A glioma is a type of tumor that starts in the glial cells of the brain or the spine, comprising 30 percent of all brain tumors and central nervous system tumors.
Heterogeneous tumor cells of glioma are the type of cancer associated with genetic alterations that occur in individual tumors originating in the same organ.
According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.
Where PDCP-NP is a cationic micellar core (Cur-M) that was first prepared from d-α-tocopherol-grafted-ε-polylysine polymer to encapsulate the hydrophobic curcumin, followed by dopamine-modified-poly-γ-glutamic acid polymer further deposited on its surface as an anion shell through pH-sensitive linkage to encapsulate the hydrophilic doxorubicin (DOX) hydrochloride with the control of the combinational Cur/DOX molar ratio at 3:1.
According to the analysis, PDCP-NP showed a ratiometric delivery capability to target cancer stem cells (CSCs) and the differentiated tumor cells in vitro and Vivo, compared to those of the cocktail Cur/DOX solution.
Treatment with PDCP-NP displayed a significantly decreased percentage of CSCs in tumors from 4.16% to 0.95%.
Based on the results, researchers said, " PDCP-NP may be a promising carrier for the combination therapy with drug candidates having dissimilar physicochemical properties".
Primary glioblastoma is considered the most aggressive cancer. Cancer may arise de novo, meaning they begin as a Grade IV malignant glioma tumor with no evidence.
Due to the rapid growth of the tumor, patients diagnosed with primary glioblastoma experience brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, and severe headaches and localized symptoms depending on the location of the tumor.
Radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.
Radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.
According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.
Believe it or not, gliomas have been found accounting for 30 percent of all brain tumors and central nervous system tumors, and 80 percent of all malignant brain tumors.
Glioma can be classified into 3 types, including
* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.
* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.
* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.
The exact cause is unknown. Epidemiologically, age, exposure to radiation and family history are common risk factors that cause the onset of the disease,
Glioma can be classified into 3 types, including
* Astrocytomas are found in glial cells, star-shaped brain cells in the cerebrum called astrocytes. Most astrocytomas are localized.
* Ependymomas are cancers that grow in your brain or any part of the spine, including your neck and upper and lower back starting from the ependymal cells in the middle of your spinal cord and fluid-filled spaces in your brain.
* Oligodendrogliomas are cancers that begin on the oligodendrocytes of the brain or from a glial precursor cell.
The exact cause is unknown. Epidemiologically, age, exposure to radiation and family history are common risk factors that cause the onset of the disease,
Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.
On finding a most effective approach to glioma treatment, researchers examined the effects of a pH-sensitive core-shell nanoparticle (PDCP-NP) that targets the cancer stem cells (CSCs) and the differentiated tumor cells.
On finding a most effective approach to glioma treatment, researchers examined the effects of a pH-sensitive core-shell nanoparticle (PDCP-NP) that targets the cancer stem cells (CSCs) and the differentiated tumor cells.
Taken altogether, tocopherols used in a combination with other phytochemicals and chemo drugs may be considered an adjunct therapy for the treatment of glioma, pending to the confirmation of the larger sample size and multicenter human study.
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ratiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core-shell nanoparticles targeting the heterogeneous tumor cells of glioma by Xu HL1, Fan ZL1, ZhuGe DL1, Tong MQ1, Shen BX1, Lin MT1, Zhu QY1, Jin BH1, Sohawon Y2,3, Yao Q1, Zhao YZ. (PubMed)
Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ratiometric delivery of two therapeutic candidates with inherently dissimilar physicochemical property through pH-sensitive core-shell nanoparticles targeting the heterogeneous tumor cells of glioma by Xu HL1, Fan ZL1, ZhuGe DL1, Tong MQ1, Shen BX1, Lin MT1, Zhu QY1, Jin BH1, Sohawon Y2,3, Yao Q1, Zhao YZ. (PubMed)
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