Friday, 25 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Salmon Calcitonin

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


                  Polymyalagia Arthritis (Rheumatica)

Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.

B. In herbal  and traditional Chinese medicine perspective
2. Cold water fish Salmon
Salmon is the common name for Salmonidae. They are anadromous, born in fresh water, migrate to the ocean, then travel thousands of miles in the deep sea cold water throughout their life cycle and within to five years returning to the exacted location where they were born to reproduce and die.

1. Protein
2. Omega-3 fatty acids
3. B vitamins
4. Vitamin D
5. Astaxanthin
is a potent antioxidant that stimulates the development of healthy fish nervous systems and enhances the fish's fertility and growth rate.
6. Selenium
7. Tryptophan
8. Magnesium
9. Phosphorus
10. Etc.

Use of salmon calcitonin, a hormone produced by the thyroid gland of salmon or a synthetic polypeptide of the same sequence found in salmon(360, 170) has shown to reduce PMR complications. Dr. Ryan SM and the research team at the Dublin Institute of Technology, suggested that salmon calcitonin may also portent for treatment of inflammatory arthritis through activation of the DNA expression of  of steroid-thyroid hormone-retinoid receptor and  tissue remodeling and degradation of the extracellular matrix (ECM) of  collagens, elastins, gelatin, matrix glycoproteins, and proteoglycan(172).
A randomized controlled trial of salmon calcitonin attenuate bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica patients by reducing the incidence of vertebral fracture of 12.5%, with four fractures in the first year and one fracture in the subsequent year(171).
In Fact, salmon calcitonin has also been used to reduce pain in patient with inflammatory arthritis diseases, including patient with osteoporotic vertebral crush fractures(173) and spinal pain(174).. through its analgesic effect , a prospective double-blind, randomized, placebo-controlled clinical study insisted

(171) A randomized controlled trial of salmon calcitonin to prevent bone loss in corticosteroid-treated temporal arteritis and polymyalgia rheumatica by Healey JH1, Paget SA, Williams-Russo P, Szatrowski TP, Schneider R, Spiera H, Mitnick H, Ales K, Schwartzberg P.(PubMed)
(172) An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis by Ryan SM1, McMorrow J, Umerska A, Patel HB, Kornerup KN, Tajber L, Murphy EP, Perretti M, Corrigan OI, Brayden DJ.(PubMed)
(173) Pain relief from nasal salmon calcitonin in osteoporotic vertebral crush fractures. A double blind, placebo-controlled clinical study by Lyritis GP1, Paspati I, Karachalios T, Ioakimidis D, Skarantavos G, Lyritis PG.(PubMed)
(174) Analgesic effect of salmon calcitonin suppositories in patients with acute pain due to recent osteoporotic vertebral crush fractures: a prospective double-blind, randomized, placebo-controlled clinical study by Lyritis GP1, Ioannidis GV, Karachalios T, Roidis N, Kataxaki E, Papaioannou N,
Kaloudis J, Galanos A.(PubMed)


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