Honey may be a potential natural source for the pharmaceutic target for the finding of anti-prostate cancer single and synthetic medicine, some studies suggested.
Prostate cancer is low growth and progression medical and chronic disease caused by cell growth disorderly and irregularly in the prostate tissue.
Most cases of primary prostate cancer start in the cells on the surface of the prostate's inner lining tissue. Most people with the early stage of prostate cancer may not have any symptoms, however, some may experience the symptom of an enlarged prostate such as pain during urination and urinary difficulty.
Most secondary cancers associated with prostate cancer metastasis are the lymph nodes and the bones.
However, at the advanced stage, the cancerous cells in the prostate can travel a distance away to infect other healthy tissue and organ by way of the lymph system or bloodstream.
Most prostate cancer is diagnosed during the annual physical exam after the enlarged prostate is discovered
Researchers do not the exact cause of prostate cancer. Neither do they know why men in the same family with similar diet patterns, some are susceptible to the prostate cells' DNA alternation, while some do not.
According to the statistic provided by the Australian government, the mortality rate of prostate cancer decreased from 34 deaths per 100,000 males in 1982 to 31 per 100,000.
In 2011. Around 9 in 10 males diagnosed with prostate cancer survive 5 years from diagnosis. Prostate cancer is the fourth leading cause of mortality among Australian males, causing 3,294 deaths.
There are many risk factors associated with the development of prostate cancer. However, An unhealthy diet and lifestyle are the preventable risk factors that cause widespread prostate cancer in the Western world.
Dr. Roberto Fabian, the lead scientist at the University of Perugia, in support that the Western diet is the major cause of prostate cancer, conducted the study "A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis" by searching the database of PubMed, Web of Science to identify studies reporting the relationship between dietary patterns and PC risk.
After taking the account multivariable-adjusted odds ratios (ORs), wrote, " Twelve observational studies were included in the meta-analysis which identified a “Healthy pattern” and a “Western pattern” and "The Healthy pattern was not related to PC risk (OR = 0.96; 95% confidence interval (CI): 0.88–1.04) while the Western pattern significantly increased it (OR = 1.34; 95% CI: 1.08–1.65)".
These comparable results once again suggested that men who follow the Western diet are associated with an increased risk of prostate cancer
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
Honey is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener.
In finding a natural ingredient for the treatment of prostate cancer without inducing any side effects, researchers at the University of Otago looked into honey, the complex biological substance, consisting mainly of sugars, phenolic compounds, and enzymes.
In prostate cancer cells PC3 and DU145, the application of honey whole food exerted a strong inhibitory effect through the expression of cytotoxicity.
The sulforhodamine B assay gave valid anti-prostate cancer results, but measures only protein content, providing no information about cell death in the remaining cells.
The trypan blue assay and a microscope-based propidium iodide/Hoechst staining assay assess only late-stage membrane permeability.
Only the propidium iodide/Hoechst assay provides morphological information about the cell death mechanism.
These results suggested that honey processed a potential to induce prostate cancer cell death through certain known and unknown mechanisms besides those found in the sulforhodamine B and propidium iodide/Hoechst assays
Interestingly, the examine the possibility of New Zealand thyme, manuka, and honeydew honey, and their major sugar and phenolic components, reducing the development of metastatic cancer.also in PC3 and DU145 prostate cancer cell lines. researchers showed that
Non-toxic concentrations of thyme and honeydew honey reduced prostate cancer cell migration by 20% observed by the Boyden chamber-based migration assay,
All phenolic compounds including gallic acid, quercetin, kaempferol, and chrysin except caffeic acid also lowered migration, although a mixture of only the sugars found in honey had no effect.
All of the honey, phenolics, and sugar-only mixture reduced the invasive movement of cells through the extracellular matrix in the cellular division by up to 75%.
Additional analysis also found that each of the three kinds of honey and the sugar-only mixture reduces cell adhesion to collagen I by 90%, with the exception of quercetin.
However, honey and its sugar and phenolic components can lower the metastatic properties of cancer cells and may do this by preventing effective cell adhesion to the extracellular matrix.
Once again, researchers suggested that the sugars and phenol compounds of honey are much more effective in combination than individually.
In other words, the anticancer activity of honey is attributed to all ingredients in the whole food.
Taken together, intake of honey in a moderate amount daily may have a potential effect in the prevention and combined with primary therapy for the treatment of prostate cancer.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Honey is cytotoxic towards prostate cancer cells but interacts with the MTT reagent: Considerations for the choice of cell viability assay by Abel SDA1, Baird SK. (PubMed)
(2) Honey reduces the metastatic characteristics of prostate cancer cell lines by promoting a loss of adhesion by Abel SDA1, Dadhwal S2, Gamble AB2, Baird SK. (PubMed)
(3) A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis by Roberto Fabiani,1,* Liliana Minelli,2 Gaia Bertarelli,3 and Silvia Bacci. (PubMed)
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