Intake of functional food beetroot regularly not only lowers the early occurrence but also provides a natural treatment of bladder cancer without inducing adverse effects.
Bladder cancer is a medical condition characterized by irregular cell growth and multiplied disorderly and uncontrollably in bladder tissues.
According to statistics, men are 4 times like to get bladder cancer compared to women. The condition is the 9th most common cancer worldwide.
Every year, approximately 400, 000 new cases are diagnosed. The 5-year of survival rate including all stages of bladder cancer is about 77% compared to 70% and 65% of 10 years and 15 years respectively.
The survival rate of early diagnosed with bladder cancer is at 98%.
The causes of the bladder are unknown. However, some researchers suggested that smoking and tobacco use is one major cause of bladder cancer.
Long-term exposure to chemicals and irritation of the lining of the bladder due to infection is associated with risk factors for the disease.
The most common symptoms of bladder cancer are blood in urine accompanied by painful urination,... and pelvic pain. You should check with your doctor right away if you experience some of these symptoms.
Dr. Martin C. S. Wong the lead scientist at the joint study conducted by The Chinese University of Hong Kong and other institutes said, "Many European countries experienced incidence rise. A substantial mortality reduction was observed in most countries, yet increases in mortality rates were observed in the Philippines and Iceland. These findings identified countries where more preventive actions are required"(4).
Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the University of Urbino 'Carlo Bo', betaxanthins and betacyanins, isolated from beetroot exerted a significant anti-cancer effect in testing bladder cancer cell lines, through the expression of antioxidant and proapoptotic activities.
The anticancer property of beetroot also displayed a strong anti-angiogenesis by blocking the cancer cell in established new blood vessel signaling.
When used in combination with Vitexin-2-O-xyloside, an apigenin flavone glucoside, betaxanthins, and betacyanins also exerted a strong antiproliferative activity in bladder cancer cell lines, intrinsically and extrinsically in the expression of apoptosis.
The study also indicated that this combination when used conjunction in with conventional chemotherapy not only enhance the effectiveness of treatment in bladder cancer but also overcome the adverse effect of toxicity and multidrug resistance of cancer cells.
Furthermore, in another study conducted by the same university, Betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) tested, alone or in combination with vitexin-2-O-xyloside (XVX) also isolated from the same vegetable enhanced the ability to reduce the proliferation rate in T24 bladder cancer cells, synergistically,. by inhibition of protein of gene in promoted cell survival and enhanced cancer apoptosis.
Taken together, a diet enriched with these bioactive molecules of beetroot could be used as a functional food in the prevention and treatment of human bladder cancer.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
(2) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Scarpa ES1, Emanuelli M2, Frati A1, Pozzi V2, Antonini E1, Diamantini G1, Di Ruscio G3, Sartini D3, Armeni T3, Palma F1, Ninfali P1.(PubMed)
(3) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES1.(PubMed)
(4) The global epidemiology of bladder cancer: a joinpoint regression analysis of its incidence and mortality trends and projectio by Martin C. S. Wong,
1,2 Franklin D. H. Fung,1 Colette Leung,1 Wilson W. L. Cheung,1William B. Goggins,3 and C. F. Ng(PMC)
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