Thursday, 10 November 2016

Regular Walking Reduced Risk of Early Onset, Progression and Symptoms of Alzheimer's disease in Older Adults

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Regular physical activity has long been found to associate to the prevention of cancer, cardiovascular disease, and other chronic diseases, but regular walking contribution of reduced risk and progression of Alzheimer's disease in the younger and older elderly patient have been lacking, probably due to in reversibility in disease controlling(1) and in most cases in older adults(2).

Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal, due to progression of formation of plaques and tangles.

Strengthening immune system fights against inflammation, reduce high blood pressure, lower cholesterol levels and healthy diet will help to prevent Alzheimer's disease(3).

New study conducted by the São Paulo State University, multimodal exercise, including walking intervention on frontal cognitive functions and kinematic gait parameters may be effective to prevent the progression in patients with Alzheimer's disease(4).

According to a study of the performance of exercise program such as walking, of 134 ambulatory patients with mild to severe AD, significantly improved ability to perform activities of daily living (ADLs), physical performance, and nutritional and decreasing behavioral disturbance and depression in patients(5).

In support of regular walking in improvement of cognitive and physical function in AD patients, Dr. Vreugdenhil A and colleagues at the University of Tasmania, said, " participation in a community-based exercise programme can improve cognitive and physical function and independence in ADL in people with Alzheimer's disease,.... under the supervision of their carer.(6),
In fact, regular walking in elderly exercise program also showed to slow the rate of functional deterioration in mild AD and reduce falls and disease progression(8) in patients suffering from advanced AD(7), a major concern of caregivers, through improvement of balance performance(8).

Dr. Ryan SM and colleagues in the study of examined exercise-mediated effects on AD pathology, cognitive function, hippocampal neurogenesis and neuroinflammation in transgenic mouse models of AD, concluded, "exercise presents a promising non-pharmacological option to potentially delay the onset of or slow down the progression of AD"(9) through " induced effects on hippocampal neurogenesis, cognitive function and neuroinflammation, and considerexercise as a potential pro-neurogenic and anti-inflammatory intervention for cognition"(10)

Some researches suggested that the effectiveness of exercise in delay the onset of or slow down the progression of AD by preventing amyloid-β (Aβ) load, probably is the results of exercise induced protection against AD-related mitochondrial dysfunction and phenotypic deterioration(11).

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(1) iPSCs: On the Road to Reprogramming Aging by Soria-Valles C1, López-Otín C2.(PubMed)
i(2) Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study BY Burnham SC1, Bourgeat P2, Doré V3, Savage G4, Brown B5, Laws S6, Maruff P7, Salvado O2, Ames D8, Martins RN9, Masters CL10,Rowe CC11, Villemagne VL12; AIBL Research Group.(PubMed)
(3) Regular Walking of 50+ to the World of Diseases Free and Longevity(Research and Studies) by Kyle J. Norton
(4) Multimodal exercise intervention improves frontal cognitive functions and gait in Alzheimer's disease: a controlled trial by Coelho FG1, Andrade LP, Pedroso RV, Santos-Galduroz RF, Gobbi S, Costa JL, Gobbi LT.(PubMed)
(5) Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial BY Rolland Y1, Pillard F, Klapouszczak A, Reynish E, Thomas D, Andrieu S, Rivière D, Vellas B.(PubMed)
(6) A community-based exercise programme to improve functional ability in people withAlzheimer's disease: a randomized controlled trial by Vreugdenhil A1, Cannell J, Davies A, Razay G.(PubMed)
(7) Effects of Exercise on Functional Performance and Fall Rate in Subjects with Mild or Advanced Alzheimer's Disease: Secondary Analyses of a Randomized Controlled Study by Öhman H1, Savikko N, Strandberg T, Kautiainen H, Raivio M, Laakkonen ML, Tilvis R, Pitkälä KH.(PubMed)
(8) Effectiveness of balance training exercise in people with mild to moderate severity Alzheimer's disease: protocol for a randomised trial by Hill KD1, LoGiudice D, Lautenschlager NT, Said CM, Dodd KJ, Suttanon P.(PubMed)
(9) Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease by Ryan SM1, Kelly ÁM2.(PubMed)
(10) Neuroinflammation negatively affects adult hippocampal neurogenesis and cognition: canexercise compensate? Ryan SM1, Nolan YM2.(PubMed)
(11) Exercise-induced neuroprotection of hippocampus in APP/PS1 transgenic mice via upregulation of mitochondrial 8-oxoguanine DNA glycosylase by Bo H1, Kang W2, Jiang N3, Wang X3, Zhang Y3, Ji LL4.(PubMed)

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