Tuesday, 17 August 2021

Beta-Sitosterol in the Promotion of Immunomodulatory Activity

By Kyle J. Norton

The immune system is the set of cells associated with the activity against antigens or infectious agents.
It is one of the body's defense system against diseases.

The immune system does a great job of keeping people healthy and preventing infections.

Besides foods and nutritional supplements, herbs also play important roles in helping the immune system to defend against viruses and bacteria attacks.

A variety of factors have been found to trigger immune responses include pathogens, damaged cells, and toxic compounds.

Immune dysfunction is a chronic condition, depending on the parts of the immune system affected.

There are 2 types of immune dysfunction. The underactive immune system is also known as weakened immune system People with the underactive immune system are susceptible to infection, recurrent infections, autoimmune disorders, damage to heart, lungs, nervous system or digestive tract, increased risk of cancer, malnutrition, and death from a serious infection.

Immunomodulation is a process in which an immune response is altered to the desired level. In other words, under the immunomodulatory effect, the immune system is responding correctly to the desire of the body, regardless of types of immune dysfunction.

More precisely, immunomodulation is an action with a profound and positive effect in regulated immune response and function through activation of antibody formation or the inhibition of white blood cell activity.

Beta-Sitosterol is a phytochemical in the class of Phytosterols, belongings to the group of Lipids, found abundantly in avocados, rice bran, wheat germ, corn oils, fennel, peanuts, soybeans, hawthorn, basil, buckwheat. etc.

On finding a potential phytochemical for the improvement of the immune functioning, researchers examined the immunomodulatory effects of Beta-sitosterol (BSS) on the pig immune system using in vitro cell cultures and in vivo activity in fattener pigs after vaccination with porcine reproductive and respiratory syndrome virus (PRRSV) modified life vaccine (MLV).

According to the chemical analysis,
* In vitro, BSS increased viable peripheral blood mononuclear cell (PBMC) numbers that act as an immune response to pathogens and activated swine dendritic cells (DCs) that act as messengers between the innate and the adaptive immune systems.in culture. 

* In vivo, pigs treated with phytosterols prior to vaccination with PRRSV-MLV vaccine exhibited some changes in immunological parameters at different times post-vaccination, such as the proliferation ability of PBMC as well as increasing the apolipoprotein A1 plasma concentration which may contribute to enhance PRRSV vaccine response.

Based on the findings, researchers said, " In conclusion, the data in this report show that BSS can be considered an immunomodulator in pigs".

Taken altogether, beta-Sitosterol may be considered a supplement for the improvement of immunomodulatory activity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory properties of beta-sitosterol in pig immune responses by Fraile L1, Crisci E, Córdoba L, Navarro MA, Osada J, Montoya M. (PubMed)

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