Beta-Sitosterol Blocks the Onset of Lung Inflammation

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.

Respiratory disease is a medical condition that affects the breathing organ and tissues including Inflammatory lung disease, such as obstructive lung diseases, restrictive lung diseases, respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves,....... and muscles breathing.

Asthma is a chronic inflammatory disease, affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

The disease affects people of all ages, and mostly starts during childhood.

According to the American academy, allergy, asthma, and immunology, about 1 in 10 children (10%) had asthma and 1 in 12 adults (8%) had asthma in 2009. (about 25 million, or 8% of the U.S. population).

Inflammation is the natural response of the immune system macrophages, the first line of defense in stimulating the production of inflammatory cytokines to protect our body against the infection caused by foreign microorganisms during the acute phase of body damage and injury.

Truly, the main focus of inflammation is to repair damage and injury.

Most cases of infection associated with inflammation are stopped at the acute phase. The wound or injury is slowly recovered.

However, overexpression of inflammatory cytokines in most cases can cause improper healing with scar formation or the death of nearby cells.

Any inflammation that lasts more than 3 months is considered chronic inflammation.

Chronic inflammation is the result of the immune system's inability to kill off all the microorganisms that participated in the acute phase of infection, leading to the forming of autoimmune and chronic inflammatory diseases such as RA and diabetes.

However, in people with a weakened immune system, acute inflammatory progression cannot be stopped due to the inability of the immune system to destroy all invaders, which may lead to low-grade chronic inflammation.

Epidemiologically, diseases associated with chronic inflammation are asthma, chronic peptic ulcer, tuberculosis, rheumatoid arthritis, periodontitis, inflammatory bowel inflammatory disease (ulcerative colitis and Crohn's disease), sinusitis, and hepatitis.

Anti-inflammation is the process that inhibits inflammation or swelling without affecting the immune property to curb foreign pathogens.

Conventionally, the most common use of anti-inflammatory medicines is over counter aspirin, ibuprofen (Advil, Motrin, Nuprin), and other prescription NSAIDs.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of chronic inflammatory diseases, researchers examined the inhibitory effects of beta-sitosterol (BS) and lactose-BS (L-BS) on the pathophysiological process in ovalbumin-induced asthmatic mice.

According to the chemical analysis, beta-sitosterol (BS) and lactose-BS (L-BS) showed a significant activity to decrease the total cells and eosinophils in the bronchoalveolar lavage (BAL) fluid and the ROS production compared to the asthma control. 

In other words, beta-sitosterol (BS) and lactose-BS (L-BS) inhibited the expression of immune response that induces inflammation through their anti-inflammatory expression.
More precisely, both L-BS and BS mitigated the inflammation by eosinophil infiltration and mucus hypersecretion by goblet hyperplasia.

Furthermore, L-BS and BS inhibited the increased mRNA and protein expression of IL-4 and IL-5, the pro-inflammatory proteins in the lung tissue and BAL fluid, respectively.

In comparison essays, L-BS were superior to those of BS, including the inhibition of Ovalbumin-specific IgE in the BAL fluid.

Moreover, L-BS blocked the survival rate of the splenocytes of the mice compared to the BS group and control.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of lung inflammation, particularly in patients with asthma, pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models by Gómez MA1, Sáenz MT, García MD, Fernández MA. (PubMed)

lung Inflammation
(1) Effects of lactose-beta-sitosterol and beta-sitosterol on ovalbumin-induced lung inflammation in actively sensitized mice by Yuk JE1, Woo JS, Yun CY, Lee JS, Kim JH, Song GY, Yang EJ, Hur IK, Kim IS. (PubMed)

Bilberry, The Herbal Medicine for Reducing Risk and Treatment of Nonalcoholic Fatty Liver Disease (NAFLD), Scientists Say

By Kyle J. Norton

Nonalcoholic fatty liver disease (NAFLD) is a type of noninflammatory fatty liver disease caused by fat accumulated in the liver other than excessive alcohol consumption.

People who have an accumulation of triglycerides within hepatocytes that exceeds 5% of liver weight are considered to have nonalcoholic fatty liver disease.

According to the statistics, nonalcoholic fatty liver disease (NAFLD) has risen rapidly over the past few decades and become the most common cause of chronic liver disease in the developing world. The disease affects between 17-30% of the population in Western countries and 2-4% worldwide.

Epidemiologically. obesity, type II diabetes, dyslipidemia, and insulin resistance are the well-known primary causes of NAFLD.

The findings strongly suggested that NAFLD is a geographically related disease associated with dietary patterns.

Dr. Alanna McCarthy, the lead scientist in the examination of diet patterns in the risk NAFLD wrote, "Non-alcoholic fatty liver disease (NAFLD) is a serious consequence of high-fat diet intake and currently affects approximately one-third of the world’s entire population".

And, "Recent evidence suggests that patients with NAFLD have a higher incidence of cardiovascular disease compared to the general population. However, little is known about the link between NAFLD and pathological cardiac remodeling leading to heart disease".

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find natural prevention and treatment of non-alcoholic fatty liver disease (NAFLD), researchers investigated the effects of anthocyanin supplementation on insulin resistance and liver injury biomarkers in patients.

74 subjects with NAFLD included in the study were divided into 2 groups in this double-blind, randomized study. Patients received either purified anthocyanin (320 mg/d) derived from bilberry and black currant or a placebo for 12 weeks.

During the experiment, the anthocyanin group exhibited significantly decreased in plasma alanine aminotransferase, cytokeratin-18 M30 fragment, and myeloperoxidase, the biomarkers associated with NAFLD, compared to controls.

Compared to the baseline, the anthocyanin group significantly decreased in fasting blood glucose and homeostasis model assessment for insulin resistance, however, these differences were not significant relative to placebo controls.

Not surprisingly, anthocyanin supplementation significantly decreased the 2-hour loading glucose level compared to control, according to the oral glucose tolerance test.

Based on the findings, researchers said, "A 12-week supplement of purified anthocyanin improved insulin resistance, indicators of liver injury, and clinical evolution in NAFLD patients".

Furthermore, according to the results from the study of ApoE(∗)3Leiden mice fed a Western-type cholesterol-containing diet without (HC) or with 0.1% (w/w) Mirtoselect (HCM), an anthocyanin-rich bilberry extract for 20weeks on diet-induced NASH, Mirtoselect treatment group showed an attenuated HC-induced hepatic steatosis and reduced hepatic cholesteryl ester content.

Furthermore, injection of Mirtoselect also exerted local anti-inflammatory effects in the liver by reduced inflammatory cell clusters and neutrophil infiltration in HCM.

In other words, HCM protected the liver against HC diet significantly induced hepatic expression of pro-inflammatory and pro-fibrotic genes associated with the onset of NAFLD.

Dr. Morrison MC, the lead scientist, after taking other factors into account wrote, "Mirtoselect attenuates the development of NASH, reducing hepatic lipid accumulation, inflammation, and fibrosis, possibly mediated by local anti-inflammatory effects associated with reduced accumulation and crystallization of intrahepatic free cholesterol".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of nonalcoholic fatty liver disease, pending the validation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) A CONSORT-compliant, randomized, double-blind, placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease by Zhang PW1, Chen FX, Li D, Ling WH, Guo HH. (PubMed)
(2) Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice by Morrison MC1, Liang W2, Mulder P2, Verschuren L2, Pieterman E2, Toet K2, Heeringa P3, Wielinga PY2, Kooistra T2, Kleemann R. (PubMed)
(3) High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease and Cardiac Physiology in Mice by
Alanna McCarthy and Stephen Luckey. (Faseb Journal)

Navy Bean Reduces the Risk of Colorectal Cancer, Researchers show

By Kyle J. Norton

Colorectum is the digestive organ containing the colon and the rectum.

The colon-formed part of the large intestine plays a critical role in re-absorbing fluids and processing waste products from the body for elimination.

The colon consists of four parts: descending colon, ascending colon, transverse colon, and sigmoid colon

The rectum or the part of the large intestine nearest the rectum plays a temporary storehouse for feces.

Colorectal cancer is a chronic condition characterized by abnormal proliferation of cells in the colon, rectum, or vermiform appendix.

Colorectal cancer is a relatively very common and slowly growing cancer in the US. colorectal cancer has also been found to progress in a predictable way.
The disease is more common in people over the age of 50. Regular colonoscopy after age of 50 is valuable to detect the disease in the early stage, thereby increasing the rate of survival.

According to the statistics provided by the American Cancer Society, colorectal cancer, including cancer in the colon or rectum is the third most commonly diagnosed cancer and the second leading cause of cancer death in men and women combined in the United States.

Approximately, in 100 cases of colorectal cancer, 71% of cases arise in the colon compared to 29% in the rectum.


The most common types of colorectal cancer classified depending on the primary originated cells are
* Adenocarcinomas
Most bowel cancers are adenocarcinomas, originating in epithelium tissues, including the surface layer of skin, glands, and their tissues that line the cavities and organs of the body.

* Squamous cell cancers
Squamous cells are the skin-like cells that make up the bowel lining together with the gland cells. Squamous cell cancers are rare with the risk of 25 per 100000 population.


The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

On finding a potential compound for the prevention and treatment of cancer, researchers examined the effects of consumption of navy beans (NB) and rice bran (RB) on CRC survivors' serum inflammatory biomarkers and telomere lengths.

The study included 29 subjects who completed a randomized controlled trial with foods that included cooked NB powder (35 g/day), heat-stabilized RB (30 g/day), or no additional ingredient.

According to the tested analysis,* NB or RB consumed equated to 4-9% of subjects' daily caloric intake. Increased consumption of NB or RB showed no effects on major gastrointestinal issues.

* Furthermore, NB or RB consumed increased dietary fiber amounts at Weeks 2 and 4 compared to baseline and to control.

* NB or RB consumed also increased the telomere length correlated with age and HDL cholesterol compared to baseline, accompanied by improving serum amyloid A (SAA) levels at Week 4.

Additionally, in CRC chemoprevention, in the study of the effects of eating SRB (30 g/day) or cooked navy bean powder (35 g/day) on gut microbiota and metabolites on colorectal cancer survivors, Dr. the lead scientist found that SRB or NBP showed increased gut bacterial diversity and altered gut microbial composition at 28 days associated with CRC prevention.

Collectively, these results strongly suggested that NB or RB consumption improves the parameters associated with CRC chemoprevention.

Taken altogether, the fermented navy bean may be considered a remedy for the prevention and treatment of colorectal cancer, pending the confirmation of the larger sample size and multicenter human study.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Randomized Controlled Trial to Increase Navy Bean or Rice Bran Consumption in Colorectal Cancer Survivors by Borresen EC1, Brown DG1, Harbison G1, Taylor L1, Fairbanks A1, O'Malia J2, Bazan M2, Rao S3, Bailey SM1, Wdowik M4,5, Weir TL4, Brown RJ6, Ryan EP. (PubMed)
(2) Dietary supplementation with rice bran or navy bean alters gut bacterial metabolism in colorectal cancer survivors by Sheflin AM1, Borresen EC2, Kirkwood JS3, Boot CM4, Whitney AK1, Lu S1, Brown RJ5, Broeckling CD3, Ryan EP2, Weir TL. (PubMed)

The Effects of Omega -3 on Hypercholesterolemia

By Kyle J. Norton


Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.

Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, build strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.

The cause of hypercholesterolemia is a result of overexpression of low-density lipoprotein with reduced levels of high-density lipoprotein in the blood.

Believe it or not, cholesterol produced by the liver or from outside sources is essential for the building of the strong cell membranes, the production of steroid hormone and vitamin D.

Compared to hypercholesterolemia, the healthy levels of LDL/HDL are any numbers that are less than 4.

Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.

The most common complications associated with uncontrolled hypercholesterolemia are carotid artery disease, coronary heart disease, including angina or heart attack, peripheral artery disease, and stroke.

According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor of heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol, and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.

Sadly, only 50% of people hypercholesterolemia are getting treatment.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of diseases associated with hyper-cholesterol, researchers examined the effects of omega-3-acid ethyl esters (POM3, 4 g/day) versus placebo (soy oil) on low-density lipoprotein cholesterol (LDL-C) and other aspects of the fasting lipid profile.

The double-blind, randomized crossover study included 31 men and women with primary, isolated hypercholesterolemia (LDL-C 130-220 mg/dL and triglycerides less than 150 mg/dL while free of lipid-altering therapies).

According to the results of the experiment,
* POM3 produced a modest increase from baseline in LDL-C (3.4%) versus the placebo response (-0.7%, P = 0.010).

* POM3 significant changes (P < 0.05) the levels of very-low-density lipoprotein cholesterol (-18.8%), triglycerides (-18.7%), and HDL-C (3.3%).

* Most importantly, very-low-density lipoprotein particle concentration and size and HDL particle concentration decreased significantly more with POM3 versus placebo, whereas LDL and HDL particle sizes increased significantly more with POM3 versus placebo.

* Total cholesterol, non-HDL-C, apolipoproteins A1 and B, and LDL particle concentration responses did not differ between treatments

Based on the findings, researchers said, " These results did not confirm the hypothesis that POM3 treatment would lower LDL-C in primary, isolated hypercholesterolemia. Effects on other variables were consistent with prior results in mixed dyslipidemia".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of hypercholesterolemia,  pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia by Maki KC1, Lawless AL, Kelley KM, Dicklin MR, Kaden VN, Schild AL, Rains TM, Marshall JW. (PubMed)

Tocopherols, the Potential Anti-Esophageal Cancer Plantbased Phytochemical

By Kyle J. Norton

An esophagus or gullet, an organ in vertebrates, is the tube that leads foods from the pharynx to the stomach.

Esophageal cancer is not very uncommon caused by malignant of the esophagus due to abnormal cell growth as a result of the DNA alternation of the cells that line the upper part of the esophagus or glandular cells that are present at the lower part of the esophagus connected with the stomach.

Esophageal cancer tends to spread if it left untreated and starts from the lining of the esophagus, then later penetrates the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach and the chest, then to the distant parts of the body.

According to the statistics provided by the American Cancer Society, in 2019, approximately 17,650 new esophageal cancer cases will be diagnosed, including 13,750 in men and 3,900 in women.

Also, in 2019, esophageal cancer will also cause the death of 16,080 Americans, including 13,020 in men and 3,060 in women.

The 5-year survival rate of people diagnosed in the local stage of esophageal cancer is 45%, much less than other cancer, including 100% of breast cancer.

The 2 common types of esophageal cancer are

* Adenocarcinomas are the most common type of esophageal cancer in the United States, occurred in the mucus-forming gland cells in the lower part of the esophagus.

* Squamous cancer occurs in the flat, thin cells that line the surface of the upper part of the esophagus.

Tocopherols are phytochemicals of which many have vitamin E activity, belongings to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of cancers, researchers examined the effect of dietary tocopherols on esophageal squamous cell carcinoma (ESCC).

According to the analysis, dietary tocopherols significantly inhibited the onset of esophageal carcinogenesis by inhibiting the activation of protein (NF-κB) in the stimulation of the expression of genes involved in the antiapoptotic activity.

Furthermore, dietary tocopherols also interact with the innate and adaptive immunity to inhibit the ESCC by N-Nitroso-N-methyl benzylamine )NMBA) in murine models.

Moreover, the dietary supplementation with 0.15% α-tocopherol (α-T), δ-tocopherol (δ-T), or γ-tocopherol rich mixture (γ-TmT) markedly suppressed the production of pro-inflammatory cytokines and the levels of induction of CXCR3+ effector T cells (CD4+ Th1 and CD8+ CTLs) infiltration involved in T cell trafficking and function, especially at the early stage of carcinogenesis.

Based on the results, scientists said, " tocopherols decrease carcinogenesis through inhibiting NF-κB and CXCR3 signaling, as well as related inflammation in early premalignant lesions. This pathway may offer a novel target for chemoprevention of esophageal cancer".

Taken altogether, tocopherols may be considered a supplement for the prevention of esophageal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tocopherols inhibit esophageal carcinogenesis through attenuating NF-κB activation and CXCR3-mediated inflammation by Yang H1, Xu M2, Lu F3, Zhang Q4, Feng Y4, Yang CS5, Li N4, Jia X. (PubMed).

Cayenne Pepper in Reducing the Risk of Metabolic Dysregulation

By Kyle J. Norton

Cayenne pepper may be the next herbal medicine in reduced risk and treatment of metabolic dysregulation, a recent study suggested

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum Annuum, the family Solanaceae, native to subtropical and tropical regions. It has been used in traditional medicine to increase metabolism, enhance the circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

Metabolic dysregulation refers to abnormal function of the body in regulation of glucose tolerance, fasting glucose, insulin resistance, dyslipidemia,...., leading to insulin resistance, type 2 diabetes, and fatty liver disease.

Capsaicin, the major chemical compound used in dietary supplements attenuated metabolic dysregulation in genetically obese diabetic mice by enhancing expression of modulation of glucose and lipid metabolism involving its receptors.

In obesity-induced inflammation and the development of obesity-related metabolic disorders, cayenne capsaicin suppressed inflammatory responses in inducing glucose intolerance and enhancing fatty acid oxidation in fat tissues, affecting insulin resistance.

The chemical compound involvement in reduced visceral adipose fat, also lowered serum levels of fasting glucose, total cholesterol, and triglycerides, probably through limited fat accumulation in adipose tissues and reduced inflammation, and increased insulin sensitivity.

Dr. Leung FW. said," Clinical evidence supports the role of capsaicin as an anti-obesity agent. Both oral and gastrointestinal exposure to capsaicin increase satiety and reduce energy and fat intake and reduction in visceral abdominal fat" and "Thermogenesis and lipid metabolism-related proteins are altered upon capsaicin treatment in white adipose tissue".

Intake of cayenne for weight loss treatment-induced reduction in visceral abdominal fat may also improve metabolic regulation. Quality of doses should only be given by specialists to prevent toxicity.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice by Kang JH1, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R.(PubMed)
(2) Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet by Kang JH1, Goto T, Han IS, Kawada T, Kim YM, Yu R.(PubMed)
(3) Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice by Lee GR1, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH, Han IS.(PubMed)

Papaya, a Potential Food for the Treatment of Anemia, Researchers Find

By Kyle J. Norton

Scientists may have found a whole fruit for the treatment of anemia with no side effects, according to studies.

Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.

Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout your body.

There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, an ulcer, cancer, and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.

People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.

Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. the Duliajan College study suggested that certain genes such as the βE-Globin Gene is associated with the onset of anemia.



Dr. SK Sharma, the lead scientists in examine the anemia in the Indian population surprisingly found that there is a high prevalence of anemia among children (78.9%), ever-married women (56.2%), pregnant women (57.9%), and never-married men (24.3%) in India.

The doctor continued after observing the levels of hemoglobin in the tested subjects, " Association of the lower level of hemoglobin,...., was observed in subjects carrying the βE-globin gene. The mean (± SD) hemoglobin levels of the subject with heterozygous and homozygous state of HbE was 10.9 ± 0.95 and 9.7 ± 0.64 g/dL, respectively, against 11.28 ± 1.42 g/dL observed in normal hemoglobin pattern (Hb AA)".

These results clearly stated that amenia may be a genetic preposition-related disease that can be reversed in some people.


Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries.

With an aim to find a natural ingredient or whole food for the treatment of anemia, with no side effect, researchers at the Covenant University, examined the papaya anti-anemia effect in subjects with sickle cell disease (SCD)

Sickle cell disease (SCD)is a genetic disease caused by an individual inheriting an allele for sickle cell hemoglobin from both parents. The disease is associated with the unusual production of a large number of immature blood cells.

Application of Carica papaya seed oil (Cari-oil) showed significant effects in reducing the levels of sickle blood cells compared with that of untreated SCD patients.


RBCs in Cari-oil treated samples were significantly higher (P < 0.05) compared with VerMyg, antisickling plant-treated samples.

The Cari-oil extract significantly reduced (P < 0.05) lactate dehydrogenase activity, in both in male (HbSSM) and female (HbSSF) human sickle cell blood.

Lactate dehydrogenase activity, LDH consistently increased in patients with anemia.
Furthermore, Cari-oil treated HbSSM and HbSSF blood had significantly increased (P < 0.05) peroxidase activity which was a significant decrease in patients with anemia, compared with controls.

Dr. the lead scientist suggested at the end of the experiment, "Methanolic extracts from... C. papaya seed oil exhibited antisickling properties coupled with the potential to reduce stress in sickle cell patients".


Moreover, in patients with beta-thalassemia major and intermedia and E-beta-thalassemia, researchers found that by ameliorating oxidative stress in red blood cells, the disease may be treatable.

In vitro and in vivo, oral administration of FPP to beta-thalassemia mice (50 mg/mouse/day for 3 months) and to patients (3 g x 3 times/day for 3 months), reduced all the above-mentioned parameters of oxidative stress (p < 0.001 in mice and p < 0.005 inpatients).

The results suggested that FPP, as a potent antioxidant, might alleviate symptoms associated with oxidative stress in severe forms of thalassemia.

In human studies, injection of fermented papaya preparation (FPP) on two groups of beta-thal patients: beta-thal, major and intermedia, (in Israel) and E-beta-thal (in Singapore) increased the production of antioxidant enzymes produced by the host and significantly decreased the levels of ROS.

In other words, fermented papaya preparation (FPP) increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased their reactive oxygen species (ROS) generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS), indicating amelioration of their oxidative status, without a significant change in the hematological parameters.

The finding in human studies indicated it is possible that a longer duration of treatment, probably with the addition of an iron chelator, is required in order to achieve a significant change in the hematological parameters.

Taken altogether, Papaya, particularly in fermentation, may be considered functional for the prevention and treatment of anemia with no side effects.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Solenostemon monostachyus, Ipomoea involucrata and Carica papayaseed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease by Afolabi IS1, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT. (PubMed)
(2) Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation by Fibach E1, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA. (PubMed)
(3) Fermented papayapreparation as redox regulator in blood cells of beta-thalassemic mice and patients by Amer J1, Goldfarb A, Rachmilewitz EA, Fibach E(PubMed)
(4) Preliminary in vitro antisickilng properties of crude juice extracts of Persia Americana, Citrus sinensis, Carica papaya and Ciklavit® by Iweala EE1, Uhegbu FO, Ogu GN.(PubMed)