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Friday, 30 September 2016

Antioxidants: Liver Disease - The Effects of Free radicals on Liver disease

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.

                      

                           Liver Disease

Liver disease is defined as a broad term describing any single number of diseases affecting the liver, leading to liver inflammation or tissue damage and affects liver function. Beside forming part of immune system, it also converts nutrients into essential blood components, stores vitamins and minerals, etc.


                   The Effects of Free radicals on Liver disease


1. Alcohol
Reseachers found that both acute and chronic alcohol exposure can increase ROS damage or cause peroxidation of essential complex molecules in the cells, including lipid peroxidation, proteins, and DNA.

2. Polyunsaturated fatty acids
Researchers found that the free radical chain reaction not only succeeds in destroying a sufficient amount of membrane polyunsaturated fatty acids, but also give rise of poison shortly causing liver diseases.

3. 8-hydroxyl-2-deoxyguanosine
High levels and chain free radicals reaction found in liver as a result of increased levels of 8-hydroxyl-2-deoxyguanosine which induces the alteration of normal pairing of DNA double helix.

4. Glutathione
Researchers found that inducing oxiadive stress reduces the liver function and glulathione levels but increases in the protein carbonyl levels, leading to protein oxidation.

5. Lipid peroxidation
Oxidative stress also increases the production of free radical by depleting the liver of its antioxidants.

6. Mitochondrial membrane
Excessive consumption can impair the permeability of mitochondrial membrane in the liver cell by depleting the levels of glutathione levels and increasing the rate of apoptosis.



7. Etc.
 
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