Saturday, 1 July 2023

#GreenTea's Polyphenols Reduce the Risk of Death in Patients with Pneumonia, throught Antiinflammatory Activities, Researchers Suggest

Kyle J. Norton

Green tea may have a therapeutic and positive effect in inhibiting the onset of pneumonia, some scientists suggested.
Pneumonia is a lung infection caused by bacteria, viruses, or fungi. The disease may be contagious, as it can spread from person to person, depending on the types of infectious pathogens.

However, pneumonia induced by fungi passed from the environment to humans is not contagious from person to person.

Bacteria Gram-positive cocci. Streptococcus pneumonia is the most cause of community-acquired pneumonia in adults and Haemophilus influenza is the second most common cause of bacterial pneumonia.

Additionally, people who have a weakened immune system, are hospitalized or on a ventilator. and smoking is most likely to be infected with the disease.


Certain chronic medical conditions including asthma, chronic obstructive pulmonary disease, structural lung disease, and heart disease are found to associate with an increased risk of pneumonia.

The common symptoms include chest pain when you breathe or cough, persistent coughing, and fatigue. fever, sweating, and shaking chills. If you are over the age of 50, you may also have the symptoms of confusion or changes in mental awareness

According to the statistic, the disease affects over approximately 450 million people a year, in all parts of the world.

Green tea is a precious drink processed number of health benefit known to almost everyone in Asia and the Western world.

In the investigation of green tea bioactive polyphenol catechins activity in the inhibition of infectious agents, researchers at the Tohoku University Graduate School of Medicine launched a population-based cohort study, with follow-up from 1995 to 2006, using the database of National Health Insurance beneficiaries in Japan (19,079 men and 21,493 women aged 40-79 y).

Participants with missing reports of green tea consumption and a history of cancer, myocardial infarction, stroke, and extreme daily energy intake at baseline were excluded.

The comparison of green tea intake and the risk of death in patients with inflammatory pneumonia was analyzed according to the Cox proportional hazards regression analysis.

According to the review, after 12 years of follow-up, researchers found that participants who drink <1, 1-2 cups/d, 3-4 and > or =5 cups/d expressed a reduced risk of the hazard of 1, 0.59, 0.55, 0.53, respectively.

These results indicated that green tea intake was associated with a significantly lower risk of death in patients with pneumonia.

Also, the results of the efficacy of green tea increased substantially and linearly to the number of cups consumed per day.

Further analysis to confirm the inhibitory effects of tea polyphenols on Chlamydia trachomatis and C. pneumonia. In vitro, researchers at the Saitama Medical School, Iruma conducted an experiment of injection of tea polyphenols, Polyphenon 70S into Chlamydial strains including C. trachomatis D/UW-3/Cx and L(2)/434/Bu, and C. pneumonia AR-39 and AC-43 strains cultivated in cells and HL cells.

At the final phase of the experiment, researchers indicated that in the pre-inoculation method, the application of Polyphenon 70S Completely inhibits both straits without inducing any adverse effects.

However, in the post-inoculation method, injection of Polyphenon 70S at a dose of 0.5 mg/ml demonstrated no inclusive effect against C. trachomatis but induced toxicity to HeLa229 cells and HL cells at a concentration of 0.25 mg/ml.

Additional differentiation concluded that the application of tea polyphenols may be considered as a potential topical usage.

Interestingly, in the study to clarify the in vitro effect of EGCG on C. pneumonia mediated IgE responses by peripheral blood mononuclear cells (PBMC) in asthma by using PBMC from subjects with asthma and non-asthmatic controls incubated with C. pneumonia and cultured for 10 days ±EGCG (0.5, 5.0, 50 ng/mL), with IgE levels of PBMC from non-asthmatics of <2.0 ng/mL) at baseline, scientists showed that application of EGCG (0.5-50 ng/mL) displays a significant inhibitory effect of PBMC from the asthma patient, by suppressing the IgE production in a dose-dependent manner (10-30%), compared to no EGCG treatment group.

More importantly, the injection of green tea EGCG exerted an insignificant effect against PBMC from non-asthmatics incubated with C. pneumoniae as the IgE levels are undetectable (<2.0 ng/mL).

These results suggest that green tea EGCG demonstrated a cell protective activity against bacterial invasion through its cytotoxicity without causing harm to nearby healthy cells.

Taken together, green tea and its bioactive polyphenols may be considered a functional food in amelioration of the risk and treatment of pneumonia. Intake of green tea as a supplement should be taken with extreme care, as acute liver toxicity was reported in a number of cases.

However, further data collection on large example size and multi-center studies performed with human consumption of the beverage during the course of the disease will be necessary to complete the picture of green tea anti-pneumonia possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Green tea and death from pneumonia in Japan: the Ohsaki cohort study by Watanabe I1, Kuriyama S, Kakizaki M, Sone T, Ohmori-Matsuda K, Nakaya N, Hozawa A, Tsuji I.(PubMed)
(2) In vitro inhibitory effects of tea polyphenols on the proliferation of Chlamydia trachomatis and Chlamydia pneumonia by Yamazaki T1, Inoue M, Sasaki N, Hagiwara T, Kishimoto T, Shiga S, Ogawa M, Hara Y, Matsumoto T.(PubMed)
(3) Epigallocatechin gallate suppresses Chlamydia pneumoniae mediated IgE responses in peripheral blood mononuclear cells: a pilot study by Smith-Norowitz TA1, Chotikanatis K, Tam E, Norowitz YM, Joks R, Durkin HG, Hammerschlag MR, Kohlhoff S.(PubMed)
(4) Protective effects of (-)-epigallocatechin-3-gallate against TNF-α-induced lung inflammation via ROS-dependent ICAM-1 inhibition by Lee IT1, Lin CC, Lee CY, Hsieh PW, Yang CM. (PubMed)

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