Wednesday, 21 September 2016

Antioxidants: Diabetes: The effects of Free radicals on diabetes Secondary condition

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Human aging is a biological process, no one can stop, but delay it. It is possible that one person has a physiological younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.



Diabetes is defined as a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced.

        Free radicals on diabetes Secondary condition

a. Endothelial dysfunction
ROS may alter endothelial function directly by causing the upregulation of adhesion molecules to platelets and leukocytes and decreasing the bioavailability of NO that promotes oxidation of low density lipoprotein (LDL), leading to diabetic vascular disease.

b. Diabetes mellitus
Inability in the regulation of peroxide and transition metal metabolism may result in the establishment of the disease as well as its longer term complications such as atherosclerosis, kidney and nerve damage as well as blindness.

c. Xanthine Oxidase
Xanthine Oxidase is a form of xanthine oxidoreductase that generates reactive oxygen species. Study showed that xanthine oxidase activity increases in type I diabetic animals and that this is a significant cause of the oxidative stress which occurs in the disease.

d. Alloxam
Alloxam can cause type I diabetes by destroying the islet of Langerhans in the pancreas as it gives rise to hydrogen peroxide, superoxide and hydroxyl radicals.

e. AGEs
AGEs or advance glycation end products is produced by elevating levels of free radicals activity due to oxidative stress, causing the decrease of the elasticity of extracecullar compartment, impending the flow of nutrients and waste production.

f. Etc.

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