced function of the heart muscle, leading to reduce blood flow that facilitates heart failure and the backup of blood into the lungs or rest of the body.

According to the statistics provided by the US government, heart disease is a leading cause of death in the US. Over 600,000 died of heart disease, every year including 370,000 people died of coronary heart disease (CHD), accounting for 1 in 4 deaths.


Cardiovascular disease (CVD) is a group of conditions associated with the heart and blood vessels.

Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.

Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.

The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, causing damage to the heart tissue and reduced function of the arteries.

Believe it or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware of heart disease risk in them, according to the Jean Hailes for Women Health in the article cardiovascular health.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of chronic diseases associated with inflammation, researchers examined the effects of α‐tocopherol on CVD.

Dietary antioxidant supplementation in humans and α‐tocopherol supplementation (1600 mg/d) caused greater protection of LDL from oxidation in vitro assays. 

 α‐tocopherol would reduce atherosclerosis‐related events without adverse effects.

Patients who took α‐tocopherol showed a decrease of LDLoxidation by 50%.

Treatment with α‐tocopherol (400–800 mg/d) reduced the risk of nonfatal MI in patients with angiographically proven coronary atherosclerosis.

Additionally, the  Cambridge Heart Antioxidant Study (CHAOS) in 1996, the demonstrated that α‐tocopherol (400–800 mg/d) significantly reduced the risk of nonfatal myocardial infarction (MI) in patients with angiographically proven coronary atherosclerosis;

Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of diseases related CVD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tocopherols in the Prevention and Treatment of Atherosclerosis and Related Cardiovascular Disease by Mathur P1, Ding Z1, Saldeen T1, Mehta JL. (PubMed)

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