By Kyle J. Norton
Beet, one of the root vegetables may have a therapeutic effect in reduced risk and treatment of breast cancer, a renowned institute opinionated.
Beet, a perennial plant with leafy stems growing to 1–2 m tall, is best known as the beetroot or garden beet, belongings to the amaranth family
According to Howard University, an extract of red beetroot (Beta vulgaris L.), the FDA-approved red food color E162, in an animal model, exhibited anti-cancer activity by suppressing the early onset of multi-organ tumors.
In the comparison of the red beetroot extract and anticancer drug, doxorubicin cytotoxic effect against estrogen receptor-positive human breast cancer cells (MCF-7), both treated groups exerted a similar and significant anti-breast cancer cell line effect in the induction of cytotoxicity. However, the cytotoxicity of the beetroot extract was significantly lower than those of doxorubicin.
Dr. Kapadia GJ, the lead author postulated, the breast cancer cell line inhibition of beetroot may be attributed to the phytochemical betanin, the principal betacyanin constituent found abundantly in the vegetable.
Also in the testing of the chemotherapeutic drug doxorubicin (DOX, Adriamycin), at different concentrations of BRJ (0.5, 5, 50, 250, and 500 µg/ml) with or without DOX, BRJ showed a significantly reduced breast cancer cell growth within and at 48 hours, similar to those of DOX-induced apoptosis, observed by TUNEL assay.
Additionally, in dose-dependent, co-treatment of BRJ and DOX improved the efficacy of treatment in enhanced apoptosis in breast cancer cells by exerting a strong effect in the ameliorated generation of reactive oxygen species (ROS) produced by DOX.
In fact, lower concentrations, a combination of BRJ and DOX, also displayed the most effectiveness in explicit cardioprotection and chemoprevention in tested subjects synergistically.
More importantly, Dr. Kapadia GJ, the lead author in the other study conducted by the same University said, "Long-term daily exposure to low doses of B through diet might be safe and sufficient to produce cancer chemopreventive effect in humans.
Promisingly, the intake of beet juice may also contribute to an overall positive reduction in DOX drug concentration in use to influence cytotoxicity activity for the treatment of human breast cancer.
Taken together, Beet Juice, used alone or combined with chemotherapeutic medicine, maybe a functional food for reduced risk and enhanced breast cancer treatment.
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Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer-cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H.(PubMed)
(2) Beetroot juice protects against doxorubicin toxicity in cardiomyocytes while enhancing apoptosis in breast cancer cells by Das S1,2, Filippone SM1, Williams DS3, Das A1, Kukreja RC4,5. (PubMed)
(3) Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines by Kapadia GJ1, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H.(PubMed)
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