#Sulforaphane (SFN) Isolated from Collard Greens Inhibit Pro-Inflammatory Cytokines Associated with Neuropathic Pain, Researchers Reveal

Kyle J. Norton

Neurological disorders are a class of diseases of the nervous system characterized by structural damage, and biochemical or electrical abnormalities in the brain, spinal cord, or nerves.

Neurodegenerative disease is a type of neurological disorder associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Neuropathic pain is a type of pain that affects the somatosensory nervous system due to damage or disease. Abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia) are some of the most common forms of neuropathic pain found in patients.

There are no obvious causes of neuropathic pain. However, medical conditions such as alcoholism, amputation, diabetes, nerve problems, HIV infection or AIDS, multiple myeloma, multiple sclerosis and shingles, and chemotherapy are some prevalent factors of neuropathic pain.

According to the joint study conducted by the Health Outcomes Practice, there are no published data on the broad prevalence of neuropathic pain (NeP) in the US. However, the 15,751 respondents reported pain (63.7%), of 2,548 data suggested that 10% of Americans may suffer from neuropathic pain (NeP). The rate of NeP in Blacks and Hispanics ethnicity was consistently higher compared to White


Most common treatments of NeP are the use of nonsteroidal anti-inflammatory drugs (44.2%), followed by weak opioids (31.7%), antiepileptics (10.9%), and strong opioids (10.9%).

The most common therapies used for neuropathic pain treatment are physical therapy, relaxation therapy, massage therapy, psychological therapy, and acupuncture accompanied by pain counseling.

Furthermore, in neuropathic pain caused by medical conditions such as diabetes, treatment may emphasize the management of the condition and improvement of quality of life by preventing further nerve damage.

In some cases, an invasive or implantable device may be used to manage the pain.

Collard Green is a species of Brassica Oleracea, belonging to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a potential compound for the treatment of neuropathic pain, researchers investigated sulforaphane (SFN), a derivative of glucoraphanin present in cruciferous vegetables on inflammation-related diseases.

According to the tested analysis, SFN showed an anti-nociceptive effect in a neuropathic pain mouse model, sciatic nerve chronic constriction injury (CCI).

Furthermore, SFN injected intraperitoneally for 7 days inhibited pain behaviors, including mechanical allodynia and thermal hyperalgesia in CCI mice.

Moreover, SFN at a dose-dependently also attenuated CCI-induced pain behavioral hypersensitivity, by inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 that cause neuropathic pain in mice and exhibiting the production of an anti-inflammatory cytokine such as IL-10 associated with pain relief.

More importantly, CCI enhancement of COX2 and iNOS in the induction of nerve injury were also counteracted by the administration of SFN.

Additionally, SFN treatment also increased the CCI-induced increase in µ-opioid receptors that are responsible for the analgesics, in injured sciatic nerves.

Based on the results, researchers said, "SFN has both anti-nociceptive and anti-inflammatory actions"

Taken altogether, collard green processed a high amount of SFN may be considered supplements for the prevention and treatment of neuropathic pain, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice by Wang C1, Wang C. (PubMed)
(2) The prevalence of probable neuropathic pain in the US: results from a multimodal general-population health survey by Marco D DiBonaventura,1 Alesia Sadosky,2 Kristen Concialdi,1 Markay Hopps,2 Ian Kudel,1Bruce Parsons,2 Joseph C Cappelleri,3 Patrick Hlavacek,2 Andrea H Alexander,2Brett R Stacey,4 John D Markman,5 and John T Farrar. (PMC)

#Herbal #Ashwagandha's #Withanolide D (WND) Exerts Cytostatic Effect that Causes the Cancer Cell Death and Apoptosis, Researchers Suggest

Kyle J. Norton

Multiple myelomas (Myeloma) is a type of cancer that originates from plasma cells in the bone marrow.
The disease is a condition of DNA alternation of white blood cell normally responsible for the production of antibodies to protect our body against infection with some characteristics.

According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).

Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.
The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

The exact causes of MS are unknown. Epidemiologically, the increase in age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affect blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation
The most common symptoms of MS are* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.

* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. The most common infections found to be pneumonia and pyelonephritis.

* Anemia
As a result, malignant plasma cells have to interfere with the normal production of red blood cells.

* Bleeding
Due to the lower production of the platelet.

* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine accumulated in the bloodstream.

* Neurological symptoms
Hypercalcemia is a result of the breakdown of the bone caused of the release of calcium into the bloodstream.

However, most people with some of the above symptoms never developed MS.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound for the treatment of tumor of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).

According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.

In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.

However, WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cell drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involving in the development of resistance of cancer cells to chemotherapeutic drugs.

Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".


Taken together, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All rights reserved)
Health article writer and researcher; Over 10,000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, Best Before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for Shorty Award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)

#Withanolide D (WND) Isolated From #Herbal #Ashwagandha Exerts Anti Multiple Myeloma Activity by Its Cytostatic Effects, Researchers Say

Kyle J. Norton

Multiple myeloma (Myeloma) is a type of cancer that originated from plasma cells in the bone marrow.
The disease is a condition of DNA alternation of white blood cells normally responsible for the production of antibodies to protect our body against infection with some characteristics.

According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).

Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.

The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.


The exact causes of MS are unknown. Epidemiologically, the increase in age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affect blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation
The most common symptoms of MS are* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.

* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. The most common infections found to be pneumonia and pyelonephritis.

* Anemia
As a result, malignant plasma cells have to interfere with the normal production of red blood cells.

* Bleeding
Due to the lower production of the platelet.

* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine to accumulate in the bloodstream.

* Neurological symptoms
Hypercalcemia is a result of the breakdown of the bone caused by the release of calcium into the bloodstream.

However, most people with some of the above symptoms never developed MS.

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound for the treatment of tumors of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).

According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.

In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.

However, WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cells' drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involved in the development of resistance of cancer cells to chemotherapeutic drugs.

Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".

Taken together, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending to the result of a larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)

#Withaferin A (WA) Isolated from #Herbal Ashwagandha inhibits Parameters and Pathways Associated with the Onset of Cancer, Researchers Find

Kyle J. Norton

Cancer is a group of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.

At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including the unintended weight loss, loss of appetite, fatigue and tiredness and gastrointestinal problems.

Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.

Pre-cancer is a medical condition that likely develops into cancer if untreated.
Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition and the most common plasma cell disorder.

In other words, monoclonal myeloma gammopathies is a precancerous condition that may cause myeloma, a cancer of white blood cell disorder.

Multiple myelomas. also known as plasma cell myeloma or Kahler's disease, is a type of abnormal growth of plasma cells collected in the none marrow where they grow and multiply to interfere with the production of normal blood cells.

According to the study by the Harvard Medical School, paraprotein, an abnormal antibody produced by the plasma cell myeloma not only can cause kidney problem but also interference with the Roche automated total bilirubin, including total bilirubin (TBIL), direct bilirubin (DBIL), or HDL-cholesterol (HDL-C).

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound that processes the anti-cancer property, researchers examined the effects of Withaferin A (WA) isolated from the plant Withania somnifera, antitumor effects on a multiple myeloma cell model.

According to the results from Ingenuity Pathway Analysis and Western blot, WA exerted a significant action against monoclonal gammopathy of undetermined significance (MGUS) and related disorders.

Furthermore, WA showed a strong and massive blockage on both proteotoxic and oxidative stress response pathways by targeting protein networks such as multicatalytic proteinase complex, associated with the risk of monoclonal gammopathy.

In other words, WA mediated apoptosis is preceded by simultaneous targeting of cellular stress response pathways like proteasome degradation, autophagy and unfolded protein stress response.


Based on the findings, researchers said, "the combined approach can be used for other types of cancer and/or other promising multifunctional compounds, thereby increasing the potential development of new antitumor therapies".

Taken altogether, Ashwagandhaprocessed abundantly WA may be considered a functional herb for the modulation of the monoclonal myeloma gammopathies, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies by Dom M1, Offner F2, Vanden Berghe W1, Van Ostade X. (PubMed)
(2) Multiple Myeloma by Kyle J. Norton

#Herbal #Anise's #Anethole Inhibits #HydrogenPeroxide (H2O2) Induced #BoneLoss That Causes the Onset of #Osteoporosis, According to Studies

Kyle J. Norton

Anise may have a potential and substantial effect in reduced risk and progression and treatment of osteoporosis, some scientists suggested.

Osteoporosis is considered as a bone disease that caused substantial loss of bone density and deterioration of bone tissue. In other words, the disease is caused by the body's inability to make new bone to replace bone loss.

According to statistics, osteoporosis affects an estimated 75 million people in Europe, the USA, and Japan, causing more than 8.9 million fractures annually.

The disease is also the leading cause of fracture. The International Osteoporosis Foundation wrote, " For the year 2000, there were an estimated 9 million new osteoporotic fractures, of which 1.6 million were at the hip, 1.7 million were at the forearm and 1.4 million were clinical vertebral fractures. Europe and the Americas accounted for 51% of all these fractures, while most of the remainder occurred in the Western Pacific region and Southeast Asia ".

Osteoporosis is not caused by a single factor, The combination factors below are associated to the causes of the disease, including low levels of estrogen in women and testosterone in men due to aging, abnormal levels of a hormone that plays an important role in regulated bone growth, such as parathyroid hormone and growth hormone.

Decreased levels of vitamin D or mineral calcium also have a strong implication in accelerated bone loss.

Some researchers suggested that genetic mutation diseases such as multiple myeloma, long-term unhealthy diet, and lifestyle and use of medication may also have a direct effect on the disease development.

If you experience symptoms of frequent back pain, loss of height over time, a stooped posture,... and bone fracture that occurs much more easily than normal, you may have osteoporosis.

Conventional medicine used to treat osteoporosis, such as Bisphosphonates, Denosumab, Parathyroid Hormone Hormone Therapy,... and SERMs (Selective Estrogen Receptor Modulators) may be effective in slowing down bone loss and reduced risk of fracture. However, the medicine may induce certain side effects such as ulcers of the esophagus, upper GI irritation, irregular heartbeat, low calcium levels, skin rash Joint, bone,...... and muscle pain

In serious cases, although it is rare, the medication may cause osteonecrosis of the jaw and increased production of a parathyroid hormone that can lead to fragile bones, risk of kidney stones, excessive urination, abdominal pain,..... psychological symptoms of depression and forgetfulness.

If you are taking osteoporosis medicine, please make sure that you understand the risk and side effects.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region.

The herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and as an anti stomachic, antiseptic, anti-spasmodic, .... agent.

Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the investigation of the herbal selective estrogen receptor modulators or SERMs effect on the risk of osteoporosis by comparison of plant aqueous extracts derived from Greek flora (Sideritis euboea, Sideritis clandestina, Marticaria chamomilla, and Pimpinella anisum), researchers at the Medical School, University of Athens found that all extracts exert profound activities in stimulating the differentiation and mineralization of osteoblastic cell culture.

Further analysis, also discovered that all plant extracts at the concentration range of 10-100 microg/mL, including Anise induced osteoblastic cell differentiation in the formation of bone and improved bone density.

These results indicated that Anise and other plant extracts may comprise a substantial anti-estrogenic effect in reducing the risk of osteoporosis in a dose-dependent manner.

Also, in the evaluation of (E)-anethole, a major bioactive compound isolated from Anise protective effect on H2O2-induced alterations in collagen metabolism, researchers showed that application of anethole of 0.5 µM for 1 h completely prevents the alternation of cells treated with 300 µM H2O2.

In detail, Anethole injection inhibited the effect of 300 µM H2O2 that caused a significant decrease in collagen biosynthesis of 54 %, correlated with alterations of type I collagen mRNA expression in the osteoblasts in initiated higher bone turnover.

Hydrogen peroxide (H2O2), the reactive oxygen species(ROS) is responsible for inducing bone loss.

Type I collagen, a determinant of the biomechanical properties of bone tissue, is a type of collagen that forms large, eosinophilic fibers known as collagen fibers in the human body. Alternation of type I collagen mRNA causes the opposite effect.

Additional differentiation also revealed that Anise anethole administration at 10 µM, exerts most efficient suppression in the ameliorated expression of MMP-2 and MMP-9 caused by H2O2 induced alterations in collagen metabolism, contributing to the 8 % decrease in the amount of collagen secreted-into the medium.

Matrix metalloproteinases (MMPs) are enzymes process function in processing certain components of bone tissue, through the expression of osteoclasts and osteoblasts.

The result suggested that the application of H2O2 not only directly activates MMPs but also causes a decrease in the expression of their inhibitors, such as TIMP2, a metastasis suppressor in initiated alterations of collagen metabolism in bone.

The loss of MMP-9 improved the connectivity density of the trabeculae, whereas the loss of MMP-2 reduced this parameter. Similar differential effects in architecture were observed in the L5 vertebra, but bone volume fraction was lower for both MMP-2 and MMP-9 (in mice study) "

Taken together, Anise and its bioactive anethole may be considered a functional herb for reduced risk and treatment of osteoporosis caused by collagen loss in bone. However, intake of Anise supplements should be taken with extreme care in prevented toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties by Kassi E1, Papoutsi Z, Fokialakis N, Messari I, Mitakou S, Moutsatsou P.(PubMed)
(2) Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblast by Anna Galicka, Rafał Krętowski, Jolanta Nazaruk, and Marzanna Cechowska-Pasko(PubMed)
(3) Differential Effects Between the Loss of MMP-2 and MMP-9 on Structural and Tissue-Level Properties of Bone by Jeffry S Nyman,1,2,3,4 Conor C Lynch,5 Daniel S Perrien,2,3 Sophie Thiolloy,6 Elizabeth C O’Quinn,2,7 Chetan A Patil,4 Xiaohong Bi,2,4 George M Pharr,8,9 Anita Mahadevan-Jansen,4 andGregory R Mundy(PMC)
(4) Osteoporosis, a unitary hypothesis of collagen loss in skin and bone by Shuster S1.(PubMed)
(5) Osteoporosis - Incidence and burden by the International Osteoporosis Foundation

The Effects of #Herbal #Ashwagandha Cytostatic Activities on #MultipleMyeloma, Scientists Say

By Kyle J. Norton

Multiple myeloma (Myeloma) is a type of cancer that originated from plasma cells in the bone marrow.

The disease is a condition of DNA alternation of white blood cells normally responsible for the production of antibodies to protect our body against infection with some characteristics.

According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).

Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.
The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation
Most common symptoms of MS are* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.

* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. The most common infections found to be pneumonia and pyelonephritis.

* Anemia
As a result, malignant plasma cells have to interfere with the normal production of red blood cells.

* Bleeding
Due to the lower production of the platelet.

* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine to accumulate in the bloodstream.

* Neurological symptoms
Due to hypercalcemia, as a result of the breakdown of the bone caused by the release of calcium into the bloodstream.

However, most people with some of the above symptoms never developed MS.


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of tumor of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).

According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.

In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.

However, WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cells' drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involved in the development of resistance of cancer cells to chemotherapeutic drugs.

Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)

Beta-Sitosterol, the Potential Anti Multiple Myeloma Supplement

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth that starts in the tissue of specific organs.

Most cases of cancer overtime after penetrating into deeper layers of the affected organs, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Pre-cancer is a medical condition that likely develops into cancer if untreated.

Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition and the most common plasma cell disorder.

In other words, monoclonal myeloma gammopathies is a precancerous condition that may cause myeloma, a cancer of white blood cell disorder.

Multiple myelomas (Myeloma) is a type of cancer originated from plasma cells in the bone marrow that produces the white blood cells which are normally responsible for the production of antibodies to protect our body against infection.

Over time, multiple myeloma can lead to the accumulation of cancer cells in the bone marrow, overcrowding out healthy blood cells.

According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).

Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.

The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the anti-cancer effects of beta-sitosterol (BS), a plant-derived sterol on multiple myeloma U266 cells.

According to the experimental analysis, Beta-sitosterol induced cytotoxicity increased sub-G1 apoptotic population and activated caspase associated with the pro-apoptotic activity and blocked the cancer cell in the energetic converting process in U266 cells.

Furthermore, Beta-sitosterol promoted ROS expression by activating the enzymes involved in free radical production in U266 cells. 

Moreover, beta-sitosterol attenuated the induction of new blood vessels by the cancer cells to promote proliferation and suppressed pathways associated with suppression of cancer cell apoptosis and tumor progression.

Additionally, beta-sitosterol also suppressed the proteins associated with DNA repair. sub-G1 accumulation, proliferation, and pro-oncogenic function in U266 cells.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of multiple myeloma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells by Sook SH1, Lee HJ, Kim JH, Sohn EJ, Jung JH, Kim B, Kim JH, Jeong SJ, Kim SH. (PubMed)

Arnica's Bioactive Sesquiterpene Lactones Block the Spreading of Leukemia Cells, Scientists Find

By Kyle J. Norton

Arnica may have a substantial and sustainable effect in reducing the risk, progression, and treatment of leukemia, some scientists suggested.

The results of these reports were conducted by a number of respectable institutes, including the Chonnam National University and Westfälische Wilhelms-Universität, and published online on the database of medical literature.

Leukemia is a medical condition characterized by cell growth uncontrollable and disorderly produced by the body's blood-forming tissues, including the bone marrow and the lymphatic system. In most cases, it is the result of abnormal white blood cells, which don't function properly.

According to reliable statistics, approximately every 3 minutes one person in the United States (US) is diagnosed with leukemia. New cases of leukemia, lymphoma, and myeloma are expected to account for 10 percent of 1,735,350 new cancer cases diagnosed in the US in 2018.

The exact causes of leukemia are unknown. However, certain risk factors including smoking, mutation gene inherited from parents such as Down syndrome. blood disorders such as myelodysplastic syndrome are associated with an increased risk of the disease.

Some researchers also suggested that people who have previous treatment for cancer with chemotherapy or radiation are at higher risk of cancer development.

Most common symptoms of leukemia include fever or chills, persistent fatigue and weakness frequent or severe infections due to dysfunction of the immune system caused by immature white blood cells produced.

Some patients may also experience symptoms of unattended weight loss, swelling lymph nodes,... and enlarged liver or spleen.


If you experience some of the above symptoms, please check with your doctor to rule out the possibility.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of the skin, tissues, organs, etc.

Leukemia is a chronic condition characterized by high numbers of abnormal white blood cells in the bone marrow.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the investigation of the effect of helenalin, a bioactive chemical compound isolated from Arnica on the human promyelocytic leukemia HL-60 cell line, researchers found that application of the compound exerts a significant effect in induced HL-60 cell differentiation through the expression of granulocytes, white blood cells with secretory granules in its cytoplasm, at a concentration-dependent manner.

Further analysis, injection of helenalin inhibited HL-60 through activating the protein kinase C (PKC) inhibitor with a function to act as ruboxistaurin in signaling molecules that link to multiple cellular processes of cancer.

Moreover, researchers also found that helenalin also inhibits HL-60 proliferation through activating the extracellular signal-regulated kinase (ERK) inhibitors which are used in some cancer therapy in controlling diverse tumor cellular processes such as proliferation, survival, and motility.



Protein kinase C (PKC) is a family of protein kinase enzymes with the function of controlling the expression of other proteins through certain mechanisms.

Additional differentiation also suggested that helenalin induced expression of protein kinase C (PKC) inhibitors without interfering with PKC activity and protein level of PKC beta I and PKC beta II isoforms activities which have been found to promote progression of human cancer.

Interestingly, helenalin also inhibited HL-60 through increasing levels of protein kinase R-like endoplasmic reticulum kinase (PERK) with the function of triggering cancer cell death in a concentration-dependent manner.


Finally, researchers also indicated that the inhibition of HL-60 by helenalin is also carried out through ameliorating levels of NF-kappa, with aberrant activity in enabling leukemia cells to evade apoptosis and stimulate proliferation.

High levels of NF-κB have been detected in most of the patients with acute myeloid leukemia (AML).


These results postulated that helenalin isolated from Arnica inhibits the expression of human promyelocytic leukemia HL-60 cell line through many different pathways involved several aspects in tumor cellular differentiation.

More importantly, in the different aspects of the study, Dr. Dirsch VM and colleagues found that sesquiterpene lactones also exerted a significant cytotoxic effect in triggering leukemia cell apoptosis.

According to cell morphology, four compounds found in sesquiterpene lactones, including ambrosin, alantolactone, hymenin, and helenalin induced apoptosis of Jurkat leukemia T cells, individually, through inducing apoptosis of nuclei and the outer surface of the cell membrane.

Taken together, Arnica and its bioactive sesquiterpene lactones, particularly helenalin may be used to ameliorate the risk, progression, and treatment of Leukemia.

However, additional data collection on large example size and multi-centers studies performed with human consumption of herbal arnica or its' bioactive sesquiterpene lactones during the course of the disease will be necessary to complete the picture of garlic anti-leukemia possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone by Kim SH1, Oh SM, Kim TS. (PubMed)
(2) Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis by Dirsch VM, Stuppner H, Vollmar AM. (PubMed)

Herbal Ashwagandha inhibits the Pre-Cancer Stage of Multiple Myeloma in Vitro

By Kyle J. Norton

Cancer is a group of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.

Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.

At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including the unintended weight loss, loss of appetite, fatigue and tiredness and gastrointestinal problems.

Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.

Pre-cancer is a medical condition that likely develops into cancer if untreated.

Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition and the most common plasma cell disorder.

In other words, monoclonal myeloma gammopathies is a precancerous condition that may cause myeloma, a cancer of white blood cell disorder.

Multiple myelomas. also known as plasma cell myeloma or Kahler's disease, is a type of abnormal growth of plasma cells collected in the none marrow where they grow and multiply to interfere with the production of normal blood cells. 

According to the study by the Harvard Medical School, paraprotein, an abnormal antibody produced by the plasma cell myeloma not only can cause kidney problem but also interference with the Roche automated total bilirubin, including total bilirubin (TBIL), direct bilirubin (DBIL), or HDL-cholesterol (HDL-C).

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound that processes the anti-cancer property, researchers examined the effects of Withaferin A (WA) isolated from the plant Withania somnifera, antitumor effects on a multiple myeloma cell model.
According to the results from Ingenuity Pathway Analysis and Western blot, WA exerted a significant action against monoclonal gammopathy of undetermined significance (MGUS) and related disorders.

Furthermore, WA showed a strong and massive blockage on both proteotoxic and oxidative stress response pathways by targeting protein networks such as multicatalytic proteinase complex, associated with the risk of monoclonal gammopathy.

In other words, WA mediated apoptosis is preceded by simultaneous targeting of cellular stress response pathways like proteasome degradation, autophagy and unfolded protein stress response.

Based on the findings, researchers said, "the combined approach can be used for other types of cancer and/or other promising multifunctional compounds, thereby increasing the potential development of new antitumor therapies".

Taken altogether, Ashwagandhaprocessed abundantly WA may be considered a functional herb for the modulation of the monoclonal myeloma gammopathies, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies by Dom M1, Offner F2, Vanden Berghe W1, Van Ostade X. (PubMed)
(2) Multiple Myeloma by Kyle J. Norton

Herbal Ashwagandha Exerts Cytostatic Effect Against Multiple Myeloma In Vitro

By Kyle J. Norton

Multiple myelomas (Myeloma) is a type of cancer originated from plasma cells in the bone marrow.

The disease is a condition of DNA alternation of white blood cell normally responsible for the production of antibodies to protect our body against infection with some characteristics.

According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).

Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.

The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation

Most common symptoms of MS are

* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.

* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. Most common infections found to be pneumonia and pyelonephritis.

* Anemia
As a result of malignant plasma cells has to interfere with the normal production of red blood cells.

* Bleeding
Due to the lower production of the platelet.

* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine accumulated in the bloodstream.

* Neurological symptoms
Due to hypercalcemia, as a result of the breakdown of the bone cause of the release of calcium into the bloodstream.

However, most people with some of the above symptoms never developed MS.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of tumor of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).

According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.

In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.

However, , WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cells drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involving in the development of resistance of cancer cells to chemotherapeutic drugs.

Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)

Bioactive Compound Sulforaphane (SFN) Isolated from Collard Greens, Processes Anti-Neuropathic Pain in Vivo

By Kyle J. Norton

Neurological disorders are a class of diseases of the nervous system characterized by the structural damage, biochemical or electrical abnormalities in the brain, spinal cord or nerves.

Neurodegenerative disease is a type of neurological disorder associated with the progressive loss of neuron in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Neuropathic pain is a type of pain that affects the somatosensory nervous system due to damage or disease. Abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia) are some of the most common forms of neuropathic pain found in patients.

There are no obvious causes of neuropathic pain. However, medical condition such as alcoholism, amputation, diabetes, nerve problems, HIV infection or AIDS, multiple myeloma, multiple sclerosis and shingles, and chemotherapy are some prevalent factors of neuropathic pain.

According to the joint study conducted led by the Health Outcomes Practice, there are no published data on the broad prevalence of neuropathic pain (NeP) in the US. However, the 15,751 respondents reported pain (63.7%), of 2,548 data suggested that 10% American may suffer from neuropathic pain (NeP). The rate of NeP in Blacks and Hispanics ethnicity was consistently higher compared to White

Most common treatments of NeP are the use of nonsteroidal anti-inflammatory drugs (44.2%), followed by weak opioids (31.7%), antiepileptics (10.9%), and strong opioids (10.9%).

Most common therapies used for neuropathic pain treatment are physical therapy, relaxation therapy, massage therapy, psychological therapy, and acupuncture accompanied by pain counseling.

Furthermore, in neuropathic pain caused by medical conditions such as diabetes, treatment may emphasize on the management of the condition and improvement of quality of life by preventing further nerve damage.

In some cases, an invasive or implantable device may be used to manage the pain.

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a potential compound for the treatment of neuropathic pain, researchers investigated sulforaphane (SFN), a derivative of glucoraphanin present in cruciferous vegetables on inflammation-related diseases.

According to the tested analysis, SFN showed an anti-nociceptive effect in a neuropathic pain mouse model, sciatic nerve chronic constriction injury (CCI).

Furthermore, SFN injected intraperitoneally for 7 days inhibited the when pain behaviors, including mechanical allodynia and thermal hyperalgesia in CCI mice.

Moreover, SFN at a dose-dependently also attenuated CCI-induced pain behavioral hypersensitivity, by inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 that cause d neuropathic pain in mice and exhibiting the production of an anti-inflammatory cytokine such as IL-10 associated with pain relief.

More importantly, CCI enhancement of COX2 and iNOS in the induction of nerves injury were also counteracted by the administration of SFN.

Additionally, SFN treatment also increased the CCI-induced increase in µ-opioid receptors that are responsible for the analgesics, in injured sciatic nerves.

Based on the results, researchers said, "SFN has both anti-nociceptive and anti-inflammatory actions"

Taken altogether, collard green processed a high amount of SFN may be considered supplements for the prevention and treatment of neuropathic pain, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-nociceptive and anti-inflammatory actions of sulforaphane in chronic constriction injury-induced neuropathic pain mice by Wang C1, Wang C. (PubMed)
(2) The prevalence of probable neuropathic pain in the US: results from a multimodal general-population health survey by Marco D DiBonaventura,1 Alesia Sadosky,2 Kristen Concialdi,1 Markay Hopps,2 Ian Kudel,1Bruce Parsons,2 Joseph C Cappelleri,3 Patrick Hlavacek,2 Andrea H Alexander,2Brett R Stacey,4 John D Markman,5 and John T Farrar. (PMC)

Turmeric Promotes Myeloma Cancer Cells Apoptosis

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth that starts in the tissue of specific organs.

Most cases of cancer overtime after penetrating into deeper layers of the affected organs, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Multiple myelomas (Myeloma) is a type of cancer originated from plasma cells in the bone marrow that produces the white blood cells which are normally responsible for the production of antibodies to protect our body against infection.

Over time, multiple myeloma can lead to the accumulation of cancer cells in the bone marrow, overcrowding out healthy blood cells.

According to the statistics provided by the American Cancer Society, In the US, the lifetime risk of getting multiple myeloma is 1 in 132.  In 2019, about 32,110 new cases will be diagnosed including 18,130 in men and 13,980 in women.

The causes of multiple myelomas are unidentified. However certain factors have been found to increase the risk of the conditions, inclduing

* Age
If you are between 50 and 70 years old, you are at higher risk to develop multiple myeloma.

*Gender
Men are more likely to develop multiple myeloma than women.

*Race
Cancer tends to affects blacks more often than whites.

* Previous multiple myeloma
People who previously had been treated with multiple myeloma are at a higher risk to develop it again.

*Exposed to certain chemicals
Increased risk of multiple myeloma if you are exposed to certain chemicals such as occupation.

* Family history
If a direct member of the family has multiple myeloma, the risk of the disease is increased.

* Radiation
Increased risk of cancer if you are exposed to radiation, such as radiation exposure of nuclear accident.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential ingredient for the treatment of multiple myeloma,, researchers examined the synergistic apoptotic effects on arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma (MM) cell line U266.

The study included U266 cells cultured with MGN-3 (50 or 100μg/ml) and curcumin (2.5-10μM) for 3 days. 

Based on the results of cells differentiation assays, MGN-3 alone or curcumin alone showed a significant anti-proliferation of U266 cells at a dose-dependent inhibition manner.

The synergistic effect was noticed at maximized at 100μg/ml MGN-3 plus 10μM curcumin, according to the analysis of post-treatment by inducing the 87% decrease in cell number and a 2.6 fold increase in the percentage of apoptotic cells.

This effect was also exhibited cell cycle arrest in the G0-G1 phase by a 53% decrease in the percentage of cells.in the G0-G1 phase.

More precisely, the combination exerted a strong activity in the stimulation of pro-apoptosis and inhibition of anti-apoptotic by the decreased and increased expression of Bcl-2 and Bax, respectively.

Collectively, researchers wrote in the final report, "MGN-3 and curcumin synergize in the induction of U266 cell apoptosis".

Taken altogether, turmeric used alone or combined with arabinoxylan rice bran may be considered supplements for the prevention and treatment of multiple myeloma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin-induced promoter hypermethylation of the mammalian target of rapamycin gene in multiple myeloma cells by Chen J1, Ying Y2, Zhu H1, Zhu T3, Qu C1, Jiang J3, Fang B. (PubMed)
(2) Synergistic apoptotic effect of arabinoxylan rice bran (MGN-3/Biobran) and curcumin (turmeric) on human multiple myeloma cell line U266 in vitro by Ghoneum M1, Gollapudi S. (PubMed)

Herbal Artichoke, the Potential Anti Lymphoma Natural Remedy, According to Researchers

By Kyle J. Norton 


Lymphoma originated in the lymphatic system is a type of cancer that affects the white blood cells lymphocytes of the immune system.

Non-Hodgkin's lymphomas are the most common types of lymphoma 

According to statistics provided by the Leukemia and Lymphoma Society, in the US, approximately over 1,30,000 people are either living with or are in remission from, leukemia, lymphoma or myeloma, causing the death of over 9% of all cancer death in 2018.

 60 years of age and over, weakened immune system, previous exposure to toxic chemicals, previous chemotherapy or radiation therapy are some of the most common prevalent risk factors of lymphoma.

Interestingly, most people with some of the above risk factor have never developed lymphoma.

Some researchers suggested that people infected by the HIV virus are also at an increased incidence of the disease, probably due to immune suppression.

Dr, K L Grogg, in the concern of immune deficiency in patients infected by the HIV virus in the risk of lymphoma said, The incidence of lymphoma in patients with HIV infection greatly exceeds that of the general population.

And, "The increased risk for lymphoma appears related to multiple factors, including the transforming properties of the retrovirus itself, the immunosuppression and cytokine dysregulation that results from the disease, and, most importantly, opportunistic infections with other lymphotropic herpes viruses such as Epstein–Barr virus and human herpesvirus 8".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researchers on finding a natural chemo compound for the treatment of lymphoma examined the anticancer activity of the sesquiterpene lactone, the major constituent of the artichoke leaves extracts.

The aim of the study was to investigate the effects of cynaropicrin, a major compound from the sesquiterpenes on the grown of a number of leukocyte cancer cell lines.

Injection of cynaropicrin exerted potently effect in inhibiting the proliferation of leukocyte cancer cell lines, such as U937.

According to the flow-cytometric assay, cynaropicrin displayed a strong inhibition against the cancer cell line by exhibiting the expression of free radical cytotoxic effect.

The cancer cell apoptosis in the cell cycle arrest at G1/S phase observed by the DNA fragmentation and morphological analyses in U937.

Use the combination of antioxidants such as l-cysteine and N-acetyl-l-cysteine, reactive oxygen species scavengers showed to reduce the cytotoxic activity of the cynaropicrin against U937.

These results clearly suggested that mediation of reactive oxygen species and protein associated with the pro-apoptotic activity were attributed to the effect of cynaropicrin in the inhibition of lymphoma cancer.

Dr. and colleagues after taking into account co and confounders wrote in the final report, "cynaropicrin may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro-apoptotic activity".

Taken altogether, artichoke processed abundantly bioactive compound sesquiterpene lactone cynaropicrin may be considered a functional remedy for the prevention and treatment of lymphoma, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
 lymphoma
(1) Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines by Cho JY1, Kim AR, Jung JH, Chun T, Rhee MH, Yoo ES. (PubMed)
(2) HIV infection and lymphoma by K L Grogg, R F Miller, and A Dogan. (PMC)

Bilberry May Process Anti Cancers Potency, Researchers Say

By Kyle J. Norton

Bilberry may be the potential target used by conventional medicine in the future for the treatment of cancer with no side effects, according to studies.

Cancer is a class of medical condition characterized by cell growth irregularly due to the alternation of cell DNA.

Most cases of cancers begin in the cells on the surface of the inner lining of the body tissues and do not cause any symptoms at the early stage.

However, invasive cancer at the advanced stage can cause localized symptoms accompanied by the cancer general symptoms and its cells can also travel a distance away from the original site to infect other healthy tissues and organs, leading secondary metastasis.

According to the US government statistics, the prevalent risk of cancer development is 439.2 per 100,000 men and women per year based on 2011–2015 cases, causing the death of 163.5 per 100,000 men and women per year.

The exact causes of cancer are unknown. Epidemiologically, certain factors are associated with the prevalent risk of cancer including age, ethnicity, long-term exposure to toxic chemicals, and genetic preposition.

Some researchers suggested that the widespread obesity in the Western world, particularly in North America may have a strong impact on the increased risk of cancer. According to statistics, over 68% of American are either overweight or obese.

Dr. Giovanni De Pergola, the lead scientist in the assessment obese in cancer risk said, "The number of cancer cases caused by being obese is estimated to be 20% with the increased risk of malignancies being influenced by diet, weight change, and body fat distribution together with physical activity".

And, "Reports from the International Agency for Research into Cancer and the World Cancer Research Fund (WCRF) have shown that the strongest evidence exists for an association of obesity with the following cancer types: endometrial, esophageal adenocarcinoma, colorectal, postmenopausal breast, prostate, and renal, whereas the less common malignancies, are leukemia, non-Hodgkin's lymphoma, multiple myeloma, malignant melanoma, and thyroid tumors".

The results strongly clearly suggested if you are obese, your risk of cancer is increased substantially compared to non-obese individuals.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Scientists on finding a natural and potential compound for the treatment of cancer examined the anthocyanins anticancer activity in rodent models of cancer in-vitro and in- vivo.

Bilberry anthocyanins as chemopreventive agents showed a significant effect in 25 colorectal cancer patients. The result has opened a new window of opportunity in translating the findings from laboratory to clinic.

According to the study, anthocyanins treated cancer cells by stimulating the production of the tumor suppressor genes.

Application of anthocyanins also inhibited the cancer cell proliferation through activating the protein associated with cell death programming.

Dr. Sehitoglu MH and colleagues wrote in the final report, "his review we bring to limelight how anthocyanins induced apoptosis in cancer cells via activation of extrinsic and intrinsic pathways".

In order to reveal additional information about bilberry anti-cancer effects, researchers investigated the anthocyanins (A(V.uli)) bioactivity on suppressing cancer cells.

Malvidin, the major compound isolated from A(V.uli) at a dose-dependent inhibited cancer cell proliferation with an IC(50) (50% inhibitory concentration) value of 50 µg/ml.

The findings strongly reconfirmed the anti-cancer effects of anthocyanin extraction. A(V.uli) from the bilberry.

Taken altogether, bilberry processed a high amount of bioactive compounds such as delphinidin, cyanidin, petunidin, peonidin, and malvidin may be considered a functional food for the prevention and treatment of cancer with no side effects, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anthocyanins: targeting of signaling networks in cancer cells by Sehitoglu MH1, Farooqi AA, Qureshi MZ, Butt G, Aras A. (PubMed)
(2) Anthocyanins extracted from Chinese blueberry (Vaccinium uliginosum L.) and its anticancer effects on DLD-1 and COLO205 cells by Zu XY1, Zhang ZY, Zhang XW, Yoshioka M, Yang YN, Li  J. (PubMed)
(3) Obesity as a Major Risk Factor for Cancer by Giovanni De Pergola* and Franco Silvestris. (PMC)

Herbal Arnica and Its' Bioactive Sesquiterpene Lactones That Block Cancer Cells of Leukemia From Spreading, Scientists Reveal

By Kyle J. Norton

Arnica may have substantial and sustainable effect in reducing risk, progression, and treatment of leukemia, some scientists suggested.

The results of these report were conducted by numbers of respectable institutes, including the Chonnam National University and Westfälische Wilhelms-Universität and published online on the database of medical literature.

Leukemia is a medical condition characterized by cells growth uncontrollable and disorderly produced by the body's blood-forming tissues, including the bone marrow and the lymphatic system. In most cases, it is the result of abnormal white blood cells, which don't function properly.

According to the reliable statistic, approximately every 3 minutes one person in the United States (US) is diagnosed with leukemia. New cases of leukemia, lymphoma, and myeloma are expected to account for 10 percent of 1,735,350 new cancer cases diagnosed in the US in 2018.

The exact causes of leukemia are unknown. However, certain risk factors including smoking, mutation gene inherited from parents such as Down syndrome. blood disorders such as myelodysplastic syndrome are associated with the increased risk of the disease.

Some researchers also suggested that people who have previous treatment for cancer with chemotherapy or radiation are at higher risk of cancer development.

Most common symptoms of leukemia include fever or chills,  persistent fatigue and weakness frequent or severe infections due to dysfunction of the immune system caused by immature white blood cells produced. 

Some patients may also experience symptoms of unattended weigh loss,  swelling lymph nodes,... and enlarged liver or spleen.

If you experience some of the above symptoms, please check with your doctor to rule out the possibility.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.

Leukemia is a chronic condition characterized by high numbers of abnormal white blood cells in the bone marrow.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the investigation of the effect of helenalin, a bioactive chemical compound isolated from Arnica on human promyelocytic leukemia HL-60 cell line, researchers found that application of the compound exerts a significant effect in induced HL-60 cell differentiation through the expression of granulocytes, white blood cells with secretory granules in its cytoplasm, at a concentration-dependent manner.

Further analysis, injection of helenalin inhibited HL-60 through activating the protein kinase C (PKC) inhibitor with a function to act as ruboxistaurin in signaling molecules that link to multiple cellular processes of cancer.

Moreover, researchers also found that helenalin also inhibits HL-60 proliferation through activating the extracellular signal-regulated kinase (ERK) inhibitors which are used in some cancer therapy in controlling diverse tumor cellular processes such as proliferation, survival, and motility.

Protein kinase C (PKC) is a family of protein kinase enzymes with function in controlling the expression of other proteins through certain mechanisms.

Additional differentiation also suggested that helenalin induced expression of protein kinase C (PKC) inhibitors without interfering with PKC activity and protein level of PKC beta I and PKC beta II isoforms activities which have been found to promote progression of human cancer.

Interestingly, helenalin also inhibited HL-60 through increasing levels of protein kinase R-like endoplasmic reticulum kinase (PERK) with function in triggering cancer cell death in a concentration-dependent manner.

Finally, researchers also indicated that the inhibition of HL-60 by helenalin are also carried out through ameliorating levels of NF-kappa, with aberrant activity in enabling leukemia cells to evade apoptosis and stimulate proliferation.

High levels of NF-κB has been detected in most of the patients with acute myeloid leukemia (AML).

These result postulated that helenalin isolated from Arnica inhibits the expression of human promyelocytic leukemia HL-60 cell line through many different pathways involved several aspects in tumor cellular differentiation.

More importantly, in the different aspect of the study, Dr. Dirsch VM and colleagues found that sesquiterpene lactones also exerted a significant cytotoxic effect in triggering leukemia cell apoptosis.

According to cell morphology, four compounds found in sesquiterpene lactones, including ambrosin, alantolactone, hymenin and helenalin induced apoptosis of Jurkat leukemia T cells, individually, through inducing apoptosis of nuclei and the outer surface of the cell membrane.

Taken together, Arnica and its bioactive sesquiterpene lactones, particularly helenalin may be used to ameliorate the risk, progression, and treatment of  Leukemia.

However, additional data collection on large example size and multi-centers studies performed with human consumption of herbal arnica or its' bioactive sesquiterpene lactones during the course of the disease will be necessary to complete the picture of garlic anti-leukemia possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone by Kim SH1, Oh SM, Kim TS. (PubMed)
(2) Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis by Dirsch VM, Stuppner H, Vollmar AM. (PubMed)