Intake of nitrate-rich beetroot juice may have a substantial and profound effect in improved vascular function, thus reducing risk of heart disease.
Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family.
Vascular function are bundle vascular system with function in blood circulation.
Abnormal vascular function is considered as one of the risk factor in development of heart disease.
In a total of 69 subjects recruited in this randomized, double-blind, placebo-controlled parallel study to examine the change in vascular function induced by intake of Nitrate-Rich Beetroot Juice, determined with the use of ultrasound flow-mediated dilatation (FMD).
The flow-mediated dilation (FMD).test, an ultrasound technique performed only by a skilled sonographer is a noninvasive assessment of vascular endothelial function through experts understanding of the physiology, analysis, and interpretation of this measurement
Intake of nitrate-rich beetroot juice displayed a significant increase in the FMD response of 1.1% in compared to placebo group of decrease of 0.3%
Nitrate-rich beetroot juice group also demonstrated a small improvement of stiffness measured by Aortic Pulse Wave Velocity and showed a trend of continuous improvement in compared to placebo.
Aortic Pulse Wave Velocity is a test to measure stiffness of the largest artery in the body, Increased stiffness will result in reduced mobility in related regions.
Result of aortic pulse wave velocity measurement is said to have an ability to identify people in their 20’s who are at increased risk for development of heart disease, stroke and dementia.
Administration of nitrate-rich beetroot juice showed a strong reduction of 7.6% of platelet-monocyte aggregates in compared to increase of 10.1% in placebo. This finding indicated that nitrate-rich beetroot juice intake had a substantial effect in decreased risk of acute myocardial infarction.
Platelet–monocyte aggregates is a novel index with platelet activation and a maker of early onset of acute myocardial infarction.
Furthermore, intake of nitrate-rich beetroot juice group expressed an exceptional improvement of vascular function in reduced P-selectin expression in activated platelet aggression
P-selectin is a cell adhesion molecule (CAM) with function in mediated the interaction of activated endothelial cells or platelets.
Additionally, application of the juice also improved the nonpathogenic, commensal bacteria present in the healthy human salivary glands measured by salivary microbiome in compared to placebo group.
Interestingly, intake of the nitrate-rich beetroot juice also responded to change of 78 bacterial taxa out of thousands harbored in human gut.
The proportions of Rothia mucilaginosa trending to increase in nitrate-rich beetroot juice group, in compared to Neisseria flavescens (P < 0.01) increased in the placebo group.
Rothia mucilaginosa, is considered part of the normal microflora of the human mouth and the upper respiratory tract.
Neisseria flavescens is an uncommon pathogen of human infection, pneumonia and empyema
There were no adverse effects of dietary nitrate were detected through out the experiment.
The finding evidences suggested that intake of nitrate-rich beetroot juice daily may have a sustainable effect in improve vascular function, thus reducing risk of heart disease.
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Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study by Velmurugan S1, Gan JM1, Rathod KS1, Khambata RS1, Ghosh SM1, Hartley A1, Van Eijl S1, Sagi-Kiss V2, Chowdhury TA3, Curtis M4, Kuhnle GG2, Wade WG5, Ahluwalia A6(PubMed)