Kyle J. Norton
Green tea may have a therapeutic and positive effect in reduced risk, progression, and treatment of amyotrophic lateral sclerosis (ALS), some scientists suggested.
Green tea is a precious drink that processed a number of health benefits and is known to almost everyone in Asia and the Western world.
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a specific disease that involved the death of neurons in controlling voluntary muscles.
According to the research published by Hanyang University, the administration of green tea Epigallocatechin gallate (EGCG) exerted a neuroprotective effect in reduced oxidative stress in orchestrated death of neurons.
In the evaluation of green tea EGCG in risk of amyotrophic lateral sclerosis (ALS) in human G93A(with function is responsible for destroying free superoxide radicals in the body) mutated Cu/Zn-superoxide dismutase (SOD1) gene in mice model, scientists found that
application of green tea EGCG at doses of 1.5, 2.9, and 5.8 microg/g body weight, dissolved in 0.5 ml of 0.9% sterile NaCl intraorally every day after 60 days of age demonstrate significant effects in prolonged symptom onset and life span of ALS mice through preserved more survival and attenuated death signals.
The result of the increased life span of mutated gene mice was attributed to the increased antioxidant activity of green tea in inhibiting the levels of ROS in reduced cytotoxicity in initiated death of neurons in controlling voluntary muscles.
Further analysis of the effect of green tea in mutated SOD1-G93A in transgenic mice and wild-type mice randomly divided into EGCG-treated groups (10 mg/kg, p.o) and vehicle-treated control groups to assess the motor function, starting at the age of 70 days researchers found that injection of green tea treatment mice displays a strong effect in delayed the onset of disease, and extended life span, similar to those in the Hanyang study.
Additional differentiation also indicated that the green tea treatment group stimulated the production of a number of new motor neurons compared to control mice,
Interestingly, the application also decreased the over-expression of microglial activation in initiating the inflammatory response due to neuronal damage and removed the damaged cells caused by phagocytosis production.
Prolonged and over-expression of inflammatory cytokines may increase the risk of neuron damage and in some cases death of the nerve cells.
In in-depth analysis showed that green tea reduced the immunohistochemical reaction of NF-kappaB in response to the neuron damage (by antigens) through stimulated production of pro-inflammatory factors (as an antibody) and cleaved caspase-3 in the induction of neuron apoptosis.
Moreover, the application of green EGCG also expressed a similar result as in other studies in the decreased protein level of iNOS and NF-kappaB in the spinal cords in orchestrated free radical NO levels and inflammatory cytokines in neuron cell death in the spinal cord involving the onset of ALS.
Dr. Xu Z, the lead author after taking into account other co-founders said, "This study provides further evidence that EGCG has multifunctional therapeutic effects in the mouse model of ALS".
These results were supported by the study of the green tea effect on the risk of Lou Gehrig's disease by reviewing the food selection of a 44-item food frequency questionnaire of 1 million men and women enrolled and conducted in 1989 through 2002 for ALS mortality.
According to the results of the study, researchers at the Harvard School of Public Health suggested that green tea injection is associated with a reduced mortality rate of patients.
The information findings suggested that green tea and its bioactive polyphenol Epigallocatechin gallate (EGCG) may be considered as a functional food for reduced risk and used in combination with standard medicine in delayed progression and treatment of Amyotrophic lateral sclerosis (ALS).
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Diet and amyotrophic lateral sclerosis by Morozova N1, Weisskopf MG, McCullough ML, Munger KL, Calle EE, Thun MJ, Ascherio A.(PubMed)
(2) Neuroprotective effects of (-)-epigallocatechin-3-gallate in a transgenic mouse model of amyotrophic lateral sclerosis by Xu Z1, Chen S, Li X, Luo G, Li L, Le W.(PubMed)
(3) The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice by Koh SH1, Lee SM, Kim HY, Lee KY, Lee YJ, Kim HT, Kim J, Kim MH, Hwang MS, Song C, Yang KW, Lee KW, Kim SH, Kim OH. (PubMed)
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