Friday, 7 July 2023

#Capsaicinoids Found in #CayennePepper Contribute to Weight Management through Reductions in Energy Intake, Researchers Say

Kyle J. Norton

The prevalence of obesity is widespread in the Western world. In the US, approximately 68% of the population is either overweight or obese.

The findings of weight loss from the botanic plant with little or no side effects have gone under extensive research.

Cayenne, the kitchen spice may have a profound effect on enhanced weight loss, some researchers suggested.

Obesity is a medical condition of excess body fat accumulated over time, while overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.


Weight loss is an intentional reduction of the total body mass through the context of diet, exercise, and medicine such as FDA-approved prescription medications, orlistat (Xenical, Alli), lorcaserin (Belviq), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), and liraglutide (Saxenda).

Although approved medicine may be effective if the person who takes the drug also follows a reduced-calorie, low-fat diet, however, it may induce side effects of weakness, dark urine, clay-colored stools, itching, loss of appetite, or jaundice (liver toxicity).

In severe cases, intake of the drug may cause severe lower back pain, blood in your urine, drowsiness, confusion, mood changes, increased thirst; swelling,...... and shortness of breath.

If you are taking the weight-to-lose approved pills, please make sure that you discuss the side effect with your doctor in advance.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belongings to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The herb has been used in traditional medicine to increase metabolism, enhance the circulatory system and stomach and intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The Phyto Ingredients
The chemical constituents of Cayenne include capsaicin, capsaicin oil, solanine, xanthenes, oleic acid,..... and palmitic acid.

Capsaicinoids are major bioactive chemical compounds found in cayenne, in the study to review its effectiveness in weight management, the Manchester Metropolitan University conducted a selection of 20 trials that satisfied the criteria, and guidelines were selected involving 563 participants.

Most trials were generally of high quality with a low risk of bias, however, trial duration, dosage, and size varied.

Observation and differentiation of these studies suggested that the application of capsaicinoids induces weight loss and weight management by(1)
* Increased energy expenditure by approximately 50 kcal/day, these results would produce clinically significant levels of weight loss in 1-2 years.

* Reduced abdominal adipose tissue levels and reduced appetite and energy intake, and

* Increased lipid oxidation to induce weight loss. Decrements in fatty acid oxidation were associated with obesity.

Dr. Whiting S, the lead scientist in the final report of the study said, "The mechanism of action is not presently fully understood, although it is well accepted much of the effects are caused by stimulation of the TRPV1 receptor (which plays an essential role to induce weight loss through direct impact on enhancing intracellular Ca2+ levels in initiated fat lipid oxidation)".

Further analysis of capsaicinoids weight loss in search of related studies' medical data found 74 clinical trials identified, with only 10 selected, 8 of which provided results suitable to be combined in analysis (191 participants) and 19 effect sizes extracted and analyzed using MIX meta-analysis software conducted by the study led by the School of Healthcare Science, suggested that capsaicinoid ingestion prior to a meal reduced ad libitum energy intake by 309.9kJ (74.0kcal) during the meal(2).

The study also found that a minimum dose of 2mg of capsaicinoids is needed to contribute to weight management through reductions in energy intake(2).

These results were attributed to capsaicinoids efficacy in altered carbohydrate-rich foods that have a significant impact on reduced fat oxidation in the induction of weight gain(2)

Dr. said, "Daily consumption of capsaicinoids may contribute to weight management through reductions in energy intake. Subsequently, there may be potential for capsaicinoids to be used as long-term, natural weight-loss aids".


Intake of herbal Cayenne or its supplements should only be prescribed by herbalists as acute ingestion of a large number of chili peppers (the rich source of capsaicin) was found to induce produced
hypertension in some patients(3).

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence by Whiting S, Derbyshire E, Tiwari BK. (PubMed)
(2) Could capsaicinoids help to support weight management? A systematic review and meta-analysis of energy intake data(PubMed)
(3) Mechanisms underlying the hypertensive response induced by capsaicin" by Dutta A, Deshpande SB. (PubMed)

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