Saturday, 7 July 2018

A Beverage, That Suppresses the Incidence of Rheumatoid Arthritis (RA)

Kyle J. Norton, Master of Nutrition

Total caffeinated coffee intake daily is associated to non risk factor but attenuated risk of incidence of rheumatoid arthritis, the joint study by the Harvard Medical School and Brigham and Women's Hospital, Boston and a Asian study, suggested, respectively.

Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

Rheumatoid Arthritis is a chronic immune disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues in the body.

In other words, the synovial membrane that protects and lubricates joints are inflamed, causing pain and swelling. But what trigger these attacks are still debatable.

The disease affects more women than men and generally occurs after the ages of 40, causing diminished physical activity and quality of life of many people.

According to statistic, 1% of the global population are affected by the disease. In the US, based on rates of RA from a 1995 Minnesota study and 2005 Census data, the prevalent risk  is lower with  approximately 1.29 million or 0.6% of the population.

Some researchers suggested that  Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation(4). 

According to a cross-sectional population-based study of 1042 patients with rheumatoid arthritis, researchers showed that RA patients had an increased risk of death from various causes(5).

The joint study conducted lead by the University of Texas Southwestern Medical Center and Victoria Hospital, the misdiagnosis of the atypical infections versus inflammatory conditions of the hand due to some similarity to inflammatory conditions regarding their clinical and imaging finding is rare but delay diagnosis can increase risk of severe bone and joint destruction, and higher morbidity(6).

Truly, some reseachers believed that habitual coffee consumption are associated to risk of RA. 

Women who have never drunk coffee before showed an increased risk of RA if daily intake of decaffeinated coffee is over 4 cups.

Dr. Mikuls TR, the lead author said, "Decaffeinated coffee intake is independently and positively associated with RA onset" and "Further investigations of decaffeinated coffee and tea intake as arthritis risk factors are needed to verify these findings and explore their biologic basis".

However, according to the study of Korea University Anam Hospital, caffeinated or decaffeinated coffee consumption are not risk factors of RA.

In the follow up study of 83,124 women, completed the FFQ at baseline, the diagnosis of incident RA(between 1980 and 2000) with a food frequency questionnaire (FFQ) completed every 4 years, from baseline in 1980 through 1998, researchers found that
* Decaffeinated coffee consumption of >/=4 cups/day (compared with no decaffeinated coffee consumption) showed no subsequent risk of incident RA.

* There was no relationship of incidence of RA or reduced incidence RA in caffeinated coffee consumption, regardless to numbers of cup intake daily.

* Total coffee and total caffeine consumption were also not associated with the risk of RA.

And coffee intake showed a statistically clinical value in attenuated risk of RA.

According to the Korea University College of Medicine, the numbers of coffee intake daily in reduced RA incidence were substantially different in number studies.

The highest category of coffee intake in Heliovaara et al. cohort study from Finland was up to 13 cups per day, while US studies was > 4 cups coffee intake per day.

The study also emphasized that caffeine showed no significant association of RA incidence in compared to caffeinated coffee consumption in ameliorated risk RA incidence.

Furthermore, the study in valuated coffee, tea, and caffeine consumption and risk factors for rheumatoid arthritis (RA) onset among older women, indicated that risk of RA is reduced substantially with drinking > 3 cups/day of decaffeinated coffee in compared to non drinkers.

Interestingly, women who have never drunk coffee before showed an increased risk of RA if daily intake of decaffeinated coffee is over 4 cups.

Collectively, the finding evidences suggested that caffeinated coffee intake is not an independent risk factor but a reduced risk parameters for onset of rheumatoid arthritis (RA) incidence, depending to numbers of cup consumption per day.

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Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Coffee or tea consumption and the risk of rheumatoid arthritis: a meta-analysis by Lee YH1, Bae SC, Song GG.(PubMed)
(2) Coffee, tea, and caffeine consumption and risk of rheumatoid arthritis: results from the Iowa Women's Health Study by Mikuls TR1, Cerhan JR, Criswell LA, Merlino L, Mudano AS, Burma M, Folsom AR, Saag KG.(PubMed)
(3) Coffee consumption and risk of rheumatoid arthritis by Karlson EW1, Mandl LA, Aweh GN, Grodstein F.(PubMed)
(4) Serum Sclerostin Level Among Egyptian Rheumatoid Arthritis Patients: Relation to Disease Activity ,Bone Mineral Density and Radiological Grading by Mehaney DA, Eissa M, Anwar S, El-Din SF(PubMed)
(5) Death rates and causes of death in patients with rheumatoid arthritis: a population-based study by Sihvonen S1, Korpela M, Laippala P, Mustonen J, Pasternack A(PubMed)
(6) Atypical Infections versus Inflammatory Conditions of the Hand: The Role of Imaging in Diagnosis by Soldatos T1, Omar H, Sammer D, Chhabra A.(PubMed)

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