Healthy Food Onion Processes Anti Asthmatic Activity

By Kyle J. Norton

Respiratory disease is a class of medical conditions that affect the breathing organ and tissues. Most common respiratory diseases are inflammatory lung disease, obstructive lung diseases, restrictive lung diseases, and respiratory tract infections.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. 

The medical condition affects people of all ages, and mostly starts during childhood. 

In the US, approximately,  25 million people are living with asthma, including 7 million children.

Most common risk factors associated with the onset of asthma, according to epidemiological studies are

* Wheezing rhinovirus illnesses
Virus-induced wheezing episodes in infancy often precede the development of asthma. 

*Airflow obstruction
Asthma and family history of allergic rhinitis are important risk factors associated with airflow. according to the Department of Pediatrics, Lerdsin General Hospitalobstruction.

* Gender
If you are women, you are at increased risk to develop asthma. Asthma, after childhood, is more severe in females than in males and is under-diagnosed and under-treated in female adolescents.

*  Stress
Stress, whether at the individual (i.e. epigenetics, perceived stress), family (i.e. prenatal maternal stress, early-life exposure, or intimate partner violence) or community (i.e. neighborhood violence; neighborhood disadvantage) level, influence asthma and asthma morbidity.

* Genes
GSTP1, INSIG2, and IL4Ra may influence the lifetime asthma susceptibility through gene-gene interactions in schoolchildren. 

* Airway inflammation and hyperreactivity
People with airway hyperreactivity are at increased risk to develop asthma as a result of the immune system over response to allergens. 

5. Atopy and viral infection
Atopy – such as eczema, allergic rhinitis, allergic conjunctivitis, and viral infection are associated with a higher risk of asthma development. 

* Family history
Family history of asthma in one or more first-degree relatives was consistently identified as a risk factor for asthma. 

* Smoke during Pregnancy
Smoking and severe asthma exacerbations in pregnancy are risk factors for low birth weight babies.
During pregnancy, asthma exacerbations are more common and more severe in current smokers than never smokers. The risk of the effects of maternal asthma on the fetus may be greater among smokers.

* Low birth weight
In the 1988 national birth cohort, an estimated 4000 excess asthma cases were attributable to birth weight less than 2500 g.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of asthma researchers investigated the effect of Allium cepa L. extract (AcE) and its quercetin (Qt) on cytokine and on smooth muscle contraction associated with asthma in vitro and vivo.

According to the tested analysis, 

* In vitro, AcE 10, 100 or 1000 μg/ml or Qt 35, 7.5, 15 μg/ml, showed a significant effect in inhibition of the production of pro-inflammatory cytokines.

* With the same concentrations, AcE also expressed the ability to relax tracheal smooth muscle from A/J mice. 

* Futhermore, with the concentrations of 100, 1000 mg/kg or 30 mg/kg Qt in Blomia tropicalis (BT)-sensitized A/J mice treated, AcE also decreased the total number of cells of bronchoalveolar lavage (BAL), and eosinophil peroxidase (EPO) in lungs, the markers found in patients with asthma.

Based on the results, researchers wrote, "AcE and Qt have potential as antiasthmatic drugs, as they possess both immunomodulatory and bronchodilatory properties".

Taken altogether, onion may be considered a remedy for the prevention and treatment of asthma, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential therapeutic effect of Allium cepa L. and quercetin in a murine model of Blomia tropicalis induced asthma by Oliveira TT1, Campos KM2, Cerqueira-Lima AT3, Cana Brasil Carneiro T4, da Silva Velozo E5, Ribeiro Melo IC6, Figueiredo EA7, de Jesus Oliveira E8, de Vasconcelos DF9, Pontes-de-Carvalho LC10, Alcântara-Neves NM11, Figueiredo CA. (PubMed)
(2) Onions, myths, beliefs, fashion and reality in asthma by Martínez-Gimeno A. (PubMed)
(3)
Asthma (Respiratory Disease) – The Risk factors by Kyle J. Norton