By Kyle J. Norton
Cancer is a class of diseases associated with irregular cell growth in the tissue of organs.
The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.
Lung cancer is a condition of the abnormal growth of the cells in the lung's tissues. The most common form of primary lung cancers is derived from epithelial cells.
Most cases of lung cancer caused by the alternation of calls DNA begin in the cells on the surface of the inner lining of the lung.
At the advanced stage, the cancer cell from the lung can travel a distance away to infect other healthy tissue and organs through the circulation of fluid and blood, leading to the secondary metastasis.
According to statistics, in 2017, 28,600 Canadians were diagnosed with lung cancer, representing 14% of all new cancer cases. Also in 2017, lung cancer caused the death of 21,100 Canadians.
Although smoking is a major cause of lung cancer, however, not all lung cancer patients with lung cancer are smokers. Nonsmokers' lung cancer may be caused by exposure to radon, secondhand smoke, air pollution, or other factors.
The most common types of lung cancers include
* Squamous-cell carcinoma often found in an outer area of the lung,
* Large-cell carcinoma found in the center of the lung by an air tube
* Adenocarcinoma found in any part of the lung.
Non-small cell lung cancer is the most common type of lung cancer. It usually grows and spreads methodically and predictably.
On finding a potential compound for the treatment of malignant tumors, scientists examined the anti-non-small cell lung cancer effect of polysaccharide, TFPB1, isolated from the flower buds of Tussilago farfara.
Where TFPB1 is a homogeneous polysaccharide with a molecular weight of 37.8kDa and composed of antioxidants, rhamnose, galacturonic acid, glucose, galactose, and arabinose, in a ratio of 13:13:1:7:12.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
According to the differentiation, TFPB1 showed to inhibit cell proliferation of A549 cells and induce cell apoptosis in vitro.
Furthermore, TFPB1 downregulated the protein expression associated with cellular proliferation and cell migration.
Additionally, the administration of TFPB1also enhanced the functions of caspase protein and Fas, FasL, and Bax expression involved in cellular apoptosis by inhibiting the expression of the proapoptotic protein.
Based on the findings, researchers wrote in the final report, " TFPB1 exhibited anti-proliferative and anti-apoptotic effect partly depending on the suppression of the Akt signaling pathway. These findings provided us a potential chemotherapeutic strategy for the treatment of human non-small cell lung cancer".
Taken altogether, coltsfoot may be considered a remedy for the prevention and treatment of Non-small lung cancer, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Structural characterization of a polysaccharide from the flower buds of Tussilago farfara, and its effect on proliferation and apoptosis of A549 human non-small lung cancer cell line by Qu H1, Yang W2, Li J. (PubMed)
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