By Kyle J. Norton
Bilberry may be the next potential therapeutic treatment for breast cancer with no side effects, according to studies.
Breast cancer is a chronic condition characterized by irregular cell growth in the breast tissue caused by the alternation of DNA.
The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, some are susceptible to the onset of breast cancer while others do not.
According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.
Believe it or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.
The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breasts at least once a month for preventive measures.
Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, and scaliness.
If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.
In North America, some researchers suggested that obesity may have a strong impact on the risk of breast cancer onset.
Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.
Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.
At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.
In other words, bilberry extract-induced cancer cell apoptosis was not through cell cycle arrest at this concentration.
However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.
Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).
Moreover, researchers found that the efficacy of bilberry against breast cancer cells was attributed not to the expression of anthocyanins but to all phytochemicals in the extracts.
Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.
And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".
Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending the confirmation of a larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)
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