Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals

Wednesday, 18 October 2017

Food Therapy: Roasted Coffee in Enhanced Neuroprotective Effects

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Intake of coffee daily may have a strong impact in reduced risk and treatment of neurodegenerative diseases, a renowned institute study suggested

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In rat study to investigate the effect of eicosanoyl-5-hydroxytryptamide(EHT) isolated from coffee against MPTP model of PD with rats fed a diet containing EHT for four weeks exhibited dose-dependent preservation in compared to animals given control feed, researcher found that
1. Mice fed with EHT exhibited a decreased protein aggregation and phosphorylation and improved neuronal integrity and reduced neuroinflammation.
2. The levels of degeneration of dopaminergic neurons(striatal dopamine (DA)) and tyrosine hydroxylase depletion, in the biosynthesis of DA also lower in fed rats in compared to control.
3. Fed rats also displayed a lower indice of oxidative stress and JNK activation in reduced neuro cell apoptosis.

Dr. V, the led author said, " neuroprotective effect of EHT against MPTP(induced PD) is through several mechanisms including its anti-inflammatory and antioxidant activities as well as its ability to modulate the methylation and hence activity of (phosphoprotein phosphatase 2A) PP2A(related to AD development)".

Other study suggested that coffee with its chemical compound cytoprotective transcription factor Nrf2 in activated the expression of antioxidant proteins, is the ingredient in induced neuroprotective in fly PD models as shown in Drosophila models of Alzheimer's disease and polyglutamine disease, through coffee (regardless to caffeinated or decaffeinated)

Dr. Trinh K, the led author said, "coffee......contain Nrf2-activating compounds that may account for the reduced risk of PD among coffee ....users. These compounds represent attractive candidates for therapeutic intervention in PD and perhaps other neurodegenerative diseases".

More importantly, in the study of the effect of different types of coffee against risk neuro degenerative diseases, researchers at the Kraft Foods Research & Nutrition showed that

1. All regular and decaffeinated samples of both roasted and green coffee showed high hydrophilic antioxidant activity in vitro,
2. In neuronal cell cultures, pretreatment with green and roasted coffees (regular and decaffeinated) protected against expression of oxidative stress.
3. Roasted coffee regardless to caffeine content, exerted a much higher protection of cell survival of 203% in compared to 78% of green coffee.
4. Only roasted coffee expressed a significant activity in inhibited neuro cell apoptosis.

Further observation, also indicated that coffee phenolic compounds in roasted coffees demonstrated high levels of chlorogenic acid lactones (CGLs) which has been found to induce neuroprotective efficacy through other studies.

Taking altogether, there is no doubt that roasted coffee intake, regardless caffeineated content, displayed a significant effect in attenuated risk and treatment of neurodegenerative diseases.

Food Therapy: Caffeinated and Decaffeinated Coffee in Lower Risk of Mortality in Chronic illness Patients, excluding Cancers

By Kyle J. Norton

Regular consumption of caffeinated and decaffeinated coffee may prolong total mortality rate on chronic illness patients excluding cancers, a study by renowned institute suggested.

Coffee, becoming a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

The review of literature using the databases of PubMed and EMBASE databases to search all articles published through June 2013, produced twenty studies of coffee consumption and total mortality, including 129,538 cases of deaths among the 973,904 participants met the guidelines, researchers at the Kyung Hee University, filed the following reports
1. The Relative risk ratio(RR) of total mortality for the high v. low category of coffee consumption was 0.86 in compared to .95 of the base line
2. The relative risk ratio was similar to The pool of ≥ 2-4 cups/d and ≥ 5-9 cups/d
3. Coffee consumption showed a strongly inverse association to risk of total motility expression in Japanese and European studies in compared to studies in US.
4, Risk of motility showed no gender difference
5. Both moderated caffeine coffee and decaffeinated coffee expressed an inverse association in lower risk of death.

Regardless to types of chronic illness, coffee displayed a significant value in a reduced risk of total mortality.

Furthermore, in review of associations of consumption of total, caffeinated, and decaffeinated coffee with risk of subsequent total and cause-specific mortality among 74,890 women in the Nurses' Health Study (NHS), 93,054 women in the Nurses' Health Study II, and 40,557 men in the Health Professionals Follow-up Study, after reading the returned semiquantitative food frequency questionnaire, researchers suggested that
1. Consumption of total, caffeinated, and decaffeinated coffee were associated to reduced risk of mortality, nonlinearly.
2. Coffee intake of 1 to 5 cups per day expressed a strong effect in lower risk of mortality in compared to non coffee drinking group
3. Coffee consumption of more than 5 cups per day was associated with reduced risk of mortality.
4. Caffeinated coffee and decaffeinated coffee displayed a similarly significant inverse associations in risk of motility.
5. More importantly, coffee consumption exhibited a enormous effect in reduced deaths attributed to cardiovascular disease, neurologic diseases, and suicide but not in cancer patients.

Dr.Ding M , the lead author said, "when restricting to never smokers compared with nondrinkers, the hazard ratios of mortality were 0.94 for 1.0 or less cup per day, 0.92 for 1.1 to 3.0 cups per day, 0.85 for 3.1 to 5.0 cup per day, and 0.88 for more than 5.0 cup per day".

Interestingly, in this restriction, numbers of cup intake daily were associated linearly to lower risk of total motility in compared to non linearly in other group.

In support to the above differentiation, the Brigham and Women's Hospital study to assess of the association between coffee consumption and mortality from cardiovascular disease (CVD), cancer, and all causes during 18 years of follow-up in men and 24 years of follow-up in women, filed the the following results

1. After adjustment for age, smoking, and other CVD and cancer risk factors, coffee intake showed a moderated effect in lower on all-cause and CVD in both gender but no statistically significantly associated with risk for cancer death

2. Caffeine was not associated to risk of motility

Taking altogether, caffeinated and decaffeinated coffee showed a profound and positive effect in lower risk of motility linearly and nonlinearly in chronic illness other than cancers, depending to other risk factors and group selection.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee consumption and total mortality: a meta-analysis of twenty prospective cohort studies by Je Y1, Giovannucci E2.(PubMed)
(2) Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts by Ding M1, Satija A1, Bhupathiraju SN1, Hu Y1, Sun Q1, Han J1, Lopez-Garcia E1, Willett W1, van Dam RM1, Hu FB2.(PubMed)
(3) The relationship of coffee consumption with mortality by Lopez-Garcia E1, van Dam RM, Li TY, Rodriguez-Artalejo F, Hu FB.(PubMed)

Food Therapy: Dried Pea and Bean Fibers in Reduced Incidence of Hypertension

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Intake of dried pea and bean fibers daily and regularly may reduce risk and treatment of hypertension, a respectable medical service study suggested.

Dried pea is a small but nutritionally mighty member of the legume family, genus Pisum belongings to the family Fabaceae with healthy source of proteins, fibers, vitamins and minerals.

According to the Veterans' Affairs Medical Center, daily intake of fiber has emerged not only to prevent and treat various types of chronic diseases.but also reduced risk of hypertension.

Dr. Anderson JW, the led author said, "Dried beans, oat products, and certain fruits and vegetables are good sources of soluble fiber" and "Current guidelines advise a doubling of dietary fiber intake for Americans. Inclusion of ample servings of fruits and vegetables, whole grains, and dried beans and peas will help individuals meet these guidelines".

Additionally, in the examined iineralocorticoid excess-treated mice with a control diet, high-fiber diet, or acetate supplementation researcher found that high fiber diet not only modified the gut microbiota populations and also increased the abundance of acetate-producing bacteria independently of mineralocorticoid excess and reduced systolic and diastolic blood pressures.

Dr. Marques FZ, the led researcher said, "The favorable effects of fiber may be explained by the generation and distribution of one of the main metabolites of the gut microbiota, the short-chain fatty acid acetate. Acetate effected several molecular changes associated with improved cardiovascular health and function."

These result demonstrated a significant effect of fibers intake in promoted health gut microbiota in regulating molecular changes associated with improved risk factor related to cardiovascular health and function, including blood pressure.

Other, in the examined cross-sectional studies of dietary intake as one of the major determinants in hypertension development and Dietary Approach to Stop Hypertension and the risk of incident hypertension in a large cohort study including incidence of hypertension among 80 426 French adults, researchers at the joint study led by the Paris-Descartes University found that
1. During a mean follow-up of 3.4±2.1 years, 2413 cases of incident hypertension were documented
2. Fiber intake displayed a strong effect in reduced risk of hypertension with relative odd risk of 0.81 in compared to the baseline.
3. Adopting a global healthy diet associated to several nutritional factors intake may be one of the best solution in reduced hypertensive incidence

Taking altogether, dried peas and beans fibers accompanied with adequate intake of marco nutrients and reduced intake red and processed meat may form a daily diet in reduced risk of hypertension

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Health benefits and practical aspects of high-fiber diets by Anderson JW1, Smith BM, Gustafson NJ.(PubMed)
(2) High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice by Marques FZ1, Nelson E2, Chu PY2, Horlock D2, Fiedler A2, Ziemann M2, Tan JK2, Kuruppu S2, Rajapakse NW2, El-Osta A2, Mackay CR2, Kaye DM1(PubMed)

(3) Individual and Combined Effects of Dietary Factors on Risk of Incident Hypertension: Prospective Analysis From the NutriNet-Santé Cohort by Lelong H1, Blacher J2, Baudry J1, Adriouch S1, Galan P1, Fezeu L1, Hercberg S1, Kesse-Guyot E1.(PubMed)

Food Therapy: Black Bean, Reduced Risk and Treatment of Colitis

Kyle J. Norton

People who turn to alternative medicine for treatment of disease in avoidance of adverse effects induced by conventional medicine should be patient. In compared to herbal medicine; food therapy even takes longer than six months to ease symptoms, depending to stages of the treatment which directly address to the cause of disease.

Black bean with abundant chemical constituents and fiber may be considered as function foods for prevention and treatment of colitis, a renowned institute indicated.

Colitis is medical condition of inflammation of the inner lining of the colon.

Black bean, a small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the joint study lead by the University of Guelph, in vivo, cooked whole-bean flours, with differing phenolic compound levels and profiles, showed a completed inhibition of colitis in a mouse model.

In C57BL/6 mice fed a 20 % navy bean or black bean flour-containing diet or an isoenergetic basal diet (BD) for 2 weeks before the induction of experimental colitis via 7 d dextran sodium sulphate (DSS, 2 % (w/v) in the drinking-water) exposure, coincidentally, both groups exerted similarly a beneficial and adverse effects in induced locally and systemically while aggravating colonic mucosal damage with unknown identity and systemic inflammation.

In bean treatment group, the efficacy in ameliorated colitis may be a result of the inhibition of pro inflammatory expression, such as colonic inflammatory cytokines (IL-6, IL-9, IFN-γ and IL-17A) and increased anti-inflammatory IL-10.

In mice with colon inflammation triggered by high-fat diet (HD)-induced obesity, injection of black bean expressed a significant decreased the concentrations of lipid and various circulating proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in mice with HD-induced obesity, in attenuated change associated to colon inflammation.

Furthermore, mice treated with black bean also improved antioxidant status in reduced progression
of reactive oxygen species (ROS) in induction of oxidative stress.

Dr. Yook JS, the lead researchers said, "BAB ameliorates HD-induced disorders such as obesity and colitis by improving mucosal barrier protection and reducing endotoxemia, as well as by inactivating NF-κB to decrease the production of proinflammatory cytokines".

Taken together, black bean may be considered as a functional diet in reduced risk of colitis in high risk healthy subjects and treatment of patients with colitis with little or no adverse effects.

Sources
(1) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA1.(PubMed)

Tuesday, 17 October 2017

Food Therapy: Coffee and Coffee Caffeine In Reduced Risk Of Thyroid Cancer?

Epidemiological studies, linking coffee and coffee caffeine intake in prevalence of thyroid cancer incidence have been contradictory and inconclusive.

Thyroid cancer is a chronic condition of irregular cell growth in the thyroid gland.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

In the review of database from Published studies in PubMed, Embase, Cochrane Central, and the reference lists of the retrieved articles to evaluate the association between coffee consumption and the risk of thyroid cancer, researchers at the joint study lead by the Chosun University, filed the following results.
1. In a total of 1039 thyroid cancer cases and 220,816 controls were identified from five case-control studies and two cohort studies, the relative risk ratio of cancer incidence was was 0.88 in compared to base line.
2. Risk of thyroid cancer was reduced significantly only in hospital-based case-control studies.

Dr. Han MA, the head researcher said, "There was no significant association between coffee consumption and thyroid cancer risk according to our meta-analysis results" and "There was no significant heterogeneity among the study results".

Other, in the analyzed data from a prospective cohort (100,507 persons (48,802 men; 51,705 women) aged 40-69) between green tea and coffee consumption and risk of thyroid cancer, assessed via a self-administered questionnaire, researchers at the National Cancer Center found no association between coffee intake and risk of thyroid cancer regardless to gender and amount of coffee intake per day.

Furthermore, in the pool sample consisted of 2725 thyroid cancer cases (2247 females, 478 males) and 4776 controls (3699 females, 1077 males), through intensive analysis of 14 case-control studies conducted in the United States, Europe, and Asia suggested that risk of thyroid cancer is not associated to coffee consumption, independent to gender difference.

The study also emphasized that even taking into account of other factors, caffeinated beverages did not alter thyroid cancer risk.

Contrastively, according to Aretaieion University Hospital, in a case-control, serially matched study containing 70 patients with thyroid cancer, 55 with benign thyroid disease and 71 controls, there were significantly reduced risk of thyroid disease among coffee and coffee caffeine drinkers. Even after adjustment for possible confounding variables, the association remained statistically significant

Dr. Linos A, the lead author said, " The mechanism by which coffee consumption may play a protective role against development of benign or malignant thyroid neoplasms may be the stimulatory effect of caffeine on the intracellular cyclic AMP production, which is known to inhibit cell growth".

Taking altogether, the contradict results may warrant a large sample size and cohost studies before researchers can make a decision between coffee and coffee caffeine intake and risk of thyroid cancer.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis by Han MA1, Kim JH2.(PubMed)
(2) Green tea and coffee consumption and its association with thyroid cancer risk: a population-based cohort study in Japan by Michikawa T1, Inoue M, Shimazu T, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S.(PubMed)
(3) A pooled analysis of case-control studies of thyroid cancer: cigarette smoking and consumption of alcohol, coffee, and tea by Mack WJ1, Preston-Martin S, Dal Maso L, Galanti R, Xiang M, Franceschi S, Hallquist A, Jin F, Kolonel L, La Vecchia C, Levi F, Linos A, Lund E, McTiernan A, Mabuchi K, Negri E, Wingren G, Ron E.(PubMed)
(4) Does coffee consumption protect against thyroid disease? by Linos A1, Linos DA, Vgotza N, Souvatzoglou A, Koutras DA.(PubMed)

Food therapy: Coffee in Reduced risk of Respiratory Diseases?

By Kyle J. Norton

Intake of coffee and coffee caffeine may have a potential effect in reduced risk and progression of respiratory disease, a renowned university study suggested.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Respiratory disease is a class of diseases involved abnormal lung function including conditions of the upper trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity,....

In review of 15 studies, including seven cohorts, six cross-sectionals, one case control and one randomized control trial, researchers at the joint study lead by the University of Coimbra, filed the below interesting results1. Risk of asthma was reduced in coffee injection group.
2. Coffee accompanied with honey displayed a positive effect in treatment for persistent post-infectious cough.
3. In control study, the higher risk of chronic obstructive pulmonary disease(COPD) prevalence was associated to coffee consumption.4. Coffee was also found to associate to lower respiratory mortality.
5. Coffee injection group also benefit to improved lung function
6. Smoking was a significant risk factor in all cases.

With all the information collected, Dr. Alfaro TM, the lead authors proposed, "Coffee consumption was associated with some positive effects on the respiratory system" and "coffee consumption may be a part of a healthy lifestyle leading to reduced respiratory morbidity."

Other, in the study filed by the CHU de Nancy, coffee consumption showed a contradictory effect involving respiratory diseases.
1. Coffee intake showed a beneficial effect on bronchospasm.
2. But on other studies, coffee intake has been suspected of contributing to the development of chronic airflow obstruction (COPD) and bronchial cancer.

The study explained, these contrastive results may be attributed to the causal relationship in indirectly linking strong positive correlation between the consumption of coffee and use of tobacco.

The author also warmed that coffee taken in large quantities by pregnant women, may increase risk of neonatal apnoea in the newborn, if abrupt cessation in the caffeine level.

Also in the comparison of the prenatal exposure to acetaminophen and coffee with childhood asthma, researchers found that intake of coffee during pregnancy showed a strong effect in reduced risk of childhood asthma, according to the 63,652 live-born singletons enrolled in the Danish National Birth Cohort.

Taking together, coffee intake have a strong protection against respiratory diseases(including reduced risk of childhood asthma), but increased incidences of chronic airflow obstruction (COPD), and bronchial cancer, therefore, people with above exceptive disease should reduced intake of coffee and consult with their doctors.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Chronic coffee consumption and respiratory disease: A systematic review by Alfaro TM1,2,3, Monteiro RA1, Cunha RA2, Cordeiro CR1,3.(PubMed)
(2) [Effects of coffee on the respiratory system].[Article in French] by Martinet Y1, Debry G.(PubMed)
(3) Association of prenatal exposure to acetaminophen and coffee with childhood asthma by Liu X1, Liew Z2, Olsen J1,2, Pedersen LH3, Bech BH1, Agerbo E4,5, Yuan W6, Li J7.(PubMed)

Food therapy: Coffee Caffeine In Risk of Systemic Lupus Erythematosus in Women with Mutation of Gene NAT2

Kyle J. Norton

Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of various diseases, but single ingredient isolated from such plants may induce opposite responses.

Intake of coffee caffeine daily has induced conflicted results in risk of auto immune disease, systemic lupus erythematosus epidemiological studies suggested.

In the assessment of 152 SLE cases and 427 healthy controls, in Japanese women in testing the interaction of NAT2 polymorphism, acting primarily in the liver to detoxify a large number of chemicals including caffeine and consumption of beverages, researchers found that coffee with a relative risk of 1.57 showed a significant increased risk of SLE,

Mutation of gene NAT2, involved in the metabolism of several compounds relevant in pharmacology or toxicology showed a direct effect in significantly modified alcohol use and black tea consumption on SLE, but not in coffee.

These findings suggested that certain beverages may have an implication in elevated gene change in risk of systemic lupus erythematosus, such as alcohol in reduced but black tea in increased risk of systemic lupus erythematosus.

Other, in the evaluated possibility of environmental lupus erythematosus provocative substances eliminated by acetylation in 36 Chinese women with mild, stable, and confirmed lupus erythematosus and 36 healthy control subjects matched for age, sex, and ethnic origin, researchers at the University of Hong Kong. found that 1 - 4 hours after drinking a strong cup of coffee (caffeine), there was no association between slow acetylator status and lupus erythematosus in the both study subjects.

Acetylator is found to associated to a relatively high incidence of systemic lupus erythematosus.

Taking altogether, there is no doubt that coffee caffeine only has a direct effect in increased risk of systemic lupus erythematosus in women with mutation gene NAT, but not other environmental provocative substances. Further cohost and large sample size are necessary to reassess these implications.

Author Biography

Sources
(1) Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages by Kiyohara C1, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y; Kyushu Sapporo SLE (KYSS) Study Group(PubMed)
(2) Coffee and autoimmunity: More than a mere hot beverage!by Sharif K1, Watad A1, Bragazzi NL2, Adawi M3, Amital H1, Shoenfeld Y4.(PubMed)
(3) Lack of association between slow acetylator status and spontaneous lupus erythematosus by Kumana CR1, Chan MM, Wong KL, Wong RW, Kou M, Lauder IJ.(PubMed)