Friday, 21 January 2022

Omega-3 Fatty Acid Inhibits the Depressive Symptoms Regardless of Serum of Oxidated-LDL/LDL

By Kyle J. Norton

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness.

Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate. Depression may be a mental health disorder that can affect the way you eat, sleep, and the way you feel about yourself. 

The mild case of depression can be defeated by a variety of self-care techniques. Others require the treatment of medication, such as antidepressant medications and psychotherapy that help to reduce and sometimes eliminate the symptoms of depression.

The most common depressive symptoms are feelings of helplessness and hopelessness, loss of interest in daily activities, appetite or weight changes, sleep changes, anger or irritability, reckless behavior and loss of concentration.

Cholesterol is a waxy substance that is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

In other words, healthy blood cholesterol is any level with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).

According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.

Lipoproteins are a general term of fat, cholesterol, and apolipoproteins, including the 2 most common forms of LDL (Low-Density Lipoprotein) and HDL (High-Density Lipoprotein).

Low-Density Lipoprotein is also known as bad cholesterol in the form of lipoprotein in which cholesterol is transported in the blood. High levels of low-density lipoprotein in the blood are associated with an increased risk of heart disease.

Lipoprotein ratio is the calculation of total/high-density lipoprotein (HDL) cholesterol and LDL/HDL cholesterol ratios which are considered indicators with greater predictive value than isolated parameters used independently in the prediction of the risk of heart disease.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of high blood cholesterol, researchers examined the effect of Omega 3 fatty acid on low-density lipoprotein on patients LDL with depression

The study included a total of 133 female workers in a hospital and nursing homes recruited in Japan.
According to the tested analysis, serum oxidated-LDL/LDL was positively connected with depressive symptoms but was more strongly related to perceived psychological stress.

Patients showed an increased serum of pro-inflammatory cytokine (IL-6)  partly transmitted via ox-LDL/LDL with a positive correlation with depressive symptoms.

Serum ω3 PUFAsfound in the blood were inversely associated with depressive symptoms independently of IL-6 or ox-LDL/LDL.

Taken altogether, Omega-3 fatty acids may be considered a functional food for the treatment of depressive symptoms regardless of the levels of the IL-6 or ox-LDL/LD, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Serum IL-6 levels and oxidation rate of LDL cholesterol was related to depressive symptoms independent of omega-3 fatty acids among female hospital and nursing home workers in Japan by Tsuboi H1, Sakakibara H2, Tatsumi A3, Yamakawa-Kobayashi K4, Matsunaga M5, Kaneko H6, Shimoi K7. (PubMed)

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