Saturday 8 July 2023

#Greentea and Its #EGCG inhibit Genes and Patways Associated with Tissue Inflammation of #Osteoarthritis, Researchers Reveal

Kyle J. Norton

Regular drinking of green tea may have a positive effect in reducing symptoms of pain and treatment of osteoarthritis, a study by a respectable institute postulated.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But a slice of ginger will neutralize that adverse effects.

Osteoarthritis (OA), a form of arthritis, is a condition characterized by aging progression of wear and tear on a joint, affecting over 25 million people in the United States alone

In a randomized open-label active-controlled clinical trial of 50 adults with osteoarthritis of the knee allocated to receive the green tea extract (in dosage form of tablet) plus diclofenac tablet as "intervention group"; or: diclofenac tablet alone as "control group" for a period of four weeks, combination-treated group exerted a significant improvement of physical function in compared to control.

The treatment group also expressed similar progress in pain reduction during knee joint physical function in adults with osteoarthritis as in the control group.


Additionally, in the compared the effect of curcuminoids extract, hydrolyzed collagen, and green tea extract, in chondrocytes culture cells, researchers found that a combination of all components scores an enormous expression of reduced production of pro-inflammatory cytokins through various mechanisms, including ameliorated free radical elucidation.

Furthermore, in support of the above differentiation, the study in the investigation of a posttraumatic osteoarthritis (OA) mouse model tested with EGCG against the progression of OA and relieve OA-associated pain, suggested that EGCG-treated mice promoted cartilage production against Safranin O, staining of the knee joint cartilage loss and cartilage erosion in compared to the control group with no treatment.
Importantly, the cartilage of treated mice also displays a significant reduction of genes in regulated degeneration of connective tissue as well as pathways involved in the promotion of tissue inflammation.

Moreover, the pain score of treated mice also exhibited a significant enhancement compared control group.


Taking together, there is no doubt that the green tea process is a therapeutic and integrated form for the prevention and treatment of symptoms of pain as well as improved physical activity of OA patients through protection against cartilage degeneration.


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Author: Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1)Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial by Hashempur MH1, Sadrneshin S2, Mosavat SH3, Ashraf A4. (PubMed)
(2) Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer by Comblain F1, Sanchez C1, Lesponne I2, Balligand M3, Serisier S2, Henrotin Y4.(PubMed)
(3) Green tea polyphenol treatment is chondroprotective, anti-inflammatory, and palliative in a mouse post-traumatic osteoarthritis model by Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB. (PubMed)

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