Tocopherols Inhibits The Liver Oxidative Stress

By Kyle J. Norton

Oxidative stress is a condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes produced by the host tissue.

In other words, oxidative stress is either caused by overexpression of free radicals or depletion of antioxidant enzymes in the body.

Some researchers suggested that oxidative stress may also arise due to the chain reaction of free radicals in which free radicals donate or intercept an electron from other stable molecules.

Long-term oxidative stress present in the body can cause protein and lipid damage and alternation of cell DNA, leading to the onset of chronic diseases, including cardiovascular disease, diabetes, and cancer.

In some cases, this reaction also is caused long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

There is no single cause of oxidative stress. Some researchers suggested that a number of factors can facilitate the onset of oxidative stress, including cigarette smoke, and oxidative burst from activated macrophages, particularly, the free radicals chain reaction.

Sadly, a prolonged period of oxidative stress present in the human body can cause oxidative damage to biomolecules, (lipids, proteins, DNA) and the death of healthy cells through cytotoxicity.

Certain chronic diseases are found to be associated with oxidative stress, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, seed or nut oils, etc.

On finding a potential phytochemical for the treatment of diseases associated with oxidative stress, researchers examined the curative efficacy of L-Ascorbic acid (L-AA) and α-Tocopherol (α-TOC) against Arsenic trioxide (As2O3) toxicity using immortalized human Chang liver cells.

According to the analysis,
* L-AA (100 µM) and α-TOC (50 µM) recovered As2O3 (10 µM) cytotoxicity.

* As2O3 treatment showed an increase in lipid peroxidation and depletion in antioxidant status, mitochondrial transmembrane potential, and values of total antioxidant capacity.

* Cotreatment of antioxidant vitamins with As2O3 resulted in a significant reversal of oxidative stress markers.

Based on the results, researchers said, "substantiate the effect of antioxidant vitamins in protecting the hepatocytes from oxidative stress which may be attributed through Nrf2 (Nuclear factor erythroid 2-related factor 2) mediated upregulation of Bcl2 (B-cell lymphoma 2) expression".

Taken altogether, tocopherols may be considered a supplement for reducing the risk of liver oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) L-Ascorbic Acid and α-Tocopherol Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells by Vineetha RC1, Archana V1, Binu P1, Arathi P1, Nair RH. (PubMed)

Maternal Coffee and Coffee Caffeine Intakes May Increase the Risk of Poor Child Cognition and Behavior, Researchers Say

By Kyle J. Norton

Food therapy is a slowly recovering but effective method used in traditional medicine to ease symptoms and treatment of diseases, depending on the stages of the treatment which directly addresses the roots of the cause without inducing adverse effects.

Epidemiological studies do not agree that coffee and coffee caffeine intake during pregnancy may have a negative impact on child cognition and behavior.

Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.

Caffeine, a chemical stimulant found abundantly in caffeinated products, including tea and coffee is a class of methylxanthine having a profound impact on the central nervous system (CNS).

Cognition and Behavior is a group of neuro functions involving sensation and perception, learning and memory, attention, mental imagery, conceptual presentation, language expression, emotion response, and motor control,.....

In the study of examining maternal serum paraxanthine at <20 and ≥26 weeks' gestation with the child's intelligence quotient (IQ) and problem behaviors at ages 4 and 7 years among 2,197 mother-child pairs, researchers showed that paraxanthine, a structurally related to caffeine.and caffeine's primary metabolite concentration has a significantly inverted effect at ≥26 weeks' gestation with child's IQ at age 7 years.

And at <20 weeks, paraxanthine also expressed a linearly associated with internalizing behavior at age 4 years.

Paraxanthine is a caffeine metabolite and central nervous system (CNS) stimulant processed a similar potency equal to that of caffeine.

Interestingly, after taking into account a range of values applicable to most pregnant women, researchers indicated that coffee caffeine in contribution to serum paraxanthine concentration showed no significant effect in association with childhood IQ or problem behaviors.

In contrast to the healthy mothers, women's reported coffee intake per day during pregnancy was associated with a lower child's behavior rating scale (BRS), a complete overview of child and adolescent concerns and disorders, and ratings in anemic children. Even with the inclusion of other contributing factors and after anemic children were given appropriate treatment, coffee consumption continuously showed poor child cognition and behavior.

The Behavior Rating Scale (BRS) is an assessment frequently used by experts in the assessment of the development of child cognition and behavior in infants and children, including autism.

Dr.Engle PL, the lead author said, " The effects of postnatal coffee ingestion in Guatemala were seen for sleep duration, but not for cognitive development. Prenatal coffee ingestion was negatively associated with behavior rating scales".

Taking all together, coffee caffeine intake during pregnancy may not have any meaningful effect in association with children's cognitive development and measurement by behavior rating scales, excluding anemic children. But caffeine as a neural stimulant may have a negative impact on the brain function by altering fetal normal neural transmission during a stage of brain development, some researchers are concerned.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Maternal Caffeine Intake During Pregnancy and Child Cognition and Behavior at 4 and 7 Years of Age by Klebanoff MA, Keim SA.(PubMed)
(2) Effects of discontinuing coffee intake on iron-deficient Guatemalan toddlers' cognitive development and sleep by Engle PL1, VasDias T, Howard I, Romero-Abal ME, Quan de Serrano J, Bulux J, Solomons NW, Dewey KG.(PubMed)

Beta-Sitosterol Processes Hypolipidemic Activity

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million American and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

People with hyperlipidemia are asymptomatic. However, if untreated, the condition can cause cholesterol build-up on the arterial wall, leading to narrowing the arteries inducing blockage that causes heart disease and stroke.

The most common inherited form of high blood cholesterol is called familial hypercholesterolemia found in 1/500 people.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention of diseases involved in high blood cholesterol, researchers investigated β-sitosterol ester with linoleic acids and β-sitosterol self-microemulsions preparation on hyperlipidemia mice.

Selected mice were randomly divided into normal group and model group, fed with a basic diet and high-fat diet for 70 days respectively. 

After high-fat model mice were successfully established, the model group was further divided into eight groups: HFD (high-fat diet feeding), SELA-TSO(8 ml/kg, SELA:700 mg/kg), TSO (8 ml/kg), SSSM (8 ml/kg,SS:700 mg/kg), NLSM (8 ml/kg), SSHT-TSO (8 ml/kg, SS: 700 mg/kg) and SS-TSO (8 ml/kg, SS: 700 mg/kg) groups, and treated with β-sitosterol ester with linoleic acid, β-sitosterol self-microemulsion, commercial β-sitosterol health tablets, and β-sitosterol powder for 35 days, respectively.

Based on the results of the experiment,

* β-sitosterol self-microemulsion has the highest anti-hyperlipidemic effect among the experimental groups, compared to β-sitosterol ester with linoleic acids.

* The anti-hyperlipidemic effects are listed as SSSM> SELA-TSO > SSHT-TSO > SS-TSO.

Collectively, researchers said, "a new formulation of β-sitosterol was developed, and its hypolipidemic effect was investigated. The results showed that β-sitosterol self-microemulsion has a good blood lipid-lowering effect".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of β-sitosterol self-microemulsion and β-sitosterol ester with linoleic acid on lipid-lowering in hyperlipidemic mice by Yuan C1, Zhang X1, Long X1, Jin J1, Jin R. (PubMed)

Herbal Butterbur May Process Anti Acute and Chronic Migraine Activity

By Kyle J. Norton

Herbal butterbur may be considered a functional herb in the protection of neurons against change in the brain and its surrounding blood vessels in the initiated onset of migraine, some scientists suggested.

Migraine headache is one most common headaches defined as a condition of a chronic neurological disorder of moderate to severe headaches, and nausea that usually develops gradually over 5–20 minutes and lasts for less than 60 minutes.

According to statistics, the syndrome affects over 15% of the population in the US. If you are a woman your risk of migraine headaches is 2 times higher in compared to men.

Sadly, 1 in 7 people in the world population will develop migraine headache at some point in their lifetime, And, chronic migraine affects about 2% of the world population.

Some patients during migraine attacks also suffer symptoms of visual disturbances, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch, and smell, and tingling or numbness in the extremities or face.

Believe it or not, 10% of school-age children also suffer from undiagnosed migraine headaches.

Conventional medicine in reducing symptoms of pain during attacks such as Sumatriptan, Rizatriptan,..and Eletriptan may be effective but they may induce certain side effects, including gastrointestinal discomfort, dizziness, drowsiness,... and muscle weakness.


Please make sure that you discuss these side effects with your doctor before taking them.


Butterbur, found in wet, marshy, damp land, including wetland, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.

The herb has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.

The Chemical constituents
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

Although the herb is used as a nutritional supplement in the US, scientific studies suggested that it may be used as the prevention of allergic rhinitis and treatment of migraine.

In a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine, satisfied the International Headache Society criteria, researchers found that by calculating the migraine attack frequency per month as percentage change from baseline over a 4-month treatment period

* Migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), in compared to 26% of placebo group.

* The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05).
* In comparison to the baseline, patients, intake of Petasites 75 mg also expressed a significant effect in reduced migraine at 1, 2, and 3 months.

* Mild adverse effects such as gastrointestinal events, predominantly burping. were also reported.

These results suggested that butterbur Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine.

Furthermore, in the review to confirm the strength of evidence of effectiveness for Petasites hybridus in treating prophylaxis of migraine by searching several databases and other sources to identify randomized-controlled trials, the Headache Center Hirslanden in Zürich, Switzerland found 2 trials totaling 293 patients (60 and 233 patients).

According to the selected trials, oral administrated butterbur extract at a higher dose (150 mg) expressed a greater decreased frequency of migraine attacks and a greater number of responders (improvement>50%) after treatment over 3-4 months compared to the extract at a lower dose (100 mg) and placebo.

Additional differentiation also found some evidences that higher than the recommended dose may be more effective in treating prophylaxis of migraine.

More profoundly, in the study of 60 patients who received either the special Petasites hybridus extract Petadolex or placebo at a dosage of two capsules (each capsule contains 25 mg) twice daily over 12 weeks, researchers found that

* Oral injection of the capsules Petadolex reduces the frequency of migraine attacks decreased by a maximum of 60 percent compared to the baseline.

* No adverse events were reported. Petasites were exceptionally well tolerated.

Taking all together, herbal butterbur extract may be considered a therapeutic treatment for acute and chronic migraine headaches, however, the exact dose should only be prescribed by herbalists.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca


Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
References
(1) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine by Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A.(PubMed)
(2) An extract of Petasites hybridus is effective in the prophylaxis of migraine by Grossman W, Schmidramsl H.(PubMed)
(3) Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review by Agosti R, Duke RK, Chrubasik JE, Chrubasik S.(PubMed)

Herbal Chaste Tree Berry (Vitex Agnus-castus) May Process Anti-Leukemia Potency

By Kyle J. Norton

Scientists may have found a herbal ingredient for the treatment of leukemia with no side effects, some studies suggested.

Leukemia is a medical condition characterized by the production of high numbers of abnormal white blood cells. A disease is a group of cancers originating in the soft, inner part of the bones (bone marrow).

At the advanced stage, the cancerous cells can travel a distance away to infect other healthy cells of other tissue and organs, particularly, in the tissue of lymph nodes, spleen, liver, and central nervous system.


The exact causes of leukemia are unknown, however, researchers do know that smoking, and genetic disorders such as Down syndrome. blood disorders and previous treatment for cancer with chemotherapy or radiation are the most common risk factors associated with the onset of the disease.

Leukemia can be classified into acute and chronic leukemia. In acute and chronic leukemia, the abnormal cells can multiply quickly. On the other hand, chronic leukemia, progresses slowly and early symptoms may be very mild.

According to the statistic provided by the Leukemia and Lymphoma Society of Canada, in Canada, leukemia is the most common form of cancer in children 0-14 years of age and the 6th most common among young adults 15 to 29 years.


Every year over 900 children, 0-14 years of age are diagnosed with cancer, accounting for 11% of all childhood cancer.


The most common symptoms of leukemia include persistent fever or chills, fatigue, weakness, frequent or severe infections, unintentional weight loss, swollen lymph nodes, and enlarged liver or spleen.


If you are experiencing some of the above symptoms, please check with your doctor to rule out the possibility of leukemia.


Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region.

The tree has been used in herbal medicine for thousands of years as an aphrodisiac herb and is considered a Queen herb in treating menstrual problems and discomforts by taking it for a prolonged period of time.

There was a report suggested that chaste tree berry stems and leaves can be used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria,

Chemical constituents
1. β-citronellol
2. Labdane-type diterpenoids,
3. Halimane-type diterpenoid,
4. Oleanane-type triterpenoids,
5. Ursane-type triterpenoids,
6. Sesquiterpenoid,
7. Flavonoid
8. Viteagnusins C, D, E, F, G, and H
9. Abietane-type diterpenoids

In the study to reaffirm the extract from the ripe fruit of Vitex Angus-cactus (Vitex), may be considered an anticancer candidate, researchers at the joint investigation led by the Tokyo University of Pharmacy and Life Sciences conducted a study to provide a molecular rationale for clinical development in anticancer therapy(SB203580, an inhibitor for p38 MAPK), a detailed mechanism underlying the efficacy of Vitex against HL-60 cells.

* Vitex and the addition of SB203580 induced a dose- and time-dependent decreased cancer cell viability associated with induction of apoptosis and G(2)/M cell cycle arrest.


* SB203580 significantly suppressed Vitex-induced phosphorylation of histone H3, a downstream molecule of p38 MAPK involved in the induction of tumor cells.

* Vitex inhibited HL-60 cancer cells through, the mediation of cytotoxicity.

* A decline in ROS levels along with enhanced apoptosis was observed after treatment with Vitex.


These results suggested that chaste tree berry inhibited the HL 60 cells by increasing the expression of ROS in the facilitated cytotoxicity and inducing apoptosis through cell cycle arrest.

In the summary of the findings, Dr. Kikuchi H, the lead author said, "These results may have important implications for appropriate clinical uses of Vitex and provide novel insights into the interaction between Vitex and other conventional drugs capable of affecting intracellular redox status".



Further differentiation of the cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin against the leukemia cell lines, HL-60 and U-937, researchers found that Vitex and casticin induced cytotoxicity on both cell lines in a dose depended on manner. and HL-60 cells were more sensitive to the cytotoxicity of Vitex/casticin compared to U-937 cells.


Since the HL-60 cell line is more immature than the U-937 cell line, these results suggested that the levels of cytotoxicity of Vitex/casticin were largely attributed to the types of leukemia cells.


Taken altogether, Chaste tree berry may be considered a functional food and an adjunct therapy combined with conventional medicine for the treatment of leukemia without inducing any side effects.

However, due to the limitation of the studies, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of chaste tree berry anti-leukemia possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract by chi H1, Yuan B1, Yuhara E1, Imai M1, Furutani R1, Fukushima S1, Hazama S1, Hirobe C2, Ohyama K1, Takagi N3, Toyoda H1.(PubMed)
(2) Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines by chi H1, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H.(PubMed)

Healthy Food Broccoli Improves the Chemotherapeutic Drug Efficacy for the Treatment of Head and Neck Cancer

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth that starts in the tissue of specific organs.

Over time, after penetrating into deeper layers of the affected organs, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Head and neck cancer is a class of cancer including the mouth, nose, throat, larynx, sinuses, or salivary glands.

The most common head and neck cancer metastases are secondary skin cancer.

Most cases of head and neck cancer start in the cell of the inner lining of the affected tissue. However, at the later stage, the cancer cell can travel a distance away from the original site to infect other healthy tissues and organs, leading to secondary metastasis.

The exact causes of head and neck cancer are unknown. However, certain risk factors have been found to associate with the onset of the disease, including, excessive alcohol intake, smoking, infection by the HPV virus, poor oral health, race, and long-term exposure to wood dust.

Some researchers suggested that people who perform oral sex before sexual intercourse is at a higher incidence of disease development as human papillomavirus (HPV) can spread during oral sex, increasing the possibility of oral cancer.

Other risk factors such as prolonged sun exposure, infection by Epstein-Barr virus (EBV), poor oral and dental hygiene and occupational inhalants, long-term marijuana, tobacco use, and involuntary smoking are also associated with the onset of head and neck cancer.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential whole for the prevention and treatment of cancer, researchers examined the effect of sulforaphane (SFN) isolated from broccoli extract in the improvement of chemotherapeutic drug efficacy in the treatment of head and neck cancer.

According to the results of differentiation, SF improved the chemotherapeutic efficacies used in the combination with much lower doses of CIS or 5-FU against SCCHN cells, by reducing cytotoxicity to normal cells.

On SCCHN human cell lines (SCC12 and SCC38), titrations of SF standalone or in combination with CIS and 5-FU

* SF treatment alone reduced the SCCHN cell viability in a time- and dose-dependent manner.

* SF-combined treatment not only increased the cytotoxic activity of CIS by two folds and of 5-FU by tenfold against SCCHN but also inhibited SCCHN cell clonogenicity and post-treatment DNA repair with no effect on normal cells. 

Furthermore, SF increased SCCHN apoptosis by promoting the proteins associated with proapoptosis and inhibiting the proteins involved in the anti-apoptotic activity in the tested cell lines.

Based on the findings, researchers said, "Combining SF with low doses of CIS or 5-FU increased cytotoxicity against SCCHN cells while having minimal effects on normal cells".

Taken altogether, broccoli processed with high amounts of sulforaphane may be considered a functional food for reducing chemo drug side effects, pending the confirmation of the larger sample size and multicenter human study.

Intake of sulforaphane in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli extract improves chemotherapeutic drug efficacy against head-neck squamous cell carcinomas by Elkashty OA1,2, Ashry R2, Elghanam GA1,3, Pham HM1, Su X1,4, Stegen C5,6, Tran SD. (PubMed)

Phytochemical Beta-Sitosterol Inhibits the Symptoms of Benign prostatic hyperplasia (BPH)

By Kyle J. Norton

The prostate warped around the urethra is a gland of the male reproductive system found in front of the rectum and just below the bladder responsible for making some of the semen that carries sperm.

The muscle of the prostate gland also plays a critical in nourishing and protecting sperm by secreting fluid in perm ejaculation into the urethra.

Benign prostatic hyperplasia(BPH) is a condition that increases numbers of the cell of prostate tissues, causing partial, or sometimes virtually complete obstruction of the urinary tract.

According to statistics, BPH commonly starts at the age of 30 and symptoms usually can not be realized until the age of 50.

More than half of men between the age of 60-70 experience symptoms of BPH and only 10% is required treatment.

Most symptoms of an enlarged prostate are related to bladder function in urinary excretion.  If you experience some of the symptoms of a weak stream of urine, difficulty starting urination, dribbling of urine, especially after urinating,..... and a sense of not fully emptying the bladder, you may develop enlarge prostate.

In severe cases, patients may also develop symptoms of night time frequent urination and a strong and sudden desire to urinate,.... and blood in the urine.

As the size of the prostate increase, the sex organ pressed on the urethra not only causes urinary problems but also induce urinary pain (dysuria or pain with urination).

Beta-Sitosterol is a phytochemical in the class of phytosterols, belonging to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the protection of the prostate gland, researchers examined the effects of Azuprostat, a beta-sitosterol, in patients with symptoms of outlet obstruction caused by benign prostatic hyperplasia (BPH).

The randomized, double-blind and placebo-controlled clinical trial was conducted to assess the efficacy and safety of 130 mg free beta-sitosterol (phytosterol) daily, using the international prostate symptom score (IPSS) as the primary outcome variable in a total of 177 patients with BPH who were recruited for 6 months treatment in 13 study centers.

Treatment of beta-sitosterol showed a significant improvement of BPH symptoms over placebo.

The mean difference in the IPSS between placebo and beta-sitosterol, adjusted for the initial values, was 5.4 and the quality-of-life index was 0.9.

According to the secondary outcome variables, beta-sitosterol showed an increase in Qmax (4.5 mL/s) and a decrease in PVR (33.5 mL) after adjusting to the changes compared to the placebo.

Based on the findings, researchers said, "These results show that a beta-sitosterol is an effective option in the treatment of BPH".

Taken altogether, beta-Sitosterol may be considered a functional supplement for the prevention and treatment of benign prostatic hyperplasia (BPH), pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol(phytosterol) for the treatment of benign prostatic hyperplasia. German BPH-Phyto Study group by Klippel KF1, Hiltl DM, Schipp B. (PubMed)
(2) Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation by Goluch-Koniuszy Z, Rygielska M, Nowacka I.(PubMed)