By Kyle J. Norton
Cascara sagrada may have a potential effect in inhibiting the onset and progression of prostate cancer, some scientists suggested.
Prostate cancer is medical a condition in which the cells of the prostate have become cancerous, causing abnormal cell growth which spread to distant parts of the body.
Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams. However, some prostate cancers can grow and become invasive quickly.
According to the study of The University of Texas MD Anderson Cancer Center, metastasis to the bone caused by tumor/microenvironment interactions remains the major cause of death in advanced prostate cancer(3).
In other words, this invasion may be a result of certain cancer cells that can reseed the primary site and gain more metastatic potential in the process.
The exact causes of prostate cancer are unknown, however, certain conditions may associate to increase the risk of prostate cancer, including age, ethnic group, family history,... and obesity.
Some researcher suggested that diet high in calcium is linked to an increased risk of developing prostate cancer and maternal high fat diet (HFD) is associated with increased risk children prostate cancer(4).
Most patients may not experience any symptoms until an advanced stage.
The most common symptoms include frequent urination, loss of bladder control such as weak or interrupted urine flow or the need to strain to empty the bladder, and the urge to urinate frequently at night. In severe cases, patients may also find blood in the urine and lost of erection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belongings to the family Rhamnaceae, native to western North America,
The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
Aloe-emodin, a chemical constituent found in Cascara Sagrada is found to inhibit both proliferation and anchorage-independent growth of PC3 cells by targeting the protein complex that plays an important role in stimulated cancer cell metabolism (mTORC2) for survival and expansion.
Further analysis also found that the application of aloe-emodin also suppressed the function of Protein kinase B, (Akt) of a cancer cell in signaling protection of cell survival, increased cell cycle progression and cellular growth, and protein kinase C alpha (PKCα) in the promotion of cancer cell migration.
Dr. Liu K, the lead author at The World Class Institute and Chemical Biology Research Center at the end of the experiment wrote, " Aloe-emodin (also) exhibited tumor suppression effects in vivo in an athymic nude mouse model" and "Collectively, our data suggest that mTORC2 plays an important role in prostate cancer development and aloe-emodin suppresses prostate cancer progression by targeting mTORC"
Epidemiologically, emodin (ED), another bioactive compound found in cascara sagrada, also processed anti-proliferation and induced apoptosis, suppressed angiogenesis, impeded metastasis, and enhanced chemotherapy.
In DU145 and A549 cells, the application of emodin suppressed the expression of both mutation gene CXCR4 and HER2 which are associated to prorate cancer risk without affecting cell viability in tumor cells and protects healthy cell integrity against mutated gene CXCL12 in the induction of cancer cells migration and invasion.
Additional differentiation suggested the efficacy of emodin in inhibiting mutated gene expression of prostate cancer was attributed to the bioactive activity in the prevention of a cancer cell in promoted mRNA expression and suppressed of NF-κB in the activation of cancer cell proliferation.
These results indicated that emodin may have the potential used as a novel blocker of CXCR4 expression as well as a powerful therapeutic agent for metastatic cancer.
The findings showed that herbal Cascara Sagrada (Rhamnus purshiana) with bioactive components that have strong effects in inhibited prostate cancer cells may be considered a functional food for the treatment of prostate cancer.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.
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