Beta-Sitosterol Processes Hypolipidemic Activity

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

High blood cholesterol is the most common cause of hyperlipidemia. According to statistics provided by the CDC, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million American and the condition is increasing at an alarming rate due to overweight and obesity.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

People with hyperlipidemia are asymptomatic. However, if untreated, the condition can cause cholesterol build-up on the arterial wall, leading to narrowing the arteries inducing blockage that causes heart disease and stroke.

The most common inherited form of high blood cholesterol is called familial hypercholesterolemia found in 1/500 people.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention of diseases involved in high blood cholesterol, researchers investigated β-sitosterol ester with linoleic acids and β-sitosterol self-microemulsions preparation on hyperlipidemia mice.

Selected mice were randomly divided into normal group and model group, fed with a basic diet and high-fat diet for 70 days respectively. 

After high-fat model mice were successfully established, the model group was further divided into eight groups: HFD (high-fat diet feeding), SELA-TSO(8 ml/kg, SELA:700 mg/kg), TSO (8 ml/kg), SSSM (8 ml/kg,SS:700 mg/kg), NLSM (8 ml/kg), SSHT-TSO (8 ml/kg, SS: 700 mg/kg) and SS-TSO (8 ml/kg, SS: 700 mg/kg) groups, and treated with β-sitosterol ester with linoleic acid, β-sitosterol self-microemulsion, commercial β-sitosterol health tablets, and β-sitosterol powder for 35 days, respectively.

Based on the results of the experiment,

* β-sitosterol self-microemulsion has the highest anti-hyperlipidemic effect among the experimental groups, compared to β-sitosterol ester with linoleic acids.

* The anti-hyperlipidemic effects are listed as SSSM> SELA-TSO > SSHT-TSO > SS-TSO.

Collectively, researchers said, "a new formulation of β-sitosterol was developed, and its hypolipidemic effect was investigated. The results showed that β-sitosterol self-microemulsion has a good blood lipid-lowering effect".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of β-sitosterol self-microemulsion and β-sitosterol ester with linoleic acid on lipid-lowering in hyperlipidemic mice by Yuan C1, Zhang X1, Long X1, Jin J1, Jin R. (PubMed)