Tuesday, 27 June 2023

#ChineseCelery Exerts a Neuroprotective Effect Against Some Complications After #Stroke, Researchers Show

Kyle J. Norton

Scientists may have found a whole food for the treatment and improvement of the quality of life of post-stroke patients without inducing any side effects, according to studies.

Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.

In other words, a stroke can either be the result of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain inducing permanent damage.

Depending on the parts of the neuron being damaged, patients may experience different symptoms. However, the most common symptoms of stroke include paralysis or numbness of the face, arm, or leg, problems in vision, speaking, walking, and persistent headache.

Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, and ethnicity are some prevalent risk factors for stroke.

Out of many risk factors, people who have hypertension, particularly untreated hypertension, and follow the Western diet are at increased risk of the onset of stroke, according to epidemiological studies.


In examining the post-stroke patients, a poor diet pattern with a high of saturated and trans fat, red meat, and processed foods has been found in the high percentage, compared to the traditional diet.

Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in risk of stroke wrote, "Adherence to the improvements in nutrition and diet can reduce the incidence of stroke. Higher antioxidant, vitamins, potassium, calcium, vegetables, fruits, whole grain intake, and adherence to the Mediterranean diet or DASH diet can lower stroke incidence".

The statement clearly suggested that a healthy diet rich in fruits and vegetables and whole grains and low in red meat, saturated fat and trans fat, and processed food is the best for prevention and stroke.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. The plant is cultivated all around the globe as a vegetable.

Celery can grow to 1/2 m tall with stalks (leaf on the top) arranged in a conical shape joined at a common base.

On finding a natural ingredient with no side effects for the treatment of patients with acute ischemic stroke, researchers evaluated the Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, efficacy in animal models of stroke.

The randomized, double-blind, double-dummy trial included 573 patients within 48 hours of onset of ischemic stroke in China.

Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14-day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin.


After taking into account co and confounder, among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP demonstrated a significant improvement over 14-day treatment with ozagrel as measured by the modified Rankin scale (mRS).

Where Ozagrel (INN) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.

According to the Barthel index at day 90, there is no significant difference among the three groups. The rate of adverse events was similar among the three groups.

Furthermore, a stroke inExertnti-oxidant agent prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging, and histological assessment by Zhang L1, Yu WH, Wang YX, Wang C, Zhao F, Qi W, Chan WM, Huang Y, Wai MS, Dong J, Yew DT. (PubMed)
(3) Stroke and Nutrition: A Review of Studies by Mehdi Foroughi,2 Mohsen Akhavanzanjani,2 Zahra Maghsoudi,2 Reza Ghiasvand,1,2Fariborz Khorvash,3 and Gholamreza Askari. (PMC)

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