Tuesday, 28 September 2021

Lycopene Inhibits Metabolic Diseases in Obese

By Kyle J. Norton

A metabolic profile is a tool to diagnose metabolic disease.

A metabolic disease is a group of medical conditions that disrupt normal cell metabolism in converting food to energy.

The most common causes of metabolic disease are genetic prepositions. However, people with the mutated gene may remain healthy for years.

Interestingly, cellular stress and family history have been found to be major causes of the initiation of the symptoms of metabolic disease, epidemiologically.

According to statistics, metabolic disease is uncommon in the US. Metabolic disorders affect approximately 1 in 1,000 individuals.

As of today, there is no effective treatment of metabolic disease. Some children with metabolic disease diagnosed at an early age may respond very well to therapy. However, many do not respond well to therapy and cause severe problems, despite the early diagnosis.

Obesity is a medical and chronic condition caused by long-term excessive body fat accumulated. Overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), people who have a BMI between 25 to 29.9 are considered overweight and a BMI of over 30 is an indication of obesity.

The formula of the BMI indexBMI= weight (kg)/ height (m2)

According to the statistic, 68% of the American population is either overweight or obese. However,
in 2016, more than 1.9 billion adults, 18 years and older, were overweight, including over 650 million were obese worldwide.

Lycopene is a phytochemical found in tomatoes in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potential compound for the treatment of metabolic disease, researchers compared the effect of lycopene and tomato powder on obesity-associated disorders in an animal model.

Male C57BL/J6 mice selected to the study were assigned into four groups to receive: control diet (CD), high-fat diet (HFD), a high-fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks.

In HFD experimental mice, lycopene and TP supplementation significantly reduced adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids, 8-iso-prostaglandin GF2α, and improved glucose homeostasis, without affecting the total body weight. 

Furthermore, lycopene and TP supplementation protected the liver cell against HFD-induced hepatosteatosis and hypertrophy of adipose tissues.

Moreover, levels of pro-inflammatory cytokines induced by HFD also were reduced observed by the decreased mRNA expression in the liver and in the epididymal adipose tissue.

Additionally, levels of phosphorylation of IκB, and p65 associated pro-inflammatory responses were also decreased through the applications' anti-inflammatory activity.

Collectively, researchers said, "These results suggest that lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies".

Taken altogether, lycopene and tomato may be considered remedies for the prevention and treatment of metabolic diseases, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders by Fenni S1,2, Hammou H2, Astier J1, Bonnet L1, Karkeni E1, Couturier C1, Tourniaire F1, Landrier JF. (PubMed)

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