Kyle J. Norton
Detoxification is a natural process in the removal of toxic substances from the human body, mainly carried out by the liver and kidney.
However, prolonged period exposed to toxins may lead to organ failure, causing a disruption of hormone production, damage to other organs, and a weakening immune system.
1. Spinach
Besides being rich in vitamins A, E, and C, minerals such as iron, potassium, magnesium, zinc, and calcium are vital for a healthy heart. it also contains antioxidants, lutein, and beta carotene with the function in strengthen immune defense against the forming of free radicals.
People with kidney disease should not eat spinach, due to high oxalate, without drinking a lot of water or juice intake of spinach may increase the risk of forming kidney stones.
According to the study by the University of Tuscia, spinach exerted detoxifying effect in Chlorosis develops in Spinacia oleracea L. plants against exposure to Cd in the basal leaves through phytochelatin production and the nitrogen and sulfur metabolic pathways as dead leaves detach from the plant, they carry away the sequestered Cd(1).
Furthermore, in the model system Caenorhabditis elegans to investigate the anti-oxidative and anti-aging effects of chlorophyll in vivo, researchers found that the application of chlorophyll isolated from spinach enhances the lifespan of C. elegans by up to 25% via activation of the DAF-16/FOXO-dependent pathway in regulated aging progression through detoxification and antioxidant activities(2).
2. Broccoli
Broccoli is high in vitamin C, an antioxidant with properties in reduced inflammation and inhibited forming of free radicals caused by toxins in our body.
Study shows that some of the chemicals such as indole 3, selenium, and diindolymethane exerted anti-cancer properties by preventing and repairing DNA damaging cells.
According to a study by the Research and Development Division, Kagome Co., Ltd., broccoli sprout extract (BSEx) expressed a significant liver protective effect caused by various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis, on liver gene expression and acute liver injury in the rat(3).
Additionally, 3-methylsuphinylpropyl and 4-methylsulphinylbutyl glucosinolates. isolated from broccoli demonstrated strong activity in an enhanced ability to induce phase 2 detoxification enzymes in mammalian cells(4).
3. Garlic
Garlic is a supernatural food with a proven record of preventing heart diseases, lower cholesterol levels, elevating blood pressure as well as increasing the transportation of oxygen, and stimulating the production of insulin if needed.
Allicin, an antibody isolated from garlic reduced inflammation and fought off degeneration caused by viruses, and bacteria by strengthening our immune system.
The sulfur element processed a rejuvenating property by increasing the function of the liver in removing toxins.
According to Kagoshima University, sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells(5).
Moreover, in the rat model NDEA-induced hepatocarcinogenesis, researchers found that application of garlic oil (GO) inhibited the infectious cells through activated changes of hepatic phase Ⅰ detoxified enzymes (including cytochrome P450 enzyme (CYP) 2E1, CYP1A2 and CYP1A1) and phase Ⅱ detoxified enzymes (including glutathione S transferases (GSTs) and UDP- Glucuronosyltransferases (UGTs))(6).
4. Green tea
Green tea processes the highest antioxidants compared to other foods with the same volume.
In the study, 70 rats were randomly assigned into 4 groups of 10 and studied over 2 months. Group 1: Normal diet and tap water; Group 2: 10 mg/kg intraperitoneal lead acetate weekly over 8 weeks; Group 3: Lead acetate + 100 mg/kg green tea, Group 4: Extract green tea, researchers found that green tea treated group inhibited lead exposure observed by weight change and lowest sperm abnormalities in compared to lead group with no treatment(7).
In redox-sensitive transcription factor, nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2) aspects, application of green tea EGCG, exhibited chemoprevention and cytoprotection in modulated Nrf2-mediated cellular events through its ability in regulated the expression of antioxidant proteins to protect against oxidative damage triggered by injury and inflammation(8).
5. Tomato
alpha and beta carotene found abundantly in tomatoes strengthen the immune system in fighting off inflammation from bacteria and viruses in initiated chronic diseases.
Lycopene, a powerful pigment phytochemical inhibited free radicals to facilitate cytotoxicity in the induction of cell damage and apoptosis.
According to the joint study led by Washington State University, lycopene isolated from tomato exerted its host protective effects in the modulation of Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory, and other cytoprotective mechanisms(9),
Similar to garlic, lycopene also activated changes of hepatic phase Ⅰ detoxified enzymes and phase Ⅱ detoxified enzymes against PAH-induced toxicity.
Taken together, intake of the above food daily and regularly may have profound and positive effects in promoting optimal health through cleansing the body of toxins. However, intake of a supplement of the above foods should be taken with exceptional care as acute liver toxicity was reported in some medical literature.
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Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Does the different proteomic profile found in apical and basal leaves of spinach reveal a strategy of this plant toward cadmium pollution response? by Fagioni M1, Zolla L.(PubMed)
(2) Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan by Wang E1, Wink M1(PubMed)
(3) Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury by Yoshida K1, Ushida Y1, Ishijima T1, Suganuma H1, Inakuma T1, Yajima N1, Abe K1, Nakai Y1.(PubMed)
(4) Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells by Mithen R1, Faulkner K, Magrath R, Rose P, Williamson G, Marquez J.(PubMed)
(5) Sodium 2-propenyl thiosulfate derived from garlic induces phase II detoxification enzymes in rat hepatoma H4IIE cells by Chang HS1, Ko M, Ishizuka M, Fujita S, Yabuki A, Hossain MA, Yamato O.(PubMed)
(6) Garlic oil attenuatednitroso diethylamine-inducedd hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes by Zhang CL1, Zeng T, Zhao XL, Xie KQ.(PubMed)
(7) Survey of the detoxification effect of green tea extract on the reproductive system in rats exposed to lead acetate by Sha'bani N1, Miraj S2, Rafieian-Kohpayei M3, Namjoo AR4(PubMed)
(8) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG by Na HK1, Surh YJ.(PubMed)
(9) Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raisehealth-promotingoting factors byPall ML1, Levine S2.(PubMed)
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