Saturday, 25 February 2017

The holistic Prevention, Management and Treatment of Dementia due to aging depletion of Kidney Essence - TCM Herbal Du Zhong(Eucommia Bark)

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

   TCM Treatment of Dementia due to aging depletion of Kidney Essence - Herbal Du Zhong(Eucommia Bark)

Based on Chinese ancient medical records, causes of dementia are the results of (*)

3. Du Zhong(Eucommia bark)
Du Zhong, the sweet, slightly acrid, and warm, is also known as eucommia bark, used in traditional Chinese medicine as anti stress(1325)(1326), anti diuretic(1336), anti inflammatory(1327)(1328), anti infectious(1329), sedative and anesthesia and anti-aging(1336) agents and to treat hypertension(1330)(1331), chronic pain in lower back and knees(1332)(1336), lack of strength, dizziness, impotence(1337), irregular menses and frequent urination(1336) and protect against unstable pregnancy(1336),.... by enhancing the functions of liver and kidney channels(1333).

1. Eucommiol
2. Eucommioside
3. Eucommioside-I
4. Cpmoferom
5. Dehydrodiconife4ryl alcohol-4
6. Gamma'-di-O0betta-D-glucopyranoside
7. Liriodendrin
8. (+) -syringaresinol-di-O-Beta-D-glucopyranoside
9. (+)-syringa resinol O-Beta-D-glucopyranoside
10. (+)-syringaresinol monoglucoside
11. syringin
12. Etc.

1. In learning and memory
In scopolamine-induced learning and memory impairments by a single intracerebroventricular (i.c.v.) injection of Aβ(25-35) mice models, oral administration of aqueous extract of Eucommia bark or the whole herb significantly reversed learning and memory deficits, through inhibition of acetylcholinesterase (AChE)(1335) and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus and frontal cortex in a dose-dependent manner(1334)(1335).

2. In Alzheimer's disease (AD)
In hydrogen peroxide (H(2)O(2))-induced neuronal cell death in human SH-SY5Y neuroblastoma cells, eucommia ulmoides Oliv. Bark. (EUE), increased cell viability and inhibited cytotoxicity and DNA condensation, through attenuated the increase in ROS production and MMP involved increased risk of dementia reduction(1337).

3. In neuroprotective effects
In PC-12 cells injury mediated by Aβ(25-35) eucommia ulmoides Oliv. (EUO)bark and leaf's phytochemicals, geniposidic acid and chlorogenic acid, significantly protected PC-12 cells against the cytotoxicity(1338). In amyloid beta(25-35) (Aβ(25-35))-induced learning and memory impairments mice model, the herb laso exhibited neuroprotective effects through inhibition of acetylcholinesterase (AChE) activity in the hippocampus and frontal cortex(1235).

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(1325) Eucommia ulmoides Oliv. bark. attenuates 6-hydroxydopamine-induced neuronal cell death through inhibition of oxidative stress in SH-SY5Y cells by Kwon SH1, Ma SX1, Hong SI1, Kim SY2, Lee SY1, Jang CG3.(PubMed)
(1326) Constituents and pharmacological effects of Eucommia and Siberian ginseng by Deyama T1, Nishibe S, Nakazawa Y.(PubMed)
(1327) Elucidation of anti-inflammatory potencies of Eucommia ulmoides bark and Plantago asiatica seeds by Kim BH1, Park KS, Chang IM.(PubMed)
(1328) Eucommia ulmoides Oliv. bark aqueous extract inhibits osteoarthritis in a rat model of osteoarthritis by Xie GP1, Jiang N2, Wang SN3, Qi RZ4, Wang L5, Zhao PR6, Liang L7, Yu B8.(PubMed)
(1329) Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine by He X1, Wang J2, Li M3, Hao D1, Yang Y4, Zhang C1, He R1, Tao R5.(PubMed)
(1330) A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension by Greenway F1, Liu Z, Yu Y, Gupta A.(PubMed)
(1331) Antihypertensive effect of Eucommia ulmoides Oliv. extracts in spontaneously hypertensive rats by Luo LF1, Wu WH, Zhou YJ, Yan J, Yang GP, Ouyang DS.(PubMed)
(1332) Eucommia bark pain (PubMed)
(1333) Du Zhong(Complementary and Alternative Healing University)
(1334) Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice. by Kwon SH1, Ma SX1, Joo HJ1, Lee SY1, Jang CG1.(PubMed)
(1335) Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice by Kwon SH1, Lee HK, Kim JA, Hong SI, Kim SY, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG.(PubMed)
(1336) Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells by Kwon SH1, Kim MJ, Ma SX, You IJ, Hwang JY, Oh JH, Kim SY, Kim HC, Lee SY, Jang CG.(PubMed)
(1337) Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine by He X1, Wang J2, Li M3, Hao D1, Yang Y4, Zhang C1, He R1, Tao R5.(PubMed)
(1338) Protective effects of Eucommia ulmoides Oliv. bark and leaf on amyloid β-induced cytotoxicity by Zhou Y1, Liang M, Li W, Li K, Li P, Hu Y, Yang Z.(PubMed)

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