Anise may have a potential and substantial effect on the treatment of depression, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic,...
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Depression is a condition of a mood disorder. affecting the patients' feel, think, and handle daily activities.
According to the statistic of The National Institute of Mental Health, approximately, 16 million adults had at least one major depressive episode in 2012 in the United States, 6.9 percent of the population.
In the evaluation of the herbal Anise aqueous and ethanol extracts antidepressant-like effects in mice with several different doses of 50, 100, and 200 mg/kg in compared to the standard medicine Fluoxetine at the dose of 30mg/kg and imipramine at a dose of 20mg/kg, researchers at the joint study lead by the Azad University showed that except for the dose at 50mg/kg of aqueous extract, application of other doses demonstrated a linearly significant improvement of mobility times.
Further analysis also found that all doses from Anise extract increased the swimming time dose-dependently, without any significant change in climbing time in tested mice similar to those of Fluoxetine and in compared to aqueous extract.
Moreover, Fluoxetine and imipramine expressed a strong decreased immobility time in both tests in contrast to imipramine's increased climbing time without any significant change in swimming time.
The result suggested that both extracts in a dose higher than 50mg/kg display antidepressant-like activity similar to that of fluoxetine through improved mobility of depressed mice as inactivity is considered one of the major symptoms in patients with depression.
As the depression progress, patients demonstrated behavior in making efforts to escape from society and eventually will exhibit immobility with the reflection of psychological despair.
Dr. Shahamat Z the lead author said, " P. anisum possesses an antidepressant-like activity similar to that of fluoxetine, which has a potential clinical value for application in the management of depression".
Additionally, in the testing essential (volatile) oil and essential oil of Piper laetispicum antidepressant activity in compared to Fluoxetine as standard antidepressant drug and other natural remedies including Leaves-Bay, Curry, Coriander, and Mint; Fruits-Star anise, Pepper, Cardamom, Caraway and Fennel; Seeds of Fenugreek, Mustard, Nutmeg and Black Cumin; and Underground stem-Onion, Garlic, Ginger and Turmeric; Miscellaneous-Clove, Cinnamon, Capsicum, Tamarind and Asafoetida, researchers found that all participated in essential oil, especially anise produced a significant reduction in immobility along with an increase in climbing behavior similar to those of fluoxetine.
The application of essential oil caused a dose-dependent reduction( probably in a dose less than 50 mg/kg) in immobility which is contracted to the above study and an increase in climbing at all studied doses compared to a control group.
Furthermore, in the examination of the efficacy of anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome a total of 120 were randomly assigned into 3 equal groups received anise oil, Colpermin, and placebo, at the end of the study, scientists showed that application of anise group exerted a continuous improvement of the syndrome compared to the other 2 groups with some unknown mechanisms.
Some researchers postulated that essential oil smell may have a profound effect on the brain in triggering an emotional reaction in stimulating the limbic system in regulated autonomic and endocrine function, particularly, in response to emotional stimuli in the expression of motivation and reinforcing behaviors.
Additionally, the application of essential oil scent also has a direct influence on calming the central nervous system in ameliorating the overproduction of certain hormones in reacting to unfavorably emotional behaviors.
Taken together, Anise essential oil may be used as a secondary therapy to standard medicine in the treatment of depression.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice by Shahamat Z1, Abbasi-Maleki S2, Mohammadi Motamed S3.(PubMed)
(2) The effectiveness of Anise Oil for the Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome. A Randomized Active and Placebo-Controlled Clinical Trial by Maryam Mosaffa-Jahromi, PharmD, Ph.D., Ali-Mohammad Tamaddon, PharmD, Ph.D., Suleiman Afsharypuor, PharmD, Ph.D., Alireza Salehi, MD, MPH, Ph.D., Seyed Hassan Seradj, PharmD, Ph.D., Mehdi Pasalar MD, MPH, Ph.D., Peyman Jafari, Ph.D., Kamran Bagheri Lankarani, MD (Journal of Evidence-Based Integrative Medicine)
(3) Essential oil isolation from culinary drugs and screening for antidepressant potential Mohib Abdul Jalil Khan, Imtiyaz Ansari, Amjad Ali Mohammad Iqbal Oriental College of Pharmacy, Navi Mumbai, Maharashtra- 400705, India. (INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY MEDICINE AND BIOALLIED SCIENCES)
(4) The Forced Swim Test as a Model of Depressive-like Behavior by Roni Yankelevitch-Yahav, 1, 2 Motty Franko, 2 Avrham Huly, 2 and Ravid Doron(PMC)
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