#Caffeic Acid and #Greentea's #EGCG Express a Significant Reduction on #Alzheimer's disease #AD, According to Studies

Kyle J. Norton

Green tea may be an integrated form of treatment for patients with Alzheimer's disease through many mechanisms, a recent study proposed.
Green tea, considered as a functional food, linking a number of health benefits has been reported by several renowned research and studies. However, as yin in nature herbal medicine, or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "excessive yin syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. But a slice of ginger in the drink will neutralize the yin-over expression in green tea.


Alzheimer's disease is a neuro-degenerative condition of loss or decrease of cognitive and memory functions due to aging.

According to the Maternal and Infant Health, ASL NA 3 SUD, epigallocatechin, and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG), found in green tea exerted strong anti-inflammatory and anti-oxidative properties in protection against neuronal damage and brain edema.

The study also stated that green tea may also contribute to reduced risk and treatment of AD by ameliorating chronic viral infection, one of the causes responsible for AD's neuropathology.


Dr. Mandel SA. the lead author and expert in the green tea study said, "Tea drinking may decrease the incidence of dementia, AD, and PD. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate (EGCG) has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders".

Other researchers suggested that the efficacy of epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) in reduced risk of AD may be attributed to
1. The antioxidant activity in ameliorating the production of ROS in induced risk of oxidative stress has been found to associate with the production of lipid peroxidation, leading to abnormal deposition of amyloid β (Aβ) peptide

2. Free radical overexpression in aging people is also vulnerable to the imbalance of antioxidants and ROS may have negative direct interaction with proteins, nucleic acids, and other molecules and may also alter their structures and functions in inducing risk AD.

Indeed, as a single ingredient isolated from green tea, epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) have been found to cause toxicity in some cases in medical literature. Therefore taking the ingredient in the long term and overdoses may have an implication of liver damage.

In an animal study to evaluate the efficacy of Caffeic acid in AD, mice rats were randomly divided into three groups: i) the control group, ii) the AD model group, and iii) the caffeic acid group, mice fed with the phytochemical expressed a significantly increased learning deficit and cognitive function demonstrated by the Morris water maze task in compared control.

Additionally, fed mice also displayed attenuated oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression involved inflammatory cytokins production and suppressed caspase‑3 activity-induced cell death and other mechanisms in the rats with AD.

Interestingly, the inflammatory process has been shown to have a negative role in an increased risk of AD, by causing neuroinflammation, including brain cells such as microglia and astrocytes, and subsequently in promoting dysfunction and neuronal death. Therefore by suppressing the production of inflammatory cytokins, caffeic acid expressed a significant reduction in AD risk.

The efficacy in the contribution of cognitive improvement following caffeic acid application may be due to its antioxidant activity and restoration of cholinergic functions, as deficiency of cholinergic function has shown to affect cognition, behavior, and activities of daily living

Taking it all together, there is no doubt that the green process is a neuroprotective against the risk and progression of patients with Alzheimer's disease (AD) attributed to some of the major chemical constituents. But intake of a single ingredient isolated from green tea should be taken with care.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma anSciencecience, ISSN 0975-6299.

Sources

(1) The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice by Cascella M#1, Bimonte S#1, Muzio MR2, Schiavone V3, Cu omo A1. (PubMed)
(2) Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective stratAlzheimer'slzheiParkinson'sarkinson diseases by Mandel SA1, Amit T, Weinreb O, Reznichenko L, You dim MB. (PubMed)
(3) Effects of caffeic acid on learning deficits in a model of Alzheimer's disease by Wang Y1, Wang Y2, Li J1, Hua L3, Han B1, Zhang Y1, Yang X3, Zeng Z3, Bai H3, Yin H1, Lou J3.(PubMed)
(4) Caffeic acid attenuates oxidative stress, learning, and memory deficit in intra-cereventricstre ptozotocin-induced experimental dementia in rats by Deshmukh R1, Kaundal M2, Bansal V2, Samardeep2(PubMed).