Sunday, 27 March 2016

Most Common Disease of elder: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Polymyalagia Arthritis (Rheumatica): The Preventive Minerals and Vitamins

Kyle J. Norton (Scholar)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


                  Polymyalagia Arthritis (Rheumatica)

Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which causes pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdle as a result of the presence of a synovitis in proximal joints and periarticular structures.


B. In herbal  and traditional Chinese medicine perspective
B.3. The Preventive Minerals and Vitamins
Certain minerals and vitamin such as  magnesium, selenium, copper and vitamin D may be a good sources of pain reliever according to the studies(325,180). According to the randomized to four double-blinded treatments for 12 weeks by Minnesota Applied Research Center, Glucosamine sulfate (1500 mg/d), Aquamin (2400 mg/d) and Combined treatment composed of Glucosamine sulfate (1500 mg/d) have shown effectively in improvements in symptoms of pain and stiffness of osteoarthritis(315,181).
1. Magnesium
Magnesium sulfate has shown to relieve pain in patients undergoing laparoscopic cholecystectomy (LC)(182) and neuropathic pain(183).
According to Dr. Sun J and the research team lead by the Wenzhou Medical University, magnesium used alone or conjunction with ropivacaine are effectively in exhibition of postoperative analgesia in children(184).
In fact, patient with chronic inflammatory diseases are found to associate to magnesium depletion. Dr. Nielsen FH. said," Magnesium deficiency should be considered a nutrient of significant concern for health and well-being"(185).

2. Selenium
Selenium therapy have shown to associate to pain reduction, according to study by Fourth Military Medical University(186).
In chronic pancreatitis, according to the systematic review and meta-analysis was performed per PRISMA guidelines, organic selenium may be effective for treatment of chronic pain as the result of reported change in pain score(187).
According to the Universidad de Buenos Aires, patient with chronic inflammatory diseases are found to have low levels of selenium serum(188).

3. Copper
Used topical Copper-salicylate gel has shown to relief pain for patients with the hip or knee osteoarthritis with side effects of skin rashes(330,189).
Other topical Cu-Indo gel has shown effectively against joint inflammation in the MIA-treated rat model of osteoarthritis(332,190). 
Deficiency of copper is found to associate with inflammation, oxidative Stress, and metabolic variables in adults, according to the 2008 American Society for Nutrition publication(191).

4. Vitamin D
According to the study by the University of Alberta, vitamin D may have beneficial effects in specific chronic painful conditions(192)and Vitamin D deficiency has recently been linked with a range of diseases including chronic pain(193).

All Forms of Arthritis are Curable

Ovarian Cysts And PCOS Elimination

(156) Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans by Bjarnason I1, Hayllar J, MacPherson AJ, Russell AS.(PubMed)
(157) Adverse outcomes of antiinflammatory therapy among patients with polymyalgia rheumatica by Gabriel SE1, Sunku J, Salvarani C, O'Fallon WM, Hunder GG.(PubMed)
(325,180) Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis by Yazar M1, Sarban S, Kocyigit A, Isikan UE.(PubMed)
(325,181) Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis by Yazar M1, Sarban S, Kocyigit A, Isikan UE.(PubMed)
(182) Effect of intraoperative magnesium sulphate infusion on pain relief after laparoscopic cholecystectomy by Mentes O1, Harlak A, Yigit T, Balkan A, Balkan M, Cosar A, Savaser A, Kozak O, Tufan T.(PubMed)
(183) [Relief of neuropathic pain with intravenous magnesium].[Article in Japanese] by Tanaka M1, Shimizu S, Nishimura W, Mine O, Akatsuka M, Inamori K, Mori H.(PubMed)
(184) Pre-emptive peritonsillar infiltration of magnesium sulphate and ropivacaine vs. ropivacaine or magnesium alone for relief of post-adenotonsillectomy pain in children by Sun J1, Wu X2, Zhao X1, Chen F1, Wang W3.(PubMed)
(185) Effects of magnesium depletion on inflammation in chronic disease by Nielsen FH1.(PubMed)
(186) Antioxidant therapy for pain relief in patients with chronic pancreatitis: systematic review and meta-analysis by Cai GH1, Huang J, Zhao Y, Chen J, Wu HH, Dong YL, Smith HS, Li YQ, Wang W, Wu SX.(PubMed)
(187) Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis by Talukdar R1, Murthy HV2, Reddy DN3.(PubMed)
(188) Host selenium deficiency increases the severity of chronic inflammatory myopathy in Trypanosoma cruzi-inoculated mice by Gomez RM1, Solana ME, Levander OA.(PubMed)
(330,189) Copper-salicylate gel for pain relief in osteoarthritis: a randomised controlled trial.Shackel NA1, Day RO, Kellett B, Brooks PM.(PubMed)
(332, 190) Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis by Yassin NZ1, El-Shenawy SM1, Abdel-Rahman RF1, Yakoot M2, Hassan M3, Helmy S4.(PubMed)
(191) Associations of Dietary and Serum Copper with Inflammation, Oxidative Stress, and Metabolic Variables in Adults1,2 by Simona Bo3,*, Marilena Durazzo3, Roberto Gambino3, Carlo Berutti4,
Nadia Milanesio3, Antonio Caropreso4, Luigi Gentile5, Maurizio Cassader3,Paolo Cavallo-Perin3, and  Gianfranco Pagano3(The journal of nutrition)
(192) Vitamin D for the treatment of chronic painful conditions in adults by Straube S1, Derry S, Moore RA, McQuay HJ.(PubMed)
(193) Vitamin D Deficiency Linked to Depression, Pain, Inflammatory Bowel Disease, and Breast Cancer by Dr. Mercola


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