Herbal Dandelion (Taraxacum officinale) Effects on Rheumatoid Arthritis (RA)

By Kyle J. Norton

Arthritis, one of the Musculoskeletal disorders (MSDs) degenerative disease, is a general term of joint inflammation, affecting over 21% of the US population.


There are over 100 different forms of arthritis and related diseases. Rheumatoid arthritis (RA), is the common form of arthritis involved in chronic low-grade inflammation.

Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.

In other words, it is an autoimmune disorder caused by the immune system attacking some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.

Genes that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.

According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.

Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.

The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many older adults.

According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.

A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined taraxasterol (TAR), a bioactive active compound pentacyclic triterpenes isolated from Chinese medicine herb Taraxacum officinale effects on rheumatoid arthritis (RA).

In Vitro and Vivo, the application of TRA significantly suppressed the proteins involved in the production of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), IL-6, and IL-8 by blocking NOD-like receptor protein 3 (NLRP3) inflammasomes, activators of IL-1β secretion, particularly in the joints tissues of collagen-induced arthritis (CIA) mice.

Furthermore, the application of TRA also inhibited the enzymes involved in the productions of matrix metalloproteinases (MMPs), like MMP-1 and MMP-3 in HFLS-RA in vitro, degradation of the normal tissues.

Moreover, the injection of TRA also blocked nuclear factor kappa B (NF-κB) activation via modulating inhibitors of kappa B (IκB), IκB kinase (IKK) in the control of cytokines production and cell survival and transforming growth factor-β-activated kinase 1 (TAK1) to prevent the accumulation of ROS, resulting in cell death and inflammation.

Taken altogether, dandelion may be considered a remedy for the treatment of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritisfibroblast-like synoviocytes and rheumatoid arthritis progression in mice by Chen J1, Wu W2, Zhang M1, Chen C. (PubMed)

Herbal Angelica Protects the Neurons Against Traumatic Brain Injury (TBI)

By Kyle J. Norton

The central nervous system containing the brain and the spinal cord is the complex system of nerve tissues that controls the activities of the human body.

It is the center that controls our thoughts, the interpreter of our external environment, and body movement.

Traumatic brain injury (TBI) is a condition caused by sudden damage to the brain due to a blow or jolt to the head. 

Most cases of TBI are associated with car accidence and sports injuries.

The most common symptoms caused by TBI are the loss of consciousness induce-dazed, confusion or disorients, headache, dizziness or loss of balance, difficulty sleeping and the problem with speech

In severe cases, patients may also experience sensory problems, sensitivity to light or sound, memory or concentration problems, mood swings, and feeling depressed or anxious.

Conventionally, the treatment of TBI includes physical therapy, occupational therapy, speech therapy. psychological and vocational counseling, cognitive therapy,... depending on the location of the injury.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention and treatment of diseases associated with brain injury, researchers examined the effects of Astragali Radix (AR)-Radix Angelica Sinensis (RAS) activity on traumatic brain injury (TBI).

According to the chemical analysis, researchers discover that the effects of the combination against the traumatic brain injury (TBI) may be attributed to the 14 bioactive ingredients in AR-RAS, while 33 potential targets hit by these ingredients related to TBI.

The effectiveness of the combined herbal medicines according to the GO annotation analysis, was involved in the regulation of multiple biological processes by AR-RAS.

Additionally, 89 novel signaling pathways (P<0.05) were also found to underlie the effects of AR-RAS for TBI treatment.

According to the animal experiment, in vivo AR-RAS showed significantly induced tissue recovery and improved neurological deficits in the hippocampus of TBIrats on the 14th day.

More precisely, AR-RAS target the neurotrophin signaling pathways as a major related pathway to improve axonal growth.

Based on the findings, researchers said, "Our work illuminates the "multi-compounds, multi targets, and multi pathways" curative action of AR-RAS in the treatment of TBI by network pharmacology".

Taken altogether, Herbal Angelica used alone or combined with Astragali Radix may be considered a functional herbal medicine for the treatment of traumatic brain injury,  pending a larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury by Xie G1, Peng W2, Li P1, Xia Z1, Zhong Y1, He F3, Tulake Y4, Feng D1, Wang Y1, Xing Z. (PubMed)

Herbal Dandelion (Taraxacum officinale), a Natural Anti-Colitis Remedy

By Kyle J. Norton

Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.

Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).

* Inflammatory bowel disease (IBD) is the inflammation of chronic inflammation of digestive tract associated with symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss.

* Microscopic colitis is a disease involved in the inflammation of the colon or large intestine, associated with symptoms of watery diarrhea and cramping. Microscopic colitis is much less severe than other types of inflammatory bowel disease.

* Ischemic colitis is an inflammation of the large intestine caused by the injury-induced inadequate blood supply to the colon, leading to pain on the left side of the abdomen.

* Segmental colitis associated with diverticula is an inflammation that affects colonic luminal mucosa in segments due to diverticulosis, causing symptoms of bloody stools, sometimes accompanied by abdominal pain, cramping discomfort, or diarrhea.

* Radiation colitis is an inflammation of the large intestines in patients with radiation therapy, leading to symptoms of diarrhea, nausea, vomiting, and stomach cramps.

* Diversion colitis is an inflammation of the large intestines as a complication of ileostomy or colostomy. Most cases of diversion colitis often occur within the year following the surgery.

* Eosinophilic colitis is a rare disease associated with a type of white blood cell, due to injury and inflammation to the large intestine.

* Behcet's colitis is chronic immune-mediated, inflammatory disorder that only affect the intestines but also the joints, skin, eyes, and biliary tracts

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of inflammatory diseases, scientists examined the taraxacum officinale extract (TOE) effects on colitis.

According to the results of DSS-induced colitis treated with different concentrations of TOE for 8 days, TOE showed significant activity in the attenuation of the clinical symptoms, by lowering the inflammatory scoring and inhibiting the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

In other words, the efficacy of TOE in the treatment of colitis was associated with the activity in the induction of fatty acid degradation through the increased of the expression levels of Adh5, Aldh3a2, and Acox in breaking down fat and decreased the levels of CCL20, CCR6, and CXCL1 in cytokine-receptor signaling.

Additionally, TEO also enhanced the levels of S24-7 and adlercreutzia but decreased the number of anerostipes, Enterococcus, Enterobacteriaceae and peptostreptococcaceae to promote microbial imbalance or maladaptation

Based on the findings, researchers said, "TOE ameliorated DSS-induced colitis by regulating fatty acid degradation and microbial dysbiosis".

Taken altogether, dandelion may be considered a remedy for the protection against colitis, pending the confirmation of the larger sample size and multicenter human study.

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How To Get Rid Of Eye Floaters 
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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Taraxacum officinale extract ameliorates dextran sodium sulphate-induced colitisby regulating fatty acid degradation and microbial dysbiosis by Chen W1, Fan H1, Liang R1, Zhang R1, Zhang J1, Zhu J. (PubMed)

Dandelion (Taraxacum officinale), the Hepatoprotective Functional Herb

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.

Furthermore, the liver produces bile that not only aids the digestive function in food absorption but also builds strong cell membranes, produces vitamin D and steroid hormone.

Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body.

The hepatoprotective effect is the action of the prevention of the liver against liver damage or toxicity.

There is no single cause of liver diseases. Researchers suggested that virus such as hepatitis A, B, C, long-term excessive alcohol drinking and genetic mutation inherited from the parents is the major risk factors associated with the early onset of the diseases.

Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.

Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.

Sadly, the mortality rate infected by viral hepatitis has increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of liver injury, scientists examined the hepatoprotective activity of T. Officinale leaf extract against Acetaminophen (APAP)-induced hepatotoxicity.

According to the tested results, T. officinale decreased the thiobarbituric acid-reactive substance levels and prevent the decrease in sulfhydryl levels induced by 200 mg/kg APAP (p.o.).

Histopathological alterations, and increased levels of liver stress markers such as serum aspartate and alanine aminotransferases caused by APAP, were also inhibited by the application of T. Officinale at the doses of 0.1 and 0.5 mg/mL.

Moreover, T. Officinale extracts also enhanced the antioxidant and scavenger activity against 2,2-diphenyl-1-picrylhydrazyl and nitric oxide radicals.

Collectively, researchers said, "hepatoprotective effect of T. Officinale against the toxicity induced by APAP. The possible mechanisms involved include its scavenger activities against ROS and reactive nitrogen species, which are attributed to the content of phenolic compounds in the extract".

Taken altogether, dandelion may be considered a remedy for the protection of the liver functioning, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice by Colle D1, Arantes LP, Gubert P, da Luz SC, Athayde ML, Teixeira Rocha JB, Soares FA. (PubMed)

Herbal Angelica Protects the Liver and Kidney Against Injury Caused by Inflammatory Stress

By Kyle J. Norton

Inflammation is a natural response of the immune system in the stimulation of the production of inflammatory cytokines with an aim to protect our body against infectious agents in the acute phase of bodily injury and tissue damage.

Inflammation cancer classified into
*Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nerves system, the immune first line of defense stimulates the production of blood platelets to cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.

The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.

On the other hand, the kidneys are a pair of kidney-shaped organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.

More than a detoxed organ, the kidneys also maintain the body fluid balance, regulate the production of red blood cells and high blood pressure.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention and treatment of diseases associated with inflammatory injury, researchers examined the effects of Angelica Sinensis on its effects on liver and kidney injury in an animal model.

The study included mice that were subjected to hypodermic injection with D-gal (200 mg/kg) and orally gavaged with AS (20, 40, or 80 mg/kg) once a day for 8 successive weeks.

According to the tested analysis, AS significantly showed a strong improvement in the liver and kidney function, assessed by organ index and functional parameters.

Furthermore, AS pretreatment effectively ameliorated the histological deterioration caused by the injection of D-gal.

Moreover, the application of AS  attenuated the MDA stress marker levels in the kidney and liver by enhancing the activities and gene expressions of antioxidative enzymes produced by the host.

Pro-inflammatory cytokines associated with kidney and liver toxicity caused by the injection of D-gal-mediated such as iNOS, COX-2, IκBα, p-IκBα, and p65 were also attenuated by the AS, accompanied by the promoting of a protein involved in the regulation of proinflammatory expression in both hepatic and renal tissues.

Based on the results, researchers said, "AS pretreatment could effectively guard the liver and kidney of mice against D-gal-induced injury, and the underlying mechanism was deemed to be intimately related to attenuating oxidative response and inflammatory stress".

Taken altogether, herbal Angelica may be considered a remedy, for the protection of the liver and kidney against inflammatory stress. pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica sinensis Supercritical Fluid CO2 Extract Attenuates D-Galactose-Induced Liver and Kidney Impairment in Mice by Suppressing Oxidative Stress and Inflammation by Mo ZZ1,2, Lin ZX2, Su ZR1,3, Zheng L4, Li HL4, Xie JH5, Xian YF2, Yi TG4, Huang SQ6, Chen JP. (PubMed)

Cayenne Pepper in Reducing the Risk of Metabolic Dysregulation

By Kyle J. Norton

Cayenne pepper may be the next herbal medicine in reduced risk and treatment of metabolic dysregulation, a recent study suggested

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum Annuum, the family Solanaceae, native to subtropical and tropical regions. It has been used in traditional medicine to increase metabolism, enhance the circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

Metabolic dysregulation refers to abnormal function of the body in regulation of glucose tolerance, fasting glucose, insulin resistance, dyslipidemia,...., leading to insulin resistance, type 2 diabetes, and fatty liver disease.

Capsaicin, the major chemical compound used in dietary supplements attenuated metabolic dysregulation in genetically obese diabetic mice by enhancing expression of modulation of glucose and lipid metabolism involving its receptors.

In obesity-induced inflammation and the development of obesity-related metabolic disorders, cayenne capsaicin suppressed inflammatory responses in inducing glucose intolerance and enhancing fatty acid oxidation in fat tissues, affecting insulin resistance.

The chemical compound involvement in reduced visceral adipose fat, also lowered serum levels of fasting glucose, total cholesterol, and triglycerides, probably through limited fat accumulation in adipose tissues and reduced inflammation, and increased insulin sensitivity.

Dr. Leung FW. said," Clinical evidence supports the role of capsaicin as an anti-obesity agent. Both oral and gastrointestinal exposure to capsaicin increase satiety and reduce energy and fat intake and reduction in visceral abdominal fat" and "Thermogenesis and lipid metabolism-related proteins are altered upon capsaicin treatment in white adipose tissue".

Intake of cayenne for weight loss treatment-induced reduction in visceral abdominal fat may also improve metabolic regulation. Quality of doses should only be given by specialists to prevent toxicity.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


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Sources
(1) Dietary capsaicin attenuates metabolic dysregulation in genetically obese diabetic mice by Kang JH1, Tsuyoshi G, Le Ngoc H, Kim HM, Tu TH, Noh HJ, Kim CS, Choe SY, Kawada T, Yoo H, Yu R.(PubMed)
(2) Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet by Kang JH1, Goto T, Han IS, Kawada T, Kim YM, Yu R.(PubMed)
(3) Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice by Lee GR1, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH, Han IS.(PubMed)

Papaya, a Potential Food for the Treatment of Anemia, Researchers Find

By Kyle J. Norton

Scientists may have found a whole fruit for the treatment of anemia with no side effects, according to studies.

Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.

Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout your body.

There are many risk factors involved in the onset of the condition. Blood loss, such as from heavy menstrual bleeding, an ulcer, cancer, and regular use of some over-the-counter pain relievers, especially aspirin are some of the most common prevalent risk factors.

People with a long-term deficiency of folate and vitamin B-12 which play a critical role in the production of healthy red blood cells are also at an increased risk of Amenia.

Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. the Duliajan College study suggested that certain genes such as the βE-Globin Gene is associated with the onset of anemia.



Dr. SK Sharma, the lead scientists in examine the anemia in the Indian population surprisingly found that there is a high prevalence of anemia among children (78.9%), ever-married women (56.2%), pregnant women (57.9%), and never-married men (24.3%) in India.

The doctor continued after observing the levels of hemoglobin in the tested subjects, " Association of the lower level of hemoglobin,...., was observed in subjects carrying the βE-globin gene. The mean (± SD) hemoglobin levels of the subject with heterozygous and homozygous state of HbE was 10.9 ± 0.95 and 9.7 ± 0.64 g/dL, respectively, against 11.28 ± 1.42 g/dL observed in normal hemoglobin pattern (Hb AA)".

These results clearly stated that amenia may be a genetic preposition-related disease that can be reversed in some people.


Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries.

With an aim to find a natural ingredient or whole food for the treatment of anemia, with no side effect, researchers at the Covenant University, examined the papaya anti-anemia effect in subjects with sickle cell disease (SCD)

Sickle cell disease (SCD)is a genetic disease caused by an individual inheriting an allele for sickle cell hemoglobin from both parents. The disease is associated with the unusual production of a large number of immature blood cells.

Application of Carica papaya seed oil (Cari-oil) showed significant effects in reducing the levels of sickle blood cells compared with that of untreated SCD patients.


RBCs in Cari-oil treated samples were significantly higher (P < 0.05) compared with VerMyg, antisickling plant-treated samples.

The Cari-oil extract significantly reduced (P < 0.05) lactate dehydrogenase activity, in both in male (HbSSM) and female (HbSSF) human sickle cell blood.

Lactate dehydrogenase activity, LDH consistently increased in patients with anemia.
Furthermore, Cari-oil treated HbSSM and HbSSF blood had significantly increased (P < 0.05) peroxidase activity which was a significant decrease in patients with anemia, compared with controls.

Dr. the lead scientist suggested at the end of the experiment, "Methanolic extracts from... C. papaya seed oil exhibited antisickling properties coupled with the potential to reduce stress in sickle cell patients".


Moreover, in patients with beta-thalassemia major and intermedia and E-beta-thalassemia, researchers found that by ameliorating oxidative stress in red blood cells, the disease may be treatable.

In vitro and in vivo, oral administration of FPP to beta-thalassemia mice (50 mg/mouse/day for 3 months) and to patients (3 g x 3 times/day for 3 months), reduced all the above-mentioned parameters of oxidative stress (p < 0.001 in mice and p < 0.005 inpatients).

The results suggested that FPP, as a potent antioxidant, might alleviate symptoms associated with oxidative stress in severe forms of thalassemia.

In human studies, injection of fermented papaya preparation (FPP) on two groups of beta-thal patients: beta-thal, major and intermedia, (in Israel) and E-beta-thal (in Singapore) increased the production of antioxidant enzymes produced by the host and significantly decreased the levels of ROS.

In other words, fermented papaya preparation (FPP) increased the content of reduced glutathione (GSH) in red blood cells (RBC), and decreased their reactive oxygen species (ROS) generation, membrane lipid peroxidation, and externalization of phosphatidylserine (PS), indicating amelioration of their oxidative status, without a significant change in the hematological parameters.

The finding in human studies indicated it is possible that a longer duration of treatment, probably with the addition of an iron chelator, is required in order to achieve a significant change in the hematological parameters.

Taken altogether, Papaya, particularly in fermentation, may be considered functional for the prevention and treatment of anemia with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Solenostemon monostachyus, Ipomoea involucrata and Carica papayaseed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease by Afolabi IS1, Osikoya IO, Fajimi OD, Usoro PI, Ogunleye DO, Bisi-Adeniyi T, Adeyemi AO, Adekeye BT. (PubMed)
(2) Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation by Fibach E1, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA. (PubMed)
(3) Fermented papayapreparation as redox regulator in blood cells of beta-thalassemic mice and patients by Amer J1, Goldfarb A, Rachmilewitz EA, Fibach E(PubMed)
(4) Preliminary in vitro antisickilng properties of crude juice extracts of Persia Americana, Citrus sinensis, Carica papaya and Ciklavit® by Iweala EE1, Uhegbu FO, Ogu GN.(PubMed)

Dandelion (Taraxacum officinale) Processes Diuretic Property

By Kyle J. Norton

The diuretic effect is the activity of substances that promote urinary secretion.

Diuretics medicines are used for the treatment of water retention or edema by removing fluids from the body.

Water retention or edema is a condition of excess fluids that build up inside your body, including the circulatory system or within tissues and cavities. 

Edema can cause swelling in the hands, feet, ankles, and legs.

Many diuretics medicine can interfere with the functioning kidney in the regulation of the levels of water in the body, leading to worsening kidney function and abnormal electrolyte levels.

Certain medications that treat conditions of high blood pressure, glaucoma, and edema can damage kidney function by overworking the kidney in water release.

Dr. Yusra Habib Khan, the lead author in the study "Chronic Kidney Disease, Fluid Overload and Diuretics: A Complicated Triangle" said, "The use of diuretics was associated with adverse renal outcomes indicated by a decline in eGFR (Glomerular filtration rate (GFR) is a measure of the function of the kidneys) and increased risk of (renal replacement therapy) RRT initiation in our cohort of NDD-CKD patients".

Therefore, the intake of medicine that has a negative effect on kidney function and diuretics medicine should be taken with extreme care.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the improvement of edema, scientists examined the dandelion diuretic effect in 17 individuals.

Participants who entered the study have a volume of urinary output and fluid intake recorded that were established 2 days prior to dandelion dosing (8 mL TID) and monitored throughout a 1-day dosing period and 24 hours postdosing.

According to the records returned by the participants, all populations showed a significant increase in the frequency of urination in the 5-hour period after the first dose.

Furthermore, a significant increase in the excretion ratio in the 5-hour period after the second dose of the extract was also reported by the participants.

However, there was no change in the measured parameters at the third dose.

Based on the evidence, researchers said, "T. Officinale ethanolic extract shows promise as a diuretic in humans. Further studies are needed to establish the value of this herb for the induction of diuresis in human subjects".

Taken altogether, dandelion may be considered a diuretic remedy, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day by Clare BA1, Conroy RS, Spelman K. (PubMed)
(2) Chronic Kidney Disease, Fluid Overload, and Diuretics: A Complicated Triangle by Yusra Habib Khan,1,2,* Azmi Sarriff,1 Azreen Syazril Adnan,2,* Amer Hayat Khan,1 andTauqeer Hussain Mallhi. (PMC)

Dandelion (Taraxacum officinale) Processes Anti-Inflammatory Activity

By Kyle J. Norton

Inflammation is a natural response of the immune system in which the white blood cells of the first line of defense try to protect the body by destroying the foreign pathogens which try to enter the body through wound or tissue damage.

Inflammatory cytokines induce the Inflammatory processes in the body, triggered by the body's own immune system.

During the acute phase of infection, overproduction of proinflammatory cytokines may cause damage to nearby healthy cells, leading to the formation of scars.

Most cases of infection are stopped at the acute phase of infection as the immune system successfully kills off all invaders in a brief battle.

Some researchers suggested the immune system has evolved to protect our body over thousands of years with an aim to kill off all pathogens within a period in the range of 3 to 8 weeks. Otherwise, it will adapt to the new change, leading to chronic inflammation.

In other words, chronic inflammation happens when the immune response lingers, causing low-grade inflammation. Chronic inflammation over time may damage the body tissues and organs.

In some cases, the infection may be latent in which the pathogen remains within the body for a long time without producing any symptoms, such as the hepatitis virus.

Diseases associated with chronic inflammation include cancer, heart disease, rheumatoid arthritis, type 2 diabetes, and obesity.

Anti-inflammatory activity is the use of a substance or treatment for the treatment of od inflammation or swelling.

Anti-inflammatory protein in the body displays anti-inflammatory properties against the risk of autoimmune diseases and immune pathologies such as rheumatoid arthritis, psoriasis, or organ rejection.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined the anti-inflammatory activity of taraxacum officinale (TO) filtered methanol extracts in LPS-stimulated human umbilical vein endothelial cells (HUVECs).

According to the results from the assays on HUVECs pretreated with 100 μg/ml TO for 1 h and then incubated with 1 μg/ml LPS for 24 h, TO filtered methanol extracts dramatically inhibited LPS-induced endothelial cell-monocyte interactions by reducing vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1 associated with cellular inflammation found in various immunological disorders, including rheumatoid arthritis, asthma, transplant rejection.

Furthermore, TO filtered methanol extracts also inhibited the production of pro-inflammatory proteins found in inflammatory subjects.

In other words, TO suppressed the LPS-induced nuclear translocation of NF-κB, without affecting the pro-inflammatory cytokine MAPK activation.

Based on the results, researchers said, "Our findings demonstrated that methanol extracts of TO could attenuate LPS-induced endothelial cell activation by inhibiting the NF-κB pathway. These results indicate the potential clinical benefits and applications of TO for the prevention of vascular inflammation and atherosclerosis".

Taken altogether, dandelion may be considered a remedy for the treatment of diseases associated with chronic inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of Dandelion Extract on the Proliferation of Rat Skeletal Muscle Cells and the Inhibition of a Lipopolysaccharide-Induced Inflammatory Reaction by Liu Q1, Zhao H2, Gao Y1, Meng Y1, Zhao XX1, Pan SN. (PubMed)
(2) Anti-inflammatory evaluation of the methanolic extract of Taraxacum officinale in LPS-stimulated human umbilical vein endothelial cells by Jeon D1,2, Kim SJ3, Kim HS. (PubMed)

Healthy Food Broccoli's Sulforaphane Gobbles Up Gastric Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.

The stomach formed part of the digestive system located between the esophagus and the small intestine, is a muscular, hollow and an important organ of the digestive tract.

The stomach plays a critical role to assist the digestive system in digesting foods by secreting acid and enzymes.

Stomach cancer is a condition of abnormal growth of the mucus-producing cells in the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

According to the statistics, most cases of gastric/stomach cancer are found in older people. The average age of people when they are diagnosed is 68. The risk of developing gastric/stomach cancer in a man lifetime is about 1 in 95.

The exact causes of gastric/stomach cancer are unidentified. However, researchers do no certain risk factors are associated with an increased risk of the disease.

Some researchers suggested that people with chronic gastrointestinal reflux disease (GERD), a condition caused by the frequent backflow of stomach acid into the esophagus, is the most likely to develop the disease.

Other diseases associated with the early onset of gastric cancer are obesity and smoking.

According to the Universidad de Salamanca, bacteria and viruses, including Helicobacter pylori are strongly associated with chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential phytochemical for the treatment of cancer, researchers examined the inhibitory effect of sulforaphane (SFN), the major component extracted from broccoli/broccoli sprouts on gastric cancer.

According to the tested analysis, in vitro, the tumorsphere formation associated with tumor progression and recurrence and the expression levels of gastric cancer stem cells (CSCs) markers were significantly decreased by the SFN treatment.

Furthermore, SFN exerted strong inhibitory effects by suppressing proliferation and inducing apoptosis in gastric CSCs.

Moreover, SFN inhibited the activation of Sonic Hh, a key pathway in maintaining the stemness of gastric CSCs.

Based on the findings, researchers said, "these data revealed that SFN could be a potent natural compound targeting gastric CSCs via suppression of Sonic Hh pathway, which might be a promising agent for gastric cancer intervention".

Taken altogether, broccoli processed a high amount of SFN may be considered a functional food for the prevention and treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway by Ge M1, Zhang L1, Cao L1, Xie C2, Li X2, Li Y2, Meng Y2, Chen Y2, Wang X2, Chen J2, Zhang Q2, Shao J1, Zhong C. (PubMed)

Beta-Sitosterol, the Potential Anti Multiple Myeloma Supplement

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth that starts in the tissue of specific organs.

Most cases of cancer overtime after penetrating into deeper layers of the affected organs, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Pre-cancer is a medical condition that likely develops into cancer if untreated.

Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition and the most common plasma cell disorder.

In other words, monoclonal myeloma gammopathies is a precancerous condition that may cause myeloma, a cancer of white blood cell disorder.

Multiple myelomas (Myeloma) is a type of cancer originated from plasma cells in the bone marrow that produces the white blood cells which are normally responsible for the production of antibodies to protect our body against infection.

Over time, multiple myeloma can lead to the accumulation of cancer cells in the bone marrow, overcrowding out healthy blood cells.

According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).

Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.

The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of cancer, researchers examined the anti-cancer effects of beta-sitosterol (BS), a plant-derived sterol on multiple myeloma U266 cells.

According to the experimental analysis, Beta-sitosterol induced cytotoxicity increased sub-G1 apoptotic population and activated caspase associated with the pro-apoptotic activity and blocked the cancer cell in the energetic converting process in U266 cells.

Furthermore, Beta-sitosterol promoted ROS expression by activating the enzymes involved in free radical production in U266 cells. 

Moreover, beta-sitosterol attenuated the induction of new blood vessels by the cancer cells to promote proliferation and suppressed pathways associated with suppression of cancer cell apoptosis and tumor progression.

Additionally, beta-sitosterol also suppressed the proteins associated with DNA repair. sub-G1 accumulation, proliferation, and pro-oncogenic function in U266 cells.

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention and treatment of multiple myeloma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells by Sook SH1, Lee HJ, Kim JH, Sohn EJ, Jung JH, Kim B, Kim JH, Jeong SJ, Kim SH. (PubMed)

Omega 3 Fatty Acids May Be a Potent Anti Cancer Remedy

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite, and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.
The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Believe it or not, 1/4 of cancers death are due to lung cancer.

Depending on types of cancer, people with cancers may experience general and specific symptoms.

The American Cancer Society wrote, "Cancer may also cause symptoms like fever, extreme tiredness (fatigue), or weight loss. Because cancer cells use up much of the body’s energy supply, or they may release substances that change the way the body makes energy from food. Cancer can also cause the immune system to react in ways that produce these signs and symptoms" and " Sometimes, cancer cells release substances into the bloodstream that cause symptoms that are not usually linked to cancer. For example, some cancers of the pancreas can release substances that cause blood clots in veins of the legs".

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of invasive tumors, researchers examined the Omega 3 fatty acid therapeutic role against certain types of cancer.

According to the results from differentiation, omega-3 FAs showed a strong improvement in chemo drug effects and tolerability.

Furthermore, the application of omega 3 fatty acids suppressed the protein and pathway associated with cell division and apoptosis and modulated the factors involved in free radical production.

Moreover, omega 3 fatty acids enhanced the activity of novel anti-inflammatory lipid mediators against the production of pro-inflammatory cytokines to induce cell DNA damage.

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of cancers, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials by Nabavi SF1, Bilotto S2, Russo GL3, Orhan IE4, Habtemariam S5, Daglia M6, Devi KP7, Loizzo MR8, Tundis R8, Nabavi SM. (PubMed)

Tocopherols Protect the Electrical Activity in the Brain Against Seizure

By Kyle J. Norton

Epilepsy is a condition of a neurological disorder caused by abnormal electrical activity in the brain inducing sudden recurrent episodes of sensory disturbance and convulsions.

Anticonvulsant is a function to control seizures (convulsions) or stop an ongoing series of seizures.

A seizure is a sudden, abnormal electrical disturbance in the brain. Epidemiological studies suggested seizures can change in behavior, movements or feelings, and in levels of consciousness.

The hormone melatonin is approved only for the treatment of jet-lag syndrome and some types of insomnia, clinical data also suggest that it is effective in the adjunctive therapy of osteoporosis, cataract, sepsis, neurodegenerative diseases, hypertension, and even cancer. 

 In humans, melatonin may attenuate seizures, and it is most effective in the treatment of juvenile intractable epilepsy. 

Its additional benefits include improved physical, emotional, cognitive, and social functions. On the other hand, melatonin has been shown to induce electroencephalographic abnormalities in patients with temporal lobe epilepsy and increase seizure activity in neurologically disabled children. 

The hormone showed very low toxicity in clinical practice, according to the study by the Department of Pathophysiology, Medical University, PL 20-090 Lublin, Jaczewskiego 8, Poland(22).

The most common symptoms of seizure, signs, and symptoms can range from mild to severe and vary depending on the type of seizure, according to the Mayo clinic, including
* Temporary confusion

* A staring spell

* Uncontrollable jerking movements of the arms and legs

* Loss of consciousness or awareness

* Cognitive or emotional symptoms, such as fear, anxiety or deja vu

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of epilepsy, researchers examined the
inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats.

According to the results of ascorbic acid (250 or 500 mg/kg, i.p.) and alpha-tocopherol (200 or 400 mg/kg, i.p.) on the behavior and brain lesions on seizures induced by pilocarpine (400 mg/kg, i.p., P400 model), Ascorbic acid or alpha-tocopherol injections prior to pilocarpine suppressed behavioral seizure episodes.

Furthermore, the antioxidant administration inhibited free radicals that cause brain damage induced by seizures.

In the P400 model, ascorbic acid and alpha-tocopherol significantly decreased cerebral damage percentage. 

More precisely, antioxidant compounds can exert neuroprotective effects associated with the inhibition of free radical production.

 Based on the results, researchers said, " These results highlighted the promising therapeutic potential of ascorbic acid and alpha-tocopherol in treatments for neurodegenerative diseases".

Taken altogether, tocopherols may be considered a supplement for prevention and treatment of seizure, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory action of antioxidants (ascorbic acid or alpha-tocopherol) on seizures and brain damage induced by pilocarpine in rats by Tomé Ada R1, Ferreira PM, Freitas RM. (PubMed)
(2) The Effects of Hormone Melatonin (N-acetyl-5-methoxytryptamine) (3) by Kyle J. Norton

Fennel Normalizes Blood Cholesterol in Vivo and Human Study With No Side Effects, Researchers Say

By Kyle J. Norton

Scientists may have found a natural whole food with the potential to treat hyperlipidemia without inducing any side effects, some studies suggested.

Cholesterol, the natural ingredient produced in the liver plays an important role in stimulating the production of vitamin D, steroid hormones, and bile acids and maintaining healthy cell membranes.
Hyperlipidemia is a condition characterized by abnormally elevated levels of cholesterol in the plasma of the blood.

The causes of hyperlipidemia are unknown. However, an unhealthy diet with a lot of unsaturated fat and trans fat is associated with the early onset of the disease. Foods such as cheese egg yolks fried and processed foods and red meat have found to increase blood cholesterol, long-term intake of such foods in great amount have been found to increase the risk of hyperlipidemia, epidemiological studies found.

The Beni-Suef University, in the study to determine the development of obesity in response to a high-fat diet (HFD) an Egyptian Herbal mixture formulation (HMF), including fennel, showed, "feeding HFD diet significantly increased final body weight, triglycerides (TG), total cholesterol, & LDL concentration compared with controls, while significantly decreasing HD".

Hyperlipidemia is a lifelong condition that is treatable.

Dr. Robert B. Kelly at the Fairview Hospital/Cleveland Clinic Family Medicine Residency Program in the article "The most beneficial changes result from reducing intake of saturated and trans fats; increasing intake of polyunsaturated and monounsaturated fats; fortifying foods with plant stanols or sterols; isocalorically adding tree nuts to the diet; consuming one or two alcoholic drinks per day; and adopting a Portfolio, Mediterranean, low-carbohydrate, or low-fat diet. Smaller but still beneficial effects result from reducing intake of dietary cholesterol, increasing intake of soluble fiber and soy protein, and eating fatty marine fish or taking marine-derived omega-3 fatty acid supplements".
Therefore by changing the diet pattern and engaging in regular physical exercise are the fundamental
options that not only can prevent the onset of the condition, particularly in people who are at a higher risk of hyperlipidemia, and also treat high blood cholesterol in patients who already have the condition.


Fennel (Foeniculum vulgare) is a plant species of a genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The plant has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS.

In the study to examine the effect of the aqueous extract of fennel in the reduced risk of hyperlipidemia, researchers conducted an experiment in Triton WR-1339 induced hyperlipidemia in mice.

Mice treated with the extract at different doses display a significant reduction of cholesterol, triglycerides, LDL-cholesterol, and apolipoprotein-B decreased by 40%, 23%, 61%, and 61%, respectively.

Further analysis, the application also increased the levels of HDL-cholesterol and apolipoprotein A1 by 85% and 58%, respectively

Also according to the Mashhad University of Medical Sciences which also conducted a study to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles, in sixty eligible postmenopausal women, randomly assigned into the fennel and placebo groups.

Measurement of total blood cholesterol, cholesterol fractions, and triglycerides was tested at the baseline, and after a three-month follow-up.

At the end of 3 months, blood profiled withdrawn from the women suggested
* There are no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol(LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups.

* Fennel treated group demonstrates a significant borderline improvement for HDL-C and triglyceride, compared to the placebo group.

Additional differentiation of the process of the double-blind, randomized, and placebo-controlled trial, researchers suggested that longer durations, higher doses, and larger sample sizes are recommended to validate the results.


These results indicated that intake of foods for the treatment of conditions or diseases must be on a long-term basis. The times of 3 months may be too short for foods to exert their potential effects.


Taken all together, fennel may be considered a functional food for the prevention and treatment of hyperlipidemia. Intake of fennel should be increased gradually for the food to reach its antihyperlipidemic stage, a longer duration may be needed. In other words, please be patient.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial by Afiat M1, Amini E2, Ghazanfarpour M3, Nouri B4, Mousavi MS5, Babakhanian M6, Rakhshandeh H(PubMed)
(3) Effect of Carnitine and herbal mixture extract on obesity induced by high-fat diet in rats by Amin KA1, Nagy M(PubMed)

Beta-Sitosterol Reduces the Risk of Non-Alcoholic Fatty Liver Disease

By Kyle J. Norton

The liver is the largest internal organ with a function which filters the blood from the intestinal tract before passing them to the heart and other parts of the body.

Additionally, the liver also produces bile to aid digestion and cholesterol to build strong cell membranes, production of vitamin D and steroid hormones.

Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.

Nonalcoholic liver disease is a chronic condition caused by fat accumulated over time in the liver, affecting people who drink little to no alcohol.

In other words, if you have fat that makes up over 5% of the liver, you are considered to have fatty liver disease.

Nonalcoholic liver disease can be classified into the noninflammatory fatty liver and inflammatory liver steatohepatitis.

Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer.

According to world statistics, nonalcoholic fatty liver disease (NAFLD) is normally known as a disease of the Western world(2). However, due to the economic prosperity of Southeast Asian(3), the disease also was found in a large population in the cities, causing concerns of many scientists in the region(4)(6).

According to the joint assessment of the prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the US, led by the Stanford University School of Medicine, "The prevalence of NAFLD in the United States (U.S.) has risen from 18% in 1988–1991 to 31% in 2011–2012. Estimates of NAFLD prevalence for adults in Western countries are 20–30%, with much higher prevalence in adults with obesity (80–90%), diabetes (30–50%), and hyperlipidemia (90%)"(5).

Among the more affluent regions of China, the prevalence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 15%(6). The number may decrease substantially if the poor rural populations where obesity is non-existence are also taking into account(7).

The most common complications of NAFLD are 

*  increased mortality and increased cancer risk, particularly liver cancer, among patients discharged with a diagnosis of alcoholic fatty liver.

* increased progression of cirrhosis, accompanied by complications that include variceal bleeding, ascites, encephalopathy, and liver failure.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the potential protective effects against NAFLD in growing rats fed a high-fructose diet, modeling children fed obesogenic diets.

The study included Forty-four 21-day old male rat pups randomly allocated to and administered the following treatments for 12 weeks:
* Group I- standard rat chow (SRC) + plain drinking water (PW) + plain gelatine cube (PC); 

* Group II- SRC+ 20% w/v fructose solution (FS) as drinking fluid + PC;

* Group III- SRC + FS + 100 mg/kg fenofibrate in gelatine cube; and

* Group IV- SRC + FS + 20 mg/kg β-sitosterol gelatine cube (Bst) and group V- SRC + PW + Bst.

According to the chemical analysis, rats treated with high-fructose diet caused the increased (p<0.05) hepatic lipid (total) accretion (>10% liver mass), micro- and macro-vesicular hepatic steatosis and hepatic inflammation.

In other words, a high-fructose diet in vivo increased the risk of NAFLD and possibly initiated the onset of NAFLD.

β-sitosterol and fenofibrate treatment restore the liver integrity by inhibiting the high-fructose diet-induced macrovesicular steatosis and prevented the progression of NAFLD to steatohepatitis.

Moreover, β-sitosterol was also found to mitigate diet-induced NAFLD.

Taken altogether, beta-sitosterol may be considered a supplement for the prevention and treatment of NAFLD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) β-sitosterol mitigates the progression of high-fructose diet-induced non-alcoholic fatty liver disease in growing male Sprague-Dawley rats by Gumede N1, Lembede B2, Nkomozepi P3, Brooksbank R4, Erlwanger KH5, Chivandi E. (PubMed)
(2) Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet by Feng S1, Dai Z2, Liu AB3, Huang J4, Narsipur N3, Guo G5, Kong B5, Reuhl K5, Lu W6, Luo Z7, Yang CS. (PubMed)

Phytochemical Sinigrin Found in Brussels Sprout, and Broccoli Processes Anti-Chronic Inflammatory Diseases Property, According to Research

By Kyle J. Norton

Sinigrin may be used as a natural and bioactive compound against diseases associated with chronic inflammation, according to studies.

Acute inflammation that lasts a day or 2 mostly associated with proinflammatory response to tissue injury, usually appearing within minutes or hours, depending on the severity of the damage.

In other words, in the acute phase of inflammation, the immune system response of the macrophages stimulates the process of coagulation to cover the wound or injure and production of the inflammatory cytokines to destroy the foreign pathogens which try to enter the body through the wound or injury.

The most common symptoms of acute inflammation are pain, redness, loss of function, swelling, and heat.

In the acute phase of inflammation, overproduction of proinflammatory cytokines which protect our body against foreign invasion may damage the nearby tissues and death of the healthy cell, leading to the abnormal formation of scars.

Chronic inflammation is a medical condition caused by the inability of the immune system to kill off all pathogens in the acute phase of inflammation, leading to the compromise of the immune system.

Chronic inflammation is a leading cause of various types of disease, including cancer, diabetes, cardiovascular disease, and arthritis.

Unlike the symptoms of acute inflammation, symptoms of chronic inflammation are totally depending on the types of disease and location of the inflammation, including fatigue and unintended weight loss and loss of appetite in cancer, chest pain in chronic lung disease, and joint pain in RA.

On finding a natural compound for the treatment of diseases associated with chronic inflammation, researchers investigated the effect of sinigrin on macrophage function.

In RAW 264.7 cells in a concentration-dependent manner, sinigrin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory cytokines including nitric oxide (NO) and the expression of COX-2 and prostaglandin E2 (PGE2).

Injection of sinigrin significantly suppressed the production of pro-inflammatory tumor necrosis factor (TNF)-α and interleukin (IL)-6 by suppressing the protein in the cellular response to oxidative stress and stimuli.

Additional analysis, sinigrin also processed a significant effect in inhibiting genes expression involved in the mediation of innate immunity and inflammatory responses.


Dr. Lee HW, the lead scientist, wrote in the final report, " Our findings also provide evidence that the pharmacological modulation of sinigrin could have an anti-inflammatory effect".

In lipopolysaccharide (LPS)-induced neuroinflammation, AITC protected the microglial cells against neuroinflammation by inhibiting the cellular response against oxidative stress-induced the production of pro-inflammatory cytokines such as cyclooxygenase-2 (COX-2) expression, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E2 (PGE2).

In other words, AITC protects neuroblastoma cells by controlling with JNK/NF-κB/TNF-α cross-linking associated with the expression of the gene in inducing apoptosis.

Dr. Subedi L, the lead scientist, after taking into account co and confounders said, "These findings provide novel insights into the anti-neuroinflammatory effects of AITC on microglial cells, which may have clinical significance in neurodegeneration".

Taken altogether, sinigrin may be considered a functional supplement for the prevention and treatment of diseases associated with chronic inflammation, pending the confirmation of a large sample size and multicenter human study.

However, intake of bioactive in the form of supplements should be taken with extreme care, as liver toxicity may be induced if overdosed.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin inhibits the production of inflammatory mediators by suppressing NF-κB/MAPK pathways or NLRP3 inflammasome activation in macrophages by Lee HW1, Lee CG1, Rhee DK1, Um SH2, Pyo S. (PubMed)
(2) Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling by Subedi L1, Venkatesan R2, Kim SY. (PubMed)