Beta-Sitosterol Protects the Liver Against Liver Toxicity

By Kyle J. Norton

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.

If the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linked to increased mortality, extending to those with chronic liver disease.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.

Hepatotoxicity is a condition caused by the accumulation of toxins in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long-term use of certain medicines.

There are many causes associated with liver toxicity including chemical toxins, which normally induce acute liver toxicity, such as those used in laboratories and industries, natural chemicals, and long-term use of certain medication.

The most common signs and symptoms of liver toxicity include jaundice, abdominal pain, gastrointestinal discomforts, fatigue, Stomach pain. Nausea (upset stomach) Unusual tiredness. dark-colored urine, and pale-colored bowel movements.

Beta-Sitosterol is a phytochemical in the class of phytosterols, belongings to the group of lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the prevention and treatment of liver diseases, researchers examined the pharmacological efficacy of the seed extracts, constituents of the seeds including unsaturated fatty acids linolenic and linoleic acids, and the sterol beta-sitosterol in the 70% EtOH and the MeOH extracts.

According to the chemical analysis, in rat experiment, the seed extracts orally administered attenuated the dimethylnitrosamine-induced hepatopathy, and blood L-aspartate aminotransferase (AST) and L-alanine aminotransferase (ALT) levels, liver retinoid level, and hydroxyproline level.

From the liver perspective, the extracts decreased the levels of AST, ALT, and hydroxyproline levels involved in liver oxidative stress and the rate of liver fibrosis rates.

Hepatopathic rats treated with 70% EtOH and MeOH extracts of the seed showed a higher retinoid level compared to water-treated control rats.

Based on the findings researchers suggested, " the positive effect on liver function of the extracts varies depending on the extracting solvent used. 70% EtOH and MeOH extract of the seeds inhibited the development of liver fibrosis in hepatopathy rats, thus exhibiting potent improvement".

And, " The unsaturated linolenic and linoleic acids and the sterol beta-sitosterol contained in these extracts may also contribute to the improvement of liver function".

Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of liver toxicity pending the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of extract derived from Eriobotrya japonica on liver function improvement in rats by Nishioka Y1, Yoshioka S, Kusunose M, Cui T, Hamada A, Ono M, Miyamura M, Kyotani S. (PubMed)

Broccoli Inhibits the Parameters Associated with Onset of Liver Cancer in Vivo

By Kyle J. Norton

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition caused by fat accumulated in the liver over time, in the absence of excessive alcohol use.

The disease can be classified into the types of non-inflammatory fatty liver (NAFL) and inflammatory nonalcoholic steatohepatitis (NASH).

Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of cirrhosis and liver cancer

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.

Furthermore, the liver produces bile that not only aids the digestive function in food absorption but also builds strong cell membranes, produces vitamin D and steroid hormone.

Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to overexpression of overweight and obese of the population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. In the US, approximately 42,030 new cases including 29,480 in men and 12,550 in women will be diagnosed with liver cancer. The liver cancer also will cause of 31,780 American, including 21,600 men and 10,180 women in 2019.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

On finding a potential wholefood for the treatment of cancer, researchers examined the impact of dietary broccoli on hepatic lipid metabolism and the progression of NAFLD to HCC.

The study included adult 5-wk-old male B6C3F1 mice received a control diet (AIN-93M) or a Western diet (high in lard and sucrose, 19% and 31%, wt:wt, respectively), with or without freeze-dried broccoli (10%, wt:wt). Following week, mice were treated once per week with diethylnitrosamine (DEN; 45 mg/kg body weight intraperitoneally at ages 6, 7, 8, 10, 11, and 12 wk).

Based on the results of the experiment, mice treated by broccoli exhibited lower hepatic triglycerides (P < 0.001) and NAFLD scores (P < 0.0001), decreased liver oxidative stress markers plasma alanine aminotransferase.

Furthermore, dietary broccoli also suppressed the activation of hepatic CD68(+) macrophages and slowed initiation and progression of the hepatic neoplasm associated with the initiation of liver cancer in treated mice.

Furthermore, dietary broccoli decreased hepatic triglycerides observed by suppressing the hepatic Cd36 expression in the contribution to dyslipidemia and increasing the microsomal triglyceride transfer protein involving the secretion of very-low-density lipoproteins.

Collectively, researchers said, "Long-term consumption of whole broccoli countered both NAFLD development enhanced by a Western diet and hepatic tumorigenesis induced by DEN in male B6C3F1 mice".

Taken altogether, broccoli may be considered a functional food for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Broccoli Lessens Development of Fatty Liver and Liver Cancer in Mice Given Diethylnitrosamine and Fed a Western or Control Diet by Chen YJ1, Wallig MA2, Jeffery EH. (PubMed)

Chickpeas Increase the Function of Bowel Health, Researchers Say

Kyle J. Norton

Garbanzo bean is also known as chickpea, an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to the Middle East.

According to the University of Tasmania, diet not only affects food choice, satiety but also has a profound influence on bowel health. 15 participants. who participated in the study tended to eat more processed snack foods (high energy, low fiber) after ceasing chickpea consumption(1).

In 27 free-living adults followed two randomized, crossover dietary interventions each of five weeks duration, Dr. Pittaway JK and research team said,"... significant decrease in serum TC and LDL-C during the chickpea diet compared to the equivalent fiber wheat diet was partly due to unintentional changes in macronutrient intake occurring because of chickpea ingestion"(2).

The effect of chickpea in the promotion of bowel health may be the result of a high amount of dietary fiber found in the peas. The study of the effectiveness of probiotics, prebiotics, and dietary fiber in the treatment of FGD in the pediatric population, suggested that the administration of a fiber supplement is more effective than a placebo for the treatment of childhood constipation(3).

In fact, Fiber undergoes partial or total fermentation after conscription in the distal small bowel and colon leading to the production of short-chain fatty acids and gas, thereby affecting gastrointestinal function and sensation, the University of Michigan Health System, insisted(4).

Taking all together, people who eat a portion of chickpea every day may improve gastrointestinal function, regardless of the type of diet.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Chickpea supplementation in an Australian diet affects food choice, satiety and bowel health by Murty CM1, Pittaway JK, Ball MJ.(PubMed)
(2) Effects of a controlled diet supplemented with chickpeas on serum lipids, glucose tolerance, satiety and bowel function by Pittaway JK1, Ahuja KD, Robertson IK, Ball MJ.(PubMed)
(3) Probiotics, prebiotics, and dietary fiber in the management of functional gastrointestinal disorders by Horvath A1, Szajewska H.(PubMed)
(4) Fiber and functional gastrointestinal disorders by Eswaran S1, Muir J, Chey WD.(PubMed)

Cruciferous Vegetables, the Anti-Hyperlipidemic Functional Foods

By Kyle J. Norton

Hyperlipidemia is a medical condition of abnormally high levels of cholesterol and fat in the bloodstream.

The condition is normally known as high blood cholesterol in the general population.

According to statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older are living with high blood cholesterol with a total cholesterol higher than 240 mg/dL. and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.

In other words, hyperlipidemia has a high prevalent ratio that affects over 100 million Americans and the condition is increasing at an alarming rate due to overweight and obesity.

People with hyperlipidemia are asymptomatic. Over time, the fat collection in the arteries accompanied by calcium or other substances form plague, leading to narrowing arteries and reduced function of the arteries to transport oxygen-rich blood to parts of the body.

Believe it or not, only half of the people with high blood cholesterol benefits from taking the lowering blood cholesterol medicine.

Cholesterol is a waxy substance produced by the liver. In a moderate amount, it helps to improve the gastrointestinal tract in food digestion, builds strong cell membranes, produces vitamin D and steroid hormones.

The healthy ratio of low-density lipoprotein (LDL)/high-density lipoprotein (HDL) is ant numbers that are less than 4.

In a healthy individual, the bad cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can induce an unhealthy ratio of bad and good cholesterol, leading to bad cholesterol remaining in the bloodstream, a cause of hyperlipidemia.

Overexpression of bad cholesterol has been found to facilitate the plaque accumulated in the arterial wall, a major cause of heart disease and stroke.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding potential and natural foods for the prevention and treatment of high blood cholesterol, researchers investigated the protective effect of Indole-3-Carbinol (I3C) on hyperlipidemia zebrafish larvae and early life stage toxicity of I3C on zebrafish embryos/larvae.

The study included Zebrafish larvae fed with a 4% high-cholesterol diet (HCD) before treatment of I3C 2.5μmol/L and 5μmol/L for two weeks.

According to the results of the tested assays, I3C treated groups showed a decrease of lipid deposition on the vasculature in a dose-dependently, compared to the control group.

I3C inhibited lipid deposition by inducing autophagy was attributed to the enhancement of the networks associated with the regulation of autophagy and apoptosis.

I3C also suppressed the levels of proteins and pathways involved in the regulation of cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription, such as Bcl-2, Akt, p- Akt, mTOR, and p- mTOR.

Based on the findings, researchers said, "I3C shows protective effects on hyperlipidemia zebrafish larvae and maybe a promising multitarget drug in the prevention and protection against atherosclerotic".

Taken altogether, dietary cruciferous vegetables may be considered functional remedies for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indole-3-carbinol inhibits lipid deposition and promotes autophagy in hyperlipidemia zebrafish larvae by Jiang Y1, Yang G1, Liao Q1, Zou Y1, Du Y1, Huang J. (PubMed)

Tocopherols in the prevention of Chronic Epilepsy

By Kyle J. Norton

Epilepsy is a condition of a neurological disorder caused by abnormal electrical activity in the brain inducing sudden recurrent episodes of sensory disturbance and convulsions.

A seizure is a sudden, uncontrolled electrical disturbance in the brain induced the changes to patients' behavior, movements or feelings, and levels of consciousness.

Patients with have two or more seizures or a tendency to have recurrent seizures are considered to have epilepsy.

Believe it or not, seizures have been found associated with a stroke, a closed head injury, an infection such as meningitis or another illness.

However, most cases of seizure have unknown causes.

The most common symptoms of seizure are temporary confusion, uncontrollable jerking movements of the arms and legs, loss of consciousness or awareness and cognitive or emotional symptoms, such as fear, and anxiety.

The seizure has also been found to induce complications such as failing, car accidents due to loss control, pregnancy complications, and emotional health problems such as depression and anxiety.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of symptoms of epilepsy, researchers examined the effect of Tocotrienol activity on seizure-triggered maladaptive neural plasticity and neuroinflammation that occur during the latent period as a key underlying event in epilepsy chronicization.

According to the analysis, α-tocopherol (α-T) reduced hippocampal neuroglial activation and neurodegeneration in the rat model of kainic acid (KA)-induced status epilepticus (SE).

Furthermore, α-T-treated epileptic rats, * showed to increase the number of population spikes elicited by pyramidal neurons, and recovered the latency to the onset of epileptiform-like network activity compared to control levels; (

* Prevented the neuronal death.

* Protected the blood-brain barrier protein by fully reversed the decrease of claudin,

* Inhibited the expression of pro-inflammatory cytokines and exhibited anti-inflammatory cytokines against neuroinflammation.

* Modulated the Genes associated with blood cell development in the hippocampus

Collectively, researchers said, "These findings support the potential of a timely intervention with α-T in the clinical management of SE to reduce epileptogenesis, thus preventing chronic epilepsy development".

Taken altogether, tocopherols may be considered a supplement or improvement of bone collagen formation against the risk of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures by Ambrogini P1, Albertini MC2, Betti M2, Galati C2, Lattanzi D2, Savelli D2, Di Palma M2, Saccomanno S3, Bartolini D4, Torquato P4, Ruffolo G5, Olivieri F6,7, Galli F4, Palma E5, Minelli A2, Cuppini R. (PubMed)

Dandelion (Taraxacum officinale), the Hepatoprotective Functional Herb

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.

Furthermore, the liver produces bile that not only aids the digestive function in food absorption but also builds strong cell membranes, produces vitamin D and steroid hormone.

Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body.

The hepatoprotective effect is the action of the prevention of the liver against liver damage or toxicity.

There is no single cause of liver diseases. Researchers suggested that virus such as hepatitis A, B, C, long-term excessive alcohol drinking and genetic mutation inherited from the parents is the major risk factors associated with the early onset of the diseases.

Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.

Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.

Sadly, the mortality rate infected by viral hepatitis has increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of liver injury, scientists examined the hepatoprotective activity of T. Officinale leaf extract against Acetaminophen (APAP)-induced hepatotoxicity.

According to the tested results, T. officinale decreased the thiobarbituric acid-reactive substance levels and prevent the decrease in sulfhydryl levels induced by 200 mg/kg APAP (p.o.).

Histopathological alterations, and increased levels of liver stress markers such as serum aspartate and alanine aminotransferases caused by APAP, were also inhibited by the application of T. Officinale at the doses of 0.1 and 0.5 mg/mL.

Moreover, T. Officinale extracts also enhanced the antioxidant and scavenger activity against 2,2-diphenyl-1-picrylhydrazyl and nitric oxide radicals.

Collectively, researchers said, "hepatoprotective effect of T. Officinale against the toxicity induced by APAP. The possible mechanisms involved include its scavenger activities against ROS and reactive nitrogen species, which are attributed to the content of phenolic compounds in the extract".

Taken altogether, dandelion may be considered a remedy for the protection of the liver functioning, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antioxidant properties of Taraxacum officinale leaf extract are involved in the protective effect against hepatoxicity induced by acetaminophen in mice by Colle D1, Arantes LP, Gubert P, da Luz SC, Athayde ML, Teixeira Rocha JB, Soares FA. (PubMed)

Herbal Angelica Protects the Liver and Kidney Against Injury Caused by Inflammatory Stress

By Kyle J. Norton

Inflammation is a natural response of the immune system in the stimulation of the production of inflammatory cytokines with an aim to protect our body against infectious agents in the acute phase of bodily injury and tissue damage.

Inflammation cancer classified into
*Acute inflammation is a natural response of the immune system to protect the human body against harmful stimuli and pathogens.

Acute information is the first phase of injection. At this phase, after sensing the body injury by the central nerves system, the immune first line of defense stimulates the production of blood platelets to cover the site of damage and pro-inflammatory to kill off pathogens that try to enter the body through the wound or damaged tissue.

Acute inflammation usually receded after a few days or weeks depending on the size and damage. However, if all pathogens were not eradicated after 3 to 8 weeks, the immune system will compromise, leading to chronic low-grade inflammation, a leading cause of chronic illness.

The most common symptoms of acute inflammation occurred with a short period of time such as hours is pain, redness, immobility, swelling, and heat.

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.

On the other hand, the kidneys are a pair of kidney-shaped organs located on either side of your spine with a function to filter out the wastes from the blood before passing the wastes through urinary secretion.

More than a detoxed organ, the kidneys also maintain the body fluid balance, regulate the production of red blood cells and high blood pressure.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a potential compound for the prevention and treatment of diseases associated with inflammatory injury, researchers examined the effects of Angelica Sinensis on its effects on liver and kidney injury in an animal model.

The study included mice that were subjected to hypodermic injection with D-gal (200 mg/kg) and orally gavaged with AS (20, 40, or 80 mg/kg) once a day for 8 successive weeks.

According to the tested analysis, AS significantly showed a strong improvement in the liver and kidney function, assessed by organ index and functional parameters.

Furthermore, AS pretreatment effectively ameliorated the histological deterioration caused by the injection of D-gal.

Moreover, the application of AS  attenuated the MDA stress marker levels in the kidney and liver by enhancing the activities and gene expressions of antioxidative enzymes produced by the host.

Pro-inflammatory cytokines associated with kidney and liver toxicity caused by the injection of D-gal-mediated such as iNOS, COX-2, IκBα, p-IκBα, and p65 were also attenuated by the AS, accompanied by the promoting of a protein involved in the regulation of proinflammatory expression in both hepatic and renal tissues.

Based on the results, researchers said, "AS pretreatment could effectively guard the liver and kidney of mice against D-gal-induced injury, and the underlying mechanism was deemed to be intimately related to attenuating oxidative response and inflammatory stress".

Taken altogether, herbal Angelica may be considered a remedy, for the protection of the liver and kidney against inflammatory stress. pending to larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Angelica sinensis Supercritical Fluid CO2 Extract Attenuates D-Galactose-Induced Liver and Kidney Impairment in Mice by Suppressing Oxidative Stress and Inflammation by Mo ZZ1,2, Lin ZX2, Su ZR1,3, Zheng L4, Li HL4, Xie JH5, Xian YF2, Yi TG4, Huang SQ6, Chen JP. (PubMed)