Kyle J. Norton
The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells.
In the US, lung cancer is the leading cause of cancer deaths, including 88,329 men and 70,354 women, according to the 2007 statistics.
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
Researchers do not the exact causes of lung cancer.
Genetic mutation inherited from the parents is a result of an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to increase a person's chance of developing lung cancer.
However, not all people who carry mutated lung cancer genes will develop lung cancer.
Cigarette smoking risk of lung cancer, researchers believe cigarettes contain high amounts of cancer-causing substances (carcinogens), when inhaled, the cigarette smoke carried the chemical toxins to the lung cell directly, and prolonged periods exposed to such chemicals can alternate lung cell DNA, leading to the early onset of lung cancer.
Some researchers suggested genetic mutation and long-term cigarette smoking are 2 major risk factors associated with the alternative of lung cell DNA.
Truly, according to the statistic, approximately 8% of lung cancers are inherited or occur as a result of a genetic predisposition.
On finding a potential phytochemical for the treatment of lung diseases, researchers examined the growth inhibitory effect of a gamma-tocopherol-enriched tocopherol mixture (gammaTmT) against CL13 murine lung cancer cells grown in culture and as subcutaneous tumors in A/J mice.
According to the analysis,
* GammaTmT had no effect after 2 days and weakly inhibited the growth of CL13 in culture after 5 days (28% growth inhibition at 80 microM).
* Furthermore, dietary treatment at doses of 0.1 and 0.3% gammaTmT for 50 days inhibited the growth of CL13 tumors in A/J mice by 53.9 and 80.5%, respectively.
* According to the histopathological analysis, gammaTmT revealed an increase in tumor necrosis compared to control tumors.
* Moreover, dietary treatment with gammaTmT dose-dependently increased gamma- (10.0-37.6-fold) and delta-tocopherol (8.9-26.7-fold) in the tumors of treated mice compared to controls.
* Additionally, dietary treatment with gammaTmT also increased plasma gamma- (5.4-6.7-fold) and delta-tocopherol (5.5-7-fold). Whereas others have demonstrated the cancer-preventive activity of gammaTmT against mammary and colon cancer, this is the first report of growth-inhibitory activity against lung cancer.
Taken together, tocopherols may be considered a supplement for reducing the risk of lung cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tocopherols and tocotrienols as an anticancer treatment for lung cancer: future nutrition by Zarogoulidis P1, Cheva A, Zarampouka K, Huang H, Li C, Huang Y, Katsikogiannis N, Zarogoulidis K. (PubMed)
(2) Inhibition of lung cancer growth in mice by dietary mixed tocopherols by Lambert JD1, Lu G, Lee MJ, Hu J, Ju J, Yang CS. (PubMed)
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