The liver is a large organ in the human body that processes a number of functions, including producing bile to aid digestion, detoxifying metabolites, synthesizing proteins, and filtering blood from the digestive tract before passing them to other parts of the body.
Symptoms of liver toxicity include gastrointestinal discomforts such as nausea, vomiting, and jaundice. Some patients with liver toxicity also experience the symptom of right upper quadrant abdominal pain.
If you have some of the aforementioned symptoms, please check with your doctor immediately. Acute liver toxicity may be life-threatening.
The most common causes of liver toxicity in the Western world are excessive alcohol drinking and long-term use of certain medications and overdoses of herbal supplements.
Dr. Victor Navarro, M.D. in the examination of the herbal and dietary supplements in risk liver toxicity wrote, "Herbal and dietary supplements (HDS) -induced liver injury now accounts for 20% of cases of hepatotoxicity in the United States based on research data".
And, "The major implicated agents include anabolic steroids, green tea extract, and multi-ingredient nutritional supplements (MINS)".
The results strongly suggested if you are currently using some of the herbal and dietary supplements, please make sure that you follow the direction and guidelines set out in the products to prevent unnecessary live toxicity.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener.
On finding the natural and potential ingredient for the prevention of liver toxicity, researchers investigated honey's protective effect against toxic materials.
The study included 24 male rabbits allocated into four groups six rabbits each given daily during 24 days of experimentation; group 1: the control group, received distilled water (0.1 ml/kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral honey (1 g/kg.b.wt/daily).
Injection of the lead group induced hepatic injury and caused anemia during three weeks of exposure.
Treatment with honey in the lead group not only prevented liver lead toxicity but also ameliorated lead-induced anemia.
The results clearly suggested that honey has a protective effect against lead-induced blood, hepatic, and toxic effects.
Furthermore, in order to reveal more information about honey liver protective activity, researchers examined the Manuka and Talh honey against cisplatin (CISP)-induced hepatotoxicity in a rat model.
Before the injection of Manuka and Talh honey, rats treated with CISP-induced liver dysfunction were observed with liver toxicity.
Administration of Manuka honey prevented CISP-induced histopathological changes observed in the rat liver but not in the kidney.
Manuka and Talh honey also reduced oxidative stress in the liver by stimulating the production of antioxidant enzymes from the treated rats.
In other words, both jars of honey inhibited the expression of proinflammatory cytokines including COX-2 and NF-κB by the cisplatin (CISP)-induced hepatotoxicity.
Taken altogether, honey, particularly Manuka and Talh honey may be considered function remedies for the prevention and treatment of liver toxicity, pending to the validation of a larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-κB-mediated COX-2 expression and the oxidative stress-dependent BAX/Bcl-2/caspase-3 apoptotic pathway by Neamatallah T 1, El-Shitany NA, Abbas AT, Ali SS, Eid BG. (PubMed)
(2) Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity by Fihri AF1, Al-Waili NS, El-Haskoury R, Bakour M, Amarti A, Ansari MJ, Lyoussi B. (PubMed)
(3) Liver Injury from Herbal and Dietary Supplements by Victor Navarro, M.D.,1 Ikhlas Khan, Ph.D.,2 Einar Björnsson, M.D., Ph.D.,3 Leonard B. Seeff, M.D.,1 Jose Serrano, M.D., Ph.D.,4 and Jay H. Hoofnagle, M.D.(PMC)
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