Saturday, 22 July 2023

#ManukaHoney Inhibits the Proinflammatory Cytokines and Mast Cell Degranulation Associated with #AtopicDermatitis, Researchers Reveal

Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have found a herbal remedy for the prevention and treatment of atopic dermatitis, according to studies.

Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.

Most cases of atopic dermatitis are found in children. However, adults may also get it too. Skin irritation is found more often in children compared to adults.


The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environmental conditions may be involved in the development of the disease.


Epidemiological studies suggested that most patients with chronic atopic dermatitis also have asthma and hay fever, particularly in allergies.

Some researchers suggested that atopic dermatitis is more common in people who live in the air pollution city.

Dr. Ahn K in the study of the role of air pollutants in atopic dermatitis, wrote, " Both indoor and outdoor air pollution, which are of increasing concern with urbanization, are well-known environmental risk factors for asthma, whereas there is relatively little evidence in AD".


And, " epidemiologic and experimental data on the role of air pollution in patients with AD. Recent evidence suggests that a variety of air pollutants, such as environmental tobacco smoke, volatile organic compounds, formaldehyde, toluene, nitrogen dioxide, and particulate matter, act as risk factors for the development or aggravation of AD. These air pollutants probably induce oxidative stress in the skin, leading to skin barrier dysfunction or immune dysregulation".

The results clearly suggested the risk of atopic dermatitis increases with air pollutants.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers in the course to find a natural ingredient for the treatment of dermatitis examined the Manuka honey anti-skin conditions and dermal injuries.
Injection of Manuka honey showed a significant potency in the treatment of a severe atopic contact dermatitis eczematous reaction with no side effects.

Furthermore, adult volunteers with bilateral atopic dermatitis (AD) were asked to apply MH on one site overnight for seven consecutive days and leave the contralateral site untreated as possible.

There are no significant changes in the skin staphylococci observed after day 7, irrespective of honey treatment.

However, MH treatment showed significant inhibition of proinflammatory cytokines in a dose-dependent manner.

The application of MK also inhibited mast cell degranulation against the onset of atopic dermatitis (AD).

Dr. Alangari AA, the lead scientist said in the final report, "MH is potentially effective in the treatment of AD lesions based on both clinical and cellular studies through different mechanisms".

Taken altogether, Manuka honey may be considered a functional remedy for the prevention and treatment of atopic dermatitis (AD) with no side effects, pending the confirmation of a larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Manuka Honey: A Case Study of Severe Atopic Eczematous Dermatitis Reaction to Henna Tattoo by Harrison J. (PubMed)
(2) Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies by Alangari AA1, Morris K2, Lwaleed BA3, Lau L4, Jones K2, Cooper R2, Jenkins R. (PubMed)
(3) The role of air pollutants in atopic dermatitis by Ahn K. (PubMed)

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