Saturday, 27 February 2021

Red Cabbage May Process a Significant Antioxidant and Cytotoxic Activity

By Kyle J. Norton

Cytotoxicity is the process in the induction of cell death through toxins.

In other words, cell cytotoxicity is the process to use certain chemicals to destroy living cells.

In general, cytotoxicity can cause the death of healthy cells

In cancers, cytotoxicity can be benefits to humans by destroying the cancer cells and prevent them from proliferation.

For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.

More precisely, most cases of cancer cell cytotoxicity are associated with the stimulation of protein and pathways involved in either gene suppression or cell death programming.

The aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.

Before the preparation can be used in humans, bioassays associated with a number of different cell lines in vitro and Vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants.

However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells. 

Many herbal medicines and foods such as fennel (*) , Onion (*), and tomato(*) have been found not only to promote the chemo drug cytotoxic activity against target tumors, but also protect the healthy cells against the chemo drugs side effects.


With an aim to find a natural food for the treatment of cancers, researchers the roles of zeatin (2 mg/L) on antioxidants and cytotoxic activity in regenerated shoots of red cabbage.  

Red cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded with a mass of leaves.

Based on the results of differentiation,
* The extract of a plant treated by 2 mg/L zeatin gives the highest content of total phenolics (5.18 mg gallic acid equivalent/g dry weight) and flavonoids (1.52 mg rutin equivalent/g dry weight).

* Furthermore, various bioactive compounds in red cabbage are significantly enhanced with increasing zeatin concentration.

* In vitro shooting culture using 2 mg/L zeatin displayed higher antioxidant activity in all assays (DPPH, FRAP, and ABTS) compared to control with respective values of 68.12%, 73.28%, and 54.1%, respectively.

* Moreover, the extracts of red cabbage explant treated by 2 mg/L zeatin exhibited the strongest cytotoxic effect towards cancer cells compared to control.

Taken altogether, red cabbage combined with Zeatin may be considered a functional food that processes antioxidant and cytotoxic capacity, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Enhancement of phenolic and flavonoids compounds, antioxidant and cytotoxic effects in regenerated red cabbage by application of Zeatin by Ravanfar SA1, Karimi E2, Mehrabanjoubani P3, Ebrahimi M. (PubMed)

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