Kyle J. Norton
Skin, a large organ that forms the out layers of our body has serval layers of ectodermal tissue that protect the underlying muscles, bones, ligaments, and internal organs against foreign pathogenic invasion. Skin cancer is a medical condition characterized by disordered and irregular cell growth in the skin.
Most cases of primary skin cancer start in the cell on the surface of the inner ling of the skin. At the advanced stage, the cancerous cells can travel a distance away from the skin to infect other healthy tissue and organ through blood and fluid circulation.
Melanoma is a kind of skin cancer but less common than other skin cancer as a result of the malignancy of melanocytes, which is the cell-produced dark pigment for your skin.
Approximately 120,000 new cases of melanoma in the US are diagnosed in a year. melanoma tends to spread along the skin in most cases but also can grow down to the deeper layers of the skin. At the later stage, it can spread to distant parts of the body, including organs.
Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin. However, at a later stage, the cancer cells can travel through the circulation of blood and fluids to infect other healthy cells and tissue, leading to secondary metastasis.
The liver, lungs, bones, and brain are most often affected by melanoma metastases.
According to statistics, the risk of melanoma is largely dependent on race. The lifetime risk of getting melanoma is about 2.5% (1 in 40) for whites, 0.1% (1 in 1,000) for blacks, and 0.5% (1 in 200) for Hispanics.
The 5 years survival rate of melanoma is close to 100% if the disease is diagnosed in the localized stages.
In the US, every year, approximately 96,480 new melanomas are diagnosed, leading to the death of 7,000 people.
In North America, most cases of melanoma are associated with UVB exposure, causing the alteration of the cell DNA.
Nonmelanoma skin cancer is a type of skin cancer involved in basal cell carcinoma and squamous cell carcinoma.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
In finding a potential phytochemical for the treatment of cancer, researchers examined the role of omega-3 FA in the prevention of non-melanoma skin cancer (NMSC).
According to the results of the analysis* Dietary omega-3 FA dramatically reduces the plasma and cutaneous pro-inflammatory and immunosuppressive PGE(2) levels in vivo, compared to dietary omega-6 FA in the increase of prostaglandin E synthase type 2 (PGE(2)) level.
* Dietary omega-3 FA significantly reduces the inflammatory response and sustains, or enhances, the delayed-type hypersensitivity immune response in mice when compared to an equivalent dietary level of omega-6 FA.
* Supplementary omega-3 FA significantly increases the UVR-mediated erythema threshold in humans.
Furthermore, supplementary omega-3 FA significantly reduces the level of pro-inflammatory and immunosuppressive PGE(2) levels in Ultraviolet B-irradiated human skin.
In other words, omega-3 FA showed a strong implication on the immune response in the induction of pro-inflammatory cytokines induced the risk of non-melanoma skin cancer (NMSC).
Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of skin cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose and acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The potential of omega-3 fatty acids in the prevention of non-melanoma skin cancer by Black HS1, Rhodes LE. (PubMed)
(2) Potential Benefits of Omega-3 Fatty Acids in Non-Melanoma Skin Cancer by Black HS1, Rhodes LE. (PubMed)
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