Herbal Chickweed Methanolic Extract, Maybe An Anti Obesity Supplement, Scientists Suggest

By Kyle J. Norton

Adding one or two portions of chickweed into the daily diet may have a positive and profound effect in inducing weight loss, particularly, in overweight and obese patients, some studies suggested.

Obesity is a medical condition of extreme overweight. The disease is an epidemic in the United States. According to the statistic, over 68% of the US population are overweight and half of these overweight people are obese.

According to epidemiological studies, patients with obesity are at a higher risk for serious diseases, such as type 2 diabetes, heart disease, and cancer.

According to Body Mass Index (BMI), the range of overweight is between 25 and 29.9. If your BMI is 30 or over you are considered obese.

The exact causes of obesity are unknown, however, there is a number of prevalent risk factors that cause the early onset of the condition including consuming too many calories than the body needs, a sedentary lifestyle, not sleeping enough, too much stress that leads to endocrine disruption and medication that cause patients to put on weight.

Genetic mutation inherited from the parents also is one of the major causes of obesity.

Dr. Hélène Choquet, the lead author in the study "Genetics of Obesity: What have we Learned?" In 2001, six genes were linked to monogenic human obesity and no common variants were reproducibly associated with polygenic obesity. By 2008, progress in the field led to the discovery of eight monogenic genes and four polygenic genes (FTO, PCSK1, MC4R, CTNNBL1) from associated studies at the genome-wide level of significance".

In the management of overweight and obese patients, researchers at the Park Nicollet Bariatric Surgery Center suggested, "lifestyle modifications should be recommended for every patient dealing with overweight or obesity" and " No single diet has proven to be superior to others overall in terms of weight loss outcomes. However, a low-carbohydrate (ie, ketogenic) diet has been shown to reduce insulin resistance in patients with diabetes and may be considered for this subgroup of patients".

" Exercise alone has not been shown to produce substantial weight loss, but it is helpful during the weight loss phase to preserve lean muscle mass, and it has a role in weight maintenance. Though sleep deprivation has been implicated in weight gain, the effect of improving sleep quality/duration on reducing excess weight has yet to be studied adequately".


These results indicated, actively engaging in low calory diet without causing nutrient deficiency and physical exercise on a long-term basis, and reducing stress levels may be considered good management for overweight and obese patients to lose weight.


Chickweed is a cool-season annual plant in the genus S. media, belonging to the family Caryophyllaceae, native to Europe.

The herb has been used in herbal medicine as astringent, carminative, demulcent, diuretic, expectorant, laxative, refrigerant, and to treat skin conditions, indigestion, eczema, cough, rashes,...

In the finding of a natural ingredient without a side effect in replacement of conventional medicine and surgery in obese patients researchers at the CMR College of Pharmacy, Medchal conducted an evaluation of the effect of chickweed (S. media (MESM)) on food consumption patterns, change in body weight, thermogenesis, lipid metabolism, and histology of fat pad, using progesterone-induced obesity model in female albino mice.

Methanolic and alcoholic extracts of the S. media were used in the experiment. At the final assessment, researchers suggested, the application of a methanolic extract of S. media (MESM) demonstrates a significant effect in preventing the increase in body weight, adipose tissue weight and size, and upturned obesity and associated complications, compared to the alcoholic extract.


Further analysis also discovered, the antiobesity activity produced by MESM is attributed to the anorexic property mediated by saponin and flavonoid and partly by its β-sitosterol content.

Moreover, β-sitosterol, a plant sterol having structural similarity with dietary fat isolated from the methanolic extract of S. media shows a physical competition in the gastrointestinal tract against fat absorption.

Other chemical compounds found in the methanolic extract such as saponin, flavonoids, steroids and triterpenoids, glycosides, and anthocyanidins are also found in aiding the results of weight reduction.

Additionally, the examining of numerous trials conducted by some institutes with an aim to find and develop new anti-obesity drugs through herbal sources with minimizing side effects compared to anti-obesity drugs, researchers at the University of Science and Technology launched an evaluation of the quality control parameters, quantitative phytochemical analysis (total phenolic, total flavonoids, and total saponin content), and the anti-obesity effect of lyophilized juice (LJ) of Stellaria media (Linn.) Vill. in vitro and in vivo models.

The anti-obesity effect of LJ was assessed at two doses, 400 mg/kg and 900 mg/kg body weight in mice fed a high-fat diet with or without LJ for 6 weeks.

Application of both doses in tested mice inhibited pancreatic amylase and lipase activity and elevated plasma triacylglycerol level.


At the dose of 900 mg/kg body weight of the mice fed with a high-fat diet, LJ suppressed the increase in body weight, retroperitoneal adipose tissue, liver weights, and serum parameters viz., total cholesterol, total triglyceride, LDL-cholesterol level

Dr. Rani N, the lead author of the final report, wrote, "The anti-obesity effects of LJ in high-fat-diet-fed mice may be partly mediated through delaying the intestinal absorption of dietary fat and carbohydrate by inhibiting digestive enzymes".


The findings suggested that chickweed methanolic extract may be considered an adjunct therapy in preventing weight gain in overweight and obese subjects.

Intake of methanolic extract of chickweed (S. media (MESM)) should be taken with extreme care, as acute liver toxicity has been reported in a number of cases.

However, further data collection on large example size and multi-centers studies performed with human consumption of chickweed during the course of the disease will be necessary to complete the picture of the wholefood anti-obesity possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1)Antiobesity effect of Stellaria media against drug induced obesity in Swiss albino mice by Chidrawar VR1, Patel KN, Sheth NR, Shiromwar SS, Trivedi P.(PubMed)
(2) Quality assessment and anti-obesity activity of Stellaria media (Linn.) Vill by Rani N1, Vasudeva N, Sharma SK. (PubMed)
(3) Genetics of Obesity: What have we Learned? by Hélène Choquet1 and David Meyre. (PMC)
(4) Obesity: dietary and lifestyle management by Vesely JM1, DeMattia LG. (PubMed)

Tocopherols Inhibits the Onset of Liver Cancer in Vitro

By Kyle J. Norton


The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage of injury.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells' DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to the overexpression of the overweight and obese population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

There is a number of risk factors other than those mentioned above associated with the onset of liver cancer such as male, ethnicity, hepatitis viral carriers.

However, most people with some of the above risk factors have never developed liver cancer.

According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.

In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.

Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31%, and 43% of people with liver cancer are diagnosed at stages 0 and 1.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the prevention and treatment of cancers, researchers examined the effect of poly(lactide-co-glycolide)/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles to accomplish the simultaneous delivery of an optimized ratio of doxorubicin (DOX) and elacridar (ELC) to target both LCSCs and liver cancer cells.

According to the analysis, in vitro
* DOX/ELC molar ratio of 1:1 works synergistically to exhibit significantly increased cytotoxic effects against both HepG2 and HepG2-TS
* DOX/ELC showed a stronger anti-cancer activity, compared with DOX-loaded nanoparticles (NDs) or ELC-loaded nanoparticles (NEs).

* Furthermore, the nanoparticles exhibited better tumor targeting, with NDE showing the strongest antitumor activity with lower systemic toxicity.

Based on the findings, researchers said, "These results suggested that NDE represented a promising combination therapy against liver cancer by targeting both liver cancer cells and CSCs".

Taken altogether, tocopherols may be considered a supplement for reducing the risk of liver cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Codelivery of doxorubicin and elacridar to target both liver cancer cells and stem cells by polylactide-co-glycolide/d-alpha-tocopherol polyethylene glycol 1000 succinate nanoparticles by Chen D1,2,3, Pan X4, Xie F5, Lu Y2, Zou H2, Yin C6, Zhang Y7, Gao J. (PubMed)

Beta-Sitosterol, the Potential Treatment of Atopic Dermatitis

By Kyle J. Norton

Skin, a large organ that forms the out layers of our body has serval layers of ectodermal tissue to protect the underlying muscles, bones, ligaments, and internal organs against foreign pathogenic invasion.

Dermatitis or eczema is a group of diseases characterized by the inflammation of the skin.

There is no single cause of eczema, anything that we face every day can trigger a dermatitis flare, including stress, irritants, climate change, and sweating. However, infection and allergens. are considered the most common causes of the disease.

Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.

Most cases of atopic dermatitis are found in children. However, adults may also get it too.

The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environmental conditions may involve in the development of the disease.

Epidemiological studies suggested that most patients with chronic atopic dermatitis also have asthma and hay fever, particularly allergies.

Atopic dermatitis has been found to associate with exposure to allergens such as pollen, pet dander, or peanuts, or by stress, dry skin, and infection.

Some atopic dermatitis may also be triggered by skin irritants such as some fabrics, soaps, and household cleaners.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of skin diseases, researchers examined the effect of β-sitosterol (BS) on atopic dermatitis (AD).

In NC/Nga mice induced AD-like skin lesions in NC/Nga by 2,4-dinitrofluorobenzene (DNFB), BS reduced the total clinical severity of AD.

The application of BS inhibited the Infiltration of inflammatory cells and the number of scratching, compared to the DNFB-treated group.

In other words, BS significantly reduced the levels of inflammation-related mRNA and protein and tumor necrosis factor-α from the stimulated splenocytes in the AD skin lesions.

Furthermore, BS significantly also reduced the levels of histamine, IgE, and interleukin-4 associated with skin inflammation n the serum of DNFB-treated NC/Nga mice

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of atopic dermatitis, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP by Han NR1, Kim HM, Jeong HJ. (PubMed)

Phytochemical Betacyanins Isolated From Beetroots May Process Anti Prostate Cancer Potency

By Kyle J. Norton

The prostate gland is a male reproductive organ warped around the urethra located in front of the rectum and just below the bladder responsible for making some of the semen that carries sperm.

The muscle of the prostate gland also plays a critical in nourishing and protecting sperm by secreting fluid in perm ejaculation into the urethra.

Prostate cancer is a medical and chronic condition characterized by abnormal cell growth in the tissues of the prostate.


Most cases of prostate cancer start in the cells on the surface of the inner lining tissue of the prostate, before penetrating into the deeper layers to colonize the entire prostate through cell proliferation.

At the advanced stage, prostate cancer also can spread to distant parts of the body. Most prostate cancers are slow-growing. Enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.

According to the statistics provided by the Canadian Cancer Society, in Canada, 1 in 7 men will develop prostate cancer during their lifetime, and the mortality rate of men is 1 in 27.

In other words, 1 in 4 men diagnosed with prostate cancer will die because of the disease.

The exact causes of prostate cancer are unknown, Epidemiologically, researchers do know that the below are some factors that increase the prevalence of the diseases
* Age
The risk of developing prostate cancer increases with the age of over 45

* Family history
If one of your directed family members has prostate cancer, you are twice at risk to develop it.

* Race
Prostate cancer is more likely to strike black and white in the US.

* Heredity
Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in the pathology of prostate cancer.

* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk to develop prostate cancer.

* Excessive drinking
Excessive drink not only increases the risk of liver cancer but is also associated with a higher risk of prostate cancer as it interferes with folate metabolism.

* Enlarged prostate
Men with an enlarged prostate are at high risk in developing prostate cancer.

* Sexual transmitting diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of the diseases.

* Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.

However, most people with some of the risk factors have never had developed prostate cancer

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.


On finding a potential compound for the treatment of prostate cancer, researchers examined the effect of the red beetroot extract (Beta vulgaris L.), the FDA-approved red food color E162 on the development of multi-organ tumors in experimental animals.

In human androgen-independent, human prostate cancer cells (PC-3) researchers compared the cytotoxic effect of the red beetroot extract with an anticancer drug, doxorubicin (adriamycin),
* Both doxorubicin and the beetroot extract exhibited a dose-dependent cytotoxic effect in the PC3 cancer cell lines.

* Further analysis of the cytotoxic activity of beetroot extract, researchers found that although the cytotoxicity of the beetroot extract was significantly lower compared to doxorubicin, it continued to decrease the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) at the concentration of 29 µg/ml compared to those of doxorubicin which completely inhibited the growth of the PC-3 cells in three days at the same concentration level.


* According to the chemical differentiation, the efficacy of beetroot extract anti-prostate cancer activity was attributed to the major betacyanin constituent, that plays an important role in the cytotoxic exhibition.
In other words, all phytochemicals work synergistically to exert anti-prostate cancer properties, particularly, betanin, the major ingredient of betacyanin.

Taken altogether, betacyanins used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(2) Prostate Cancer by Kyle J. Norton

Healthy Food Turmeric Inhibits the Brain Cell Damage Against the Onset of Memory Deficits

By Kyle J. Norton

Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.

Memory loss frequently is an early sign of memory deficit. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.

Some memory changes can be resolved on their own or cured by medical treatment if the underlining cause is found. However, loss or gradual loss of neurons capacity cannot be revered such as dementia.

According to statistics, in the US, approximately 5.7 million people are living with dementia. The most common form of dementia is Alzheimer's disease, affecting 5.5 million people of all ages.


The most common risk factor associated with memory deficit is increasing age, smoking the genetic preposition of APOE-e4, also linked to Alzheimer's disease, obesity, and medical conditions such as diabetes, high blood pressure and depression, and physical inactivity.

Out of many risk factors, aging may be one of the major culprits that cause memory deficit in large numbers of older adults, leading to irreversible memory impairment such as AD and PD.

Dr. Gary W Small, said, "Memory changes cause concern to many patients as they grow older.". However, there are some factors that can decrease the progression of the condition, including stress reduction, physical and mental activity, a healthy diet, and lifestyle choices.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound that processes anti-neuro-degeneration, researchers examined the effects of curcumin on the early stage amnesia of AD related to memory retrieval deficit.


Selected Male NMRI mice (20-25 g body weight) included in the study were treated with 50 or 100 mg/kg/po curcumin or its vehicle for 10 days. During the experiment, the animals were trained in passive avoidance apparatus ar days 10 and 30 min. before the retention test that performs after 24 hours of curcumin or its vehicle application, scopolamine (1 mg/kg/i.p.) or its vehicle was administrated.

According to the tested analysis, curcumin treatment at 50 and 100 mg/kg doses not only inhibited the activity of scopolamine in the induction of memory retrieval deficit but also restored Akt and GSK dephosphorylation associated with neuroprotection against scopolamine.


In other words, curcumin at the tested concentration effectively protect the Akt and GSK pathways which play are a critical role in enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis caused by scopolamine in the brain.

After taking others into account, Dr. Lv KJ, wrote in the final report, "pre-test scopolamine administration disrupts memory retrieval along with with with with the diminished Akt and GSK-3β phosphorylation in the hippocampus while curcumin administration prevented those changes."

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of memory retrieval deficit, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats by Yuliani S1, Mustofa2, Partadiredja G. (PubMed)
(2) Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3β by SoukhakLari R1, Moezi L2, Pirsalami F3, Ashjazadeh N4, Moosavi M. (PubMed)
(3) What we need to know about age related memory loss by Gary W Small, Parlow-Solomon professor on aging. (PMC)

Pungent Spice Onion May Process Anti Asthmatic Property

By Kyle J. Norton

Respiratory disease is a class of medical conditions that affect the breathing organ and tissues. The most common respiratory diseases are inflammatory lung disease, obstructive lung diseases, restrictive lung diseases, and respiratory tract infections.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

The medical condition affects people of all ages, and mostly starts during childhood.

In the US, approximately, 25 million people are living with asthma, including 7 million children.


The most common risk factors associated with the onset of asthma, according to epidemiological studies are
* Wheezing rhinovirus illnesses
Virus-induced wheezing episodes in infancy often precede the development of asthma.

*Airflow obstruction
Asthma and family history of allergic rhinitis are important risk factors associated with airflow. according to the Department of Pediatrics, Lerdsin General Hospitalobstruction.

* Gender
If you are a woman, you are at increased risk to develop asthma. Asthma, after childhood, is more severe in females than in males and is under-diagnosed and under-treated in female adolescents.

* Stress
Stress, whether at the individual (i.e. epigenetics, perceived stress), family (i.e. prenatal maternal stress, early-life exposure, or intimate partner violence), or community (i.e. neighborhood violence; neighborhood disadvantage) level, influence asthma and asthma morbidity.

* Genes
GSTP1, INSIG2, and IL4Ra may influence lifetime asthma susceptibility through gene-gene interactions in schoolchildren.

* Airway inflammation and hyperreactivity
People with airway hyperreactivity are at increased risk to develop asthma as a result of the immune system over-response to allergens.

5. Atopy and viral infection
Atopy – such as eczema, allergic rhinitis, allergic conjunctivitis, and viral infection are associated with a higher risk of asthma development.

* Family history
Family history of asthma in one or more first-degree relatives was consistently identified as a risk factor for asthma.

* Smoke during Pregnancy
Smoking and severe asthma exacerbations in pregnancy are risk factors for low birth weight babies.
During pregnancy, asthma exacerbations are more common and more severe in current smokers than never smokers. The risk of the effects of maternal asthma on the fetus may be greater among smokers.

* Low birth weight
In the 1988 national birth cohort, an estimated 4000 excess asthma cases were attributable to birth weight less than 2500 g.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and is found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of asthma researchers investigated the effect of Allium cepa L. extract (AcE) and its quercetin (Qt) on cytokine and on smooth muscle contraction associated with asthma in vitro and Vivo.

According to the tested analysis, * In vitro, AcE 10, 100 or 1000 μg/ml or Qt 35, 7.5, 15 μg/ml, showed a significant effect in inhibition of the production of pro-inflammatory cytokines.

* With the same concentrations, AcE also expressed the ability to relax tracheal smooth muscle from A/J mice.

* Furthermore, with the concentrations of 100, 1000 mg/kg or 30 mg/kg Qt in Blomia tropicalis (BT)-sensitized A/J mice treated, AcE also decreased the total number of cells of bronchoalveolar lavage (BAL), and eosinophil peroxidase (EPO) in lungs, the markers found in patients with asthma.

Based on the results, researchers wrote, "AcE and Qt have potential as antiasthmatic drugs, as they possess both immunomodulatory and bronchodilatory properties".

Taken altogether, onion may be considered a remedy for the prevention and treatment of asthma, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma by Oliveira TT1, Campos KM2, Cerqueira-Lima AT3, Cana Brasil Carneiro T4, da Silva Velozo E5, Ribeiro Melo IC6, Figueiredo EA7, de Jesus Oliveira E8, de Vasconcelos DF9, Pontes-de-Carvalho LC10, Alcântara-Neves NM11, Figueiredo CA. (PubMed)
(2) Onions, myths, beliefs, fashion and reality in asthma by Martínez-Gimeno A. (PubMed)
(3)
Asthma (Respiratory Disease) – The Risk factors by Kyle J. Norton

Phytochemical Tocopherols Prevent the Risk of Type 2 Diabetes Induced by Oxidative Stress

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to statistics, diabetes is one of the most common diseases in the US. Approximately 10% or 29.1 million people in the United States have diabetes, accompanied by 8.1 million that are undiagnosed and unaware of their condition.

About 1.4 million new cases of diabetes are diagnosed in the United States every year. More than one in every 10 adults who are 20 years or older has diabetes.

The most common forms of Diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form of diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutations and viruses.

* Type 2 diabetes, the most common form of acquired diabetes in adulthood is a chronic condition that affects the body's metabolized glucose. In other words, most cases of type 2 diabetes are the result of insulin receptors clogged up by fat and cholesterol, leading to resisting the effects of the hormone insulin that regulates the movement of sugar into your cells.

* Gestational diabetes is a form of diabetes that can occur during pregnancy, affecting between 3% and 20% of pregnant women.

Women with gestational diabetes are at an increased risk of type 2 diabetes in later life.

Oxidative stress is a condition characterized by the imbalance of the ratio of free radicals and antioxidant enzymes.

type 2 

In some cases, oxidative stress can also be caused by the long-term accumulation of toxic substances in the body, such as lead, cadmium, mercury, and arsenic.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of diabetes, researchers examined the effect of α-tocopherol on bone marrow mesenchymal cells derived (BMMCs) from type II diabetes mellitus rats.

According to the experimental results of BMMCs either untreated or exposed to α-tocopherol at concentrations of 1.0, 10, and 100 μM, at the concentration of 100 μM, α-tocopherol showed no effect on cell proliferation, but the significantly increased H2O2 activity against the tested cells.

At 10 μM, α-tocopherol increased the gene expression of pro-inflammatory cytokines such as IL-1β and TNF-α.

Furthermore, the concentration of 100 μM α-tocopherol exerted a lower expression of free radical catalase compared to the other concentrations.

Based on the findings, researchers said, "At a low concentration, α-tocopherol exerted good antioxidant and anti-inflammatory effects on BMMCs" and

"Maintaining α-tocopherol at a low concentration might promote the recovery of BMMCs from oxidative stress".

Taken altogether, tocopherols may be considered a functional food for the prevention and treatment of type 2 diabetes induced by oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of α-tocopherol on bone marrow mesenchymal cells derived from type II diabetes mellitus rats by Noguchi M1, Yamawaki I1, Takahashi S1, Taguchi Y1, Umeda M. (PubMed)